{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:17:20Z","timestamp":1784557040999,"version":"3.55.0"},"reference-count":57,"publisher":"Bioscientifica","issue":"6","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["ec.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,6,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Potential influences of parathyroidectomy (PTx) on the quality of life (QoL) in multiple endocrine neoplasia type 1-related primary hyperparathyroidism (HPT\/MEN1) are unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Short Form 36 Health Survey Questionnaire was prospectively applied to 30 HPT\/MEN1 patients submitted to PTx (20, subtotal; 10, total with autograft) before, 6 and 12 months after surgery. Parameters that were analyzed included QoL, age, HPT-related symptoms, general pain, comorbidities, biochemical\/hormonal response, PTx type and parathyroid volume.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Asymptomatic patients were younger (30 vs 38 years;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.04) and presented higher QoL scores than symptomatic ones: Physical Component Summary score (PCS) 92.5 vs 61.2,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.0051; Mental Component Summary score (MCS) 82.0 vs 56.0,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.04. In both groups, QoL remained stable 1 year after PTx, independently of the number of comorbidities. Preoperative general pain was negatively correlated with PCS (r\u2009=\u2009\u22120.60,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.0004) and MCS (r\u2009=\u2009\u22120.57,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.0009). Also, moderate\/intense pain was progressively (6\/12 months) more frequent in cases developing hypoparathyroidism. The PTx type and hypoparathyroidism did not affect the QoL at 12 months although remnant parathyroid tissue volume did have a positive correlation (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.0490; r\u2009=\u20090.3625) to PCS 12 months after surgery. Patients with one to two comorbidities had as pre-PTx PCS (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.0015) as 12 months and post-PTx PCS (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.0031) and MCS (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.0365) better than patients with three to four comorbidities.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A variable QoL profile was underscored in HPT\/MEN1 reflecting multiple factors associated with this complex disorder as comorbidities, advanced age at PTx and presence of preoperative symptoms or of general pain perception. Our data encourage the early indication of PTx in HPT\/MEN1 by providing known metabolic benefits to target organs and avoiding potential negative impact on QoL.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1530\/ec-22-0021","type":"journal-article","created":{"date-parts":[[2022,5,18]],"date-time":"2022-05-18T07:20:46Z","timestamp":1652858446000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-10","source":"Crossref","is-referenced-by-count":4,"title":["Impact of parathyroidectomy on quality of life in multiple endocrine neoplasia type 1"],"prefix":"10.1530","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1988-8543","authenticated-orcid":true,"given":"Mar\u00edlia D\u2019Elboux Guimar\u00e3es","family":"Brescia","sequence":"first","affiliation":[{"name":"Endocrine Genetics Unit (LIM-25), Endocrinology Division, University of S\u00e3o Paulo School of Medicine (FMUSP), Faculdade de Medicina da Universidade de S\u00e3o Paulo (FMUSP), Hospital das Clinicas (HCFMUSP), S\u00e3o Paulo, S\u00e3o Paulo, Brazil"},{"name":"Parathyroid Unit \u2013 LIM-28, Laborat\u00f3rio de Cirurgia de Cabe\u00e7a e Pesco\u00e7o, Division of Head and Neck Surgery, Department of Surgery, Hospital das Clinicas (HCFMUSP), University of S\u00e3o Paulo School of Medicine (FMUSP), Faculdade de Medicina, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karine Candido","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Endocrine Genetics Unit (LIM-25), Endocrinology Division, University of S\u00e3o Paulo School of Medicine (FMUSP), Faculdade de Medicina da Universidade de S\u00e3o Paulo (FMUSP), Hospital das Clinicas (HCFMUSP), S\u00e3o Paulo, S\u00e3o Paulo, Brazil"},{"name":"Endocrine Oncology Division, Institute of Cancer of the State of S\u00e3o Paulo (ICESP), University of S\u00e3o Paulo School of Medicine (FMUSP), Faculdade de Medicina da Universidade de S\u00e3o Paulo (FMUSP), S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9 Fernandes","family":"d\u2019Alessandro","sequence":"additional","affiliation":[{"name":"Parathyroid Unit \u2013 LIM-28, Laborat\u00f3rio de Cirurgia de Cabe\u00e7a e Pesco\u00e7o, Division of Head and Neck Surgery, Department of Surgery, Hospital das Clinicas (HCFMUSP), University of S\u00e3o Paulo School of Medicine (FMUSP), Faculdade de Medicina, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wellington","family":"Alves Filho","sequence":"additional","affiliation":[{"name":"Department of Surgery, Walter Cantidio University Hospital, Federal University of Ceara School of Medicine (FAMED-UFC), Fortaleza, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willemijn Y","family":"van der Plas","sequence":"additional","affiliation":[{"name":"Department of Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Schelto","family":"Kruijff","sequence":"additional","affiliation":[{"name":"Department of Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio Samir","family":"Arap","sequence":"additional","affiliation":[{"name":"Parathyroid Unit \u2013 LIM-28, Laborat\u00f3rio de Cirurgia de Cabe\u00e7a e Pesco\u00e7o, Division of Head and Neck Surgery, Department of Surgery, Hospital das Clinicas (HCFMUSP), University of S\u00e3o Paulo School of Medicine (FMUSP), Faculdade de Medicina, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio Pereira de Almeida","family":"Toledo","sequence":"additional","affiliation":[{"name":"Endocrine Genetics Unit (LIM-25), Endocrinology Division, University of S\u00e3o Paulo School of Medicine (FMUSP), Faculdade de Medicina da Universidade de S\u00e3o Paulo (FMUSP), Hospital das Clinicas (HCFMUSP), S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5749-2363","authenticated-orcid":true,"given":"F\u00e1bio Luiz de Menezes","family":"Montenegro","sequence":"additional","affiliation":[{"name":"Parathyroid Unit \u2013 LIM-28, Laborat\u00f3rio de Cirurgia de Cabe\u00e7a e Pesco\u00e7o, Division of Head and Neck Surgery, Department of Surgery, Hospital das Clinicas (HCFMUSP), University of S\u00e3o Paulo School of Medicine (FMUSP), Faculdade de Medicina, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1147-4159","authenticated-orcid":true,"given":"Delmar Muniz","family":"Louren\u00e7o","sequence":"additional","affiliation":[{"name":"Endocrine Genetics Unit (LIM-25), Endocrinology Division, University of S\u00e3o Paulo School of Medicine (FMUSP), Faculdade de Medicina da Universidade de S\u00e3o Paulo (FMUSP), Hospital das Clinicas (HCFMUSP), S\u00e3o Paulo, S\u00e3o Paulo, Brazil"},{"name":"Endocrine Oncology Division, Institute of Cancer of the State of S\u00e3o Paulo (ICESP), University of S\u00e3o Paulo School of Medicine (FMUSP), Faculdade de Medicina da Universidade de S\u00e3o Paulo (FMUSP), S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"bib1","series-title":"Journal of Clinical Endocrinology and 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