{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:05:17Z","timestamp":1791234317584,"version":"4.1.0"},"reference-count":19,"publisher":"Bioscientifica","issue":"3","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["ec.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,3,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The extent of symptoms due to primary hyperparathyroidism (PHPT) depends on the population being studied. PHPT is mainly discovered incidentally through routine laboratory findings. Less is known about patient-experienced improvement following successful parathyroidectomy. The aim of our study was to assess the changes in the quality of life (QoL) after successful surgery using an SF-36 questionnaire.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>This is a prospective cohort study based on questionnaires.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Forty consecutive patients diagnosed with PHPT were prospectively administered an SF-36 questionnaire before and 6 months after successful parathyroidectomy. A subgroup of 18 patients answered the questionnaire at 1 and 3 months after surgery. Successful surgery was based on biochemistry and pathology reports as confirmed by an endocrinologist. Results of each SF-36 subcategory were compared to the results at baseline in order to detect changes in patient-reported QoL after successful surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There were significant improvements in six of eight SF-36 subcategories: vitality (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.0001), physical functioning (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.04), general health perception (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.004), physical role functioning (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.04), social role functioning (P\u2009=\u20090.004), and mental health perception (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.0001). Changes appeared within a month after surgery with no further significant changes at later time points.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Parathyroidectomy significantly improves QoL as measured by a decrease in SF-36 scores as early as 1 month after successful parathyroidectomy. The SF-36 QoL questionnaire is suitable for monitoring changes in patient well-being after successful parathyroidectomy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1530\/ec-21-0630","type":"journal-article","created":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T12:02:26Z","timestamp":1645617746000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-10","source":"Crossref","is-referenced-by-count":8,"title":["Changes in quality of life 6 months after parathyroidectomy for primary hyperparathyroidism"],"prefix":"10.1530","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2680-0121","authenticated-orcid":true,"given":"Julie Wulf","family":"Christensen","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine, Herlev and Gentofte Hospital, Herlev, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin Folmer","family":"Th\u00f8gersen","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Herlev and Gentofte Hospital, Herlev, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars Thorbj\u00f8rn","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Herlev and Gentofte Hospital, Herlev, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Krakauer","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Herlev and Gentofte Hospital, Herlev, Denmark"},{"name":"Department of Clinical Physiology and Nuclear Medicine, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bent","family":"Kristensen","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Herlev and Gentofte Hospital, Herlev, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Finn Noe","family":"Bennedb\u00e6k","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Medicine, Herlev and Gentofte Hospital, Herlev, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Zerahn","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Herlev and Gentofte Hospital, Herlev, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"bib1","series-title":"Lancet","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/S0140-6736(09)60507-9","article-title":"Hyperparathyroidism","volume":"374","author":"Fraser","year":"2009","unstructured":"Fraser WDHyperparathyroidism. Lancet2009374145\u2013158. (https:\/\/doi.org\/10.1016\/S0140-6736(0960507-9)10.1016\/S0140-6736(09)60507-9"},{"key":"bib2","article-title":"Danish Endocrine Society. Treatment guideline for primary hyperparathyroidism","year":"2018","unstructured":"Danish Endocrine Society. Treatment guideline for primary hyperparathyroidism. 2018. (available at: https:\/\/endocrinology.dk\/nbv\/calcium-og-knoglemetabolisme\/primaer-hyperparathyreoidisme\/)"},{"key":"bib3","series-title":"Journal of Nuclear Medicine Technology","doi-asserted-by":"publisher","first-page":"111","DOI":"10.2967\/jnmt.112.105122","article-title":"SNM practice guideline for parathyroid scintigraphy 4.0","volume":"40","author":"Greenspan","year":"2012","unstructured":"Greenspan BSDillehay GIntenzo CLavely WCO\u2019Doherty MPalestro CJScheve WStabin MGSylvestros DTulchinsky M. SNM practice guideline for parathyroid scintigraphy 4.0. Journal of Nuclear Medicine Technology201240111\u2013118. 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