{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:16:44Z","timestamp":1784557004408,"version":"3.55.0"},"reference-count":36,"publisher":"Bioscientifica","issue":"12","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["ec.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,12,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Growth hormone (GH) and insulin-like growth factors (IGFs) are not mandatory for reproductive life, but data suggest their synergistic action with follicle-stimulating hormone throughout ovarian folliculogenesis. We aimed to evaluate the association of IGF-1 level on clinical pregnancy rate after ovarian stimulation, with or without intrauterine insemination, in women with GH deficiency (GHD) treated with GH replacement therapy (GHRT) at conception.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design and methods<\/jats:title>\n                    <jats:p>\n                      Data from 19 women with both GHD and hypogonadotropic hypogonadism referred to our reproductive medicine department were retrospectively collected. IGF-1 levels were assessed in a single laboratory, and values were expressed in\n                      <jats:sc>s.d.<\/jats:sc>\n                      from the mean.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Amongst the seven patients receiving GHRT during ovarian stimulation, higher IGF-1 levels were significantly associated with clinical pregnancy (+0.4\n                      <jats:sc>s.d.<\/jats:sc>\n                      vs\u20131.6\n                      <jats:sc>s.d.<\/jats:sc>\n                      ,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.03). Amongst the 24 pregnancies obtained by the 19 infertile patients, pregnancy loss was less frequent with the addition of GHRT than without (1 miscarriage out of 8 total pregnancies vs 4 miscarriages out of 16 total pregnancies).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      This is the first study evaluating the association of IGF-1 level on clinical pregnancy rate in GH-treated women at conception. When taking care of female infertility due to hypogonadotropic hypogonadism, practitioners should enquire about the associated GHD and IGF-1 levels. To ensure higher clinical pregnancy chances, practitioners should aim for IGF-1 values at conception, ranging from 0\n                      <jats:sc>s.d.<\/jats:sc>\n                      to +2\n                      <jats:sc>s.d.<\/jats:sc>\n                      , and, if necessary, could discuss initiation or increase GH treatment. Prospective studies should help strengthen our results.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1530\/ec-22-0241","type":"journal-article","created":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T16:36:01Z","timestamp":1665506161000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-10","source":"Crossref","is-referenced-by-count":2,"title":["Normal-high IGF-1 level improves pregnancy rate after ovarian stimulation in women treated with growth hormone replacement therapy"],"prefix":"10.1530","volume":"11","author":[{"given":"Nathalie","family":"Ly","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Reproductive Medicine, Reference Center for Rare Endocrine Diseases of Growth and Development, Reference Center for Gynecological Rare Diseases, H\u00f4pitaux Universitaires Piti\u00e9 Salp\u00eatri\u00e8re-Charles Foix, Paris, France"},{"name":"EndoERN, APHP Consortium Pitie Salpetriere Hospital, Necker Hospital, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Dubreuil","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Reproductive Medicine, Reference Center for Rare Endocrine Diseases of Growth and Development, Reference Center for Gynecological Rare Diseases, H\u00f4pitaux Universitaires Piti\u00e9 Salp\u00eatri\u00e8re-Charles Foix, Paris, France"},{"name":"EndoERN, APHP Consortium Pitie Salpetriere Hospital, Necker Hospital, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8462-7753","authenticated-orcid":true,"given":"Philippe","family":"Touraine","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Reproductive Medicine, Reference Center for Rare Endocrine Diseases of Growth and Development, Reference Center for Gynecological Rare Diseases, H\u00f4pitaux Universitaires Piti\u00e9 Salp\u00eatri\u00e8re-Charles Foix, Paris, France"},{"name":"EndoERN, APHP Consortium Pitie Salpetriere Hospital, Necker Hospital, Paris, France"},{"name":"Sorbonne University, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"bib1","series-title":"Nature Reviews: Endocrinology","first-page":"285","article-title":"Growth hormone \u2013 past, present and future","volume":"14","author":"Ranke","year":"2018","unstructured":"Ranke MBWit JM. 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