{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:16:37Z","timestamp":1784556997910,"version":"3.55.0"},"reference-count":20,"publisher":"Bioscientifica","issue":"6","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["ec.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,6,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Most studies reporting posterior pituitary tumors (PPTs) are small case series or single cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with a histological diagnosis of PPT from January 2010 to December 2021 in a tertiary center were identified. We reported clinical symptoms, endocrine assessments, radiological and pathological features, and surgical outcomes of PPTs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 51 patients (23 males, 51.3 \u00b1 10.3 years old) with PPT were included in this study. Major symptoms were visual defects, headache, and hypopituitarism, while diabetes insipidus was uncommon (9.8%). The typical radiological feature was homogeneous enhancement (84.3%) of a regular-shaped mass on T1 contrast imaging without cystic change, calcification, or cavernous sinus invasion. We achieved gross total resection in 38\/51 patients (74.5%). Pathologically, all tumors showed thyroid transcription factor 1 immunoreactivity. Among 29 patients with suprasellar PPTs, postoperative hemorrhage due to tumor residue was encountered in 2\/15 cases in the transcranial group and 0\/14 in the endoscopy group. Patients with spindle cell oncocytoma (SCO) were more likely to be surgically treated (25% vs 0%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.018), harbor a higher Ki-67 index (16.7% vs 0% &gt; 5%\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.050), and present a lower 2-year recurrence-free survival rate (67.5% vs 90.9%) compared with patients with pituicytoma or granular cell tumor.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PPTs should be considered in the differential diagnosis of patients with sellar and suprasellar masses with a regular lesion with homogeneous enhancement. SCOs had high proliferation activity and risk of recurrence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1530\/ec-22-0188","type":"journal-article","created":{"date-parts":[[2022,5,13]],"date-time":"2022-05-13T12:47:20Z","timestamp":1652446040000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-10","source":"Crossref","is-referenced-by-count":7,"title":["Recommendation to improve the WHO classification of posterior pituitary tumors as a unique entity: evidence from a large case series"],"prefix":"10.1530","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5478-3555","authenticated-orcid":true,"given":"Nidan","family":"Qiao","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai, China"},{"name":"National Center for Neurological Disorders, Shanghai, China"},{"name":"Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China"},{"name":"Neurosurgical Institute of Fudan University, Shanghai, China"},{"name":"Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haixia","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Pathology, Huashan Hospital, Shanghai Medical School, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoyun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Huashan Hospital, Shanghai Medical School, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongying","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Huashan Hospital, Shanghai Medical School, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai, China"},{"name":"National Center for Neurological Disorders, Shanghai, China"},{"name":"Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China"},{"name":"Neurosurgical Institute of Fudan University, Shanghai, China"},{"name":"Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuefei","family":"Shou","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai, China"},{"name":"National Center for Neurological Disorders, Shanghai, China"},{"name":"Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China"},{"name":"Neurosurgical Institute of Fudan University, Shanghai, China"},{"name":"Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyun","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai, China"},{"name":"National Center for Neurological Disorders, Shanghai, China"},{"name":"Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China"},{"name":"Neurosurgical Institute of Fudan University, Shanghai, China"},{"name":"Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai, China"},{"name":"National Center for Neurological Disorders, Shanghai, China"},{"name":"Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China"},{"name":"Neurosurgical Institute 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