{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:16:44Z","timestamp":1784557004635,"version":"3.55.0"},"reference-count":63,"publisher":"Bioscientifica","issue":"8","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["ec.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,8,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Children with suprasellar brain damage are at risk of hypothalamic dysfunction (HD). HD may lead to decreased resting energy expenditure (REE). Decreased REE, however, is not present in all children with HD. Our aim was to assess which children suspect for HD have low REE, and its association with clinical severity of HD or radiological hypothalamic damage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods<\/jats:title>\n                    <jats:p>A retrospective cohort study was performed. Measured REE (mREE) of children at risk of HD was compared to predicted REE (pREE). Low REE was defined as mREE &lt;90% of predicted. The mREE\/pREE quotient was associated to a clinical score for HD symptoms and to radiological hypothalamic damage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total, 67 children at risk of HD (96% brain tumor diagnosis) with a mean BMI SDS of +2.3 \u00b1 1.0 were included. Of these, 45 (67.2%) had low mREE. Children with severe HD had a significant lower mean mREE\/pREE quotient compared to children with no, mild, or moderate HD. Mean mREE\/pREE quotient of children with posterior hypothalamic damage was significantly lower compared to children with no or anterior damage. Tumor progression or tumor recurrence, severe clinical HD, and panhypopituitarism with diabetes insipidus (DI) were significant risk factors for reduced REE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>REE may be lowered in children with hypothalamic damage and is associated to the degree of clinical HD. REE is, however, not lowered in all children suspect for HD. For children with mild or moderate clinical HD symptoms, REE measurements may be useful to distinguish between those who may benefit from obesity treatment that increases REE from those who would be better helped using other obesity interventions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1530\/ec-22-0276","type":"journal-article","created":{"date-parts":[[2022,6,28]],"date-time":"2022-06-28T09:24:44Z","timestamp":1656408284000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-10","source":"Crossref","is-referenced-by-count":12,"title":["Resting energy expenditure in children at risk of hypothalamic dysfunction"],"prefix":"10.1530","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3606-6592","authenticated-orcid":true,"given":"J","family":"Van Schaik","sequence":"first","affiliation":[{"name":"Division of Pediatric Endocrinology, Wilhelmina Children\u2019s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands"},{"name":"Division of Pediatric Oncology, Princess M\u00e1xima Center for Pediatric Oncology, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Burghard","sequence":"additional","affiliation":[{"name":"Division of Pediatric Oncology, Princess M\u00e1xima Center for Pediatric Oncology, Utrecht, The Netherlands"},{"name":"Department of Exercise Physiology, Child Development & Exercise Center, Wilhelmina Children\u2019s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M H","family":"Lequin","sequence":"additional","affiliation":[{"name":"Division of Pediatric Oncology, Princess M\u00e1xima Center for Pediatric Oncology, Utrecht, The Netherlands"},{"name":"Department of Radiology, Wilhelmina Children\u2019s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E A","family":"van Maren","sequence":"additional","affiliation":[{"name":"Division of Pediatric Oncology, Princess M\u00e1xima Center for Pediatric Oncology, Utrecht, The Netherlands"},{"name":"Department of Radiology, Wilhelmina Children\u2019s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A M","family":"van Dijk","sequence":"additional","affiliation":[{"name":"Department of Dietetics, University Medical Center Utrecht, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Takken","sequence":"additional","affiliation":[{"name":"Division of Pediatric Oncology, Princess M\u00e1xima Center for Pediatric Oncology, Utrecht, The Netherlands"},{"name":"Department of Exercise Physiology, Child Development & Exercise Center, Wilhelmina Children\u2019s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L B","family":"Rehorst-Kleinlugtenbelt","sequence":"additional","affiliation":[{"name":"Division of Pediatric Oncology, Princess M\u00e1xima Center for Pediatric Oncology, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0229-1123","authenticated-orcid":true,"given":"B","family":"Bakker","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology, Wilhelmina Children\u2019s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands"},{"name":"Division of Pediatric Oncology, Princess M\u00e1xima Center for Pediatric Oncology, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Meijer","sequence":"additional","affiliation":[{"name":"Division of Pediatric Oncology, Princess M\u00e1xima Center for Pediatric Oncology, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E W","family":"Hoving","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Princess M\u00e1xima Center for Pediatric Oncology, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Fiocco","sequence":"additional","affiliation":[{"name":"Division of Pediatric Oncology, Princess M\u00e1xima Center for Pediatric Oncology, Utrecht, The Netherlands"},{"name":"Institute of Mathematics, Leiden University, Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A Y N","family":"Schouten-van Meeteren","sequence":"additional","affiliation":[{"name":"Division of Pediatric Oncology, Princess M\u00e1xima Center for Pediatric Oncology, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W J E","family":"Tissing","sequence":"additional","affiliation":[{"name":"Division of Pediatric Oncology, Princess M\u00e1xima Center for Pediatric Oncology, Utrecht, The Netherlands"},{"name":"Division of Pediatric Oncology, University Medical Centre Groningen, Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H M","family":"van Santen","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology, Wilhelmina Children\u2019s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands"},{"name":"Division of Pediatric Oncology, Princess M\u00e1xima Center for Pediatric Oncology, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"bib1","series-title":"Frontiers in Endocrinology","article-title":"Hypothalamic obesity in patients with craniopharyngioma: profound changes of several weight regulatory circuits","volume":"2","author":"Roth","year":"2011","unstructured":"Roth CLHypothalamic obesity in patients with craniopharyngioma: profound changes of several weight regulatory circuits. Frontiers in Endocrinology20112 49. (https:\/\/doi.org\/10.3389\/fendo.2011.00049)22654811"},{"key":"bib2","series-title":"Endocrine Reviews","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1210\/er.2013-1115","article-title":"Craniopharyngioma","volume":"35","author":"Muller","year":"2014","unstructured":"Muller HLCraniopharyngioma. Endocrine Reviews201435513\u2013543. (https:\/\/doi.org\/10.1210\/er.2013-1115)10.1210\/er.2013-111521846381"},{"key":"bib3","series-title":"Italian Journal of Pediatrics","article-title":"Obesity and craniopharyngioma","volume":"37","author":"Iughetti","year":"2011","unstructured":"Iughetti LBruzzi P. Obesity and craniopharyngioma. Italian Journal of Pediatrics201137 38. (https:\/\/doi.org\/10.1186\/1824-7288-37-38)22654817"},{"key":"bib4","series-title":"Frontiers in Endocrinology","article-title":"Hypothalamic obesity after craniopharyngioma: mechanisms, diagnosis, and treatment","volume":"2","author":"Lustig","year":"2011","unstructured":"Lustig RHHypothalamic obesity after craniopharyngioma: mechanisms, diagnosis, and treatment. Frontiers in Endocrinology20112 60. (https:\/\/doi.org\/10.3389\/fendo.2011.00060)26124708"},{"key":"bib5","series-title":"Endocrine Reviews","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1210\/er.2018-00017","article-title":"Pathophysiology and individualized treatment of hypothalamic obesity following craniopharyngioma and other suprasellar tumors: a systematic review","volume":"40","author":"van Iersel","year":"2019","unstructured":"van Iersel LBrokke KEAdan RAHBulthuis LCMvan den Akker ELTvan Santen HM. Pathophysiology and individualized treatment of hypothalamic obesity following craniopharyngioma and other suprasellar tumors: a systematic review. Endocrine Reviews201940193\u2013235. (https:\/\/doi.org\/10.1210\/er.2018-00017)10.1210\/er.2018-0001726973721"},{"key":"bib6","series-title":"Frontiers in Systems Neuroscience","article-title":"Lateral hypothalamus, nucleus accumbens, and ventral pallidum roles in eating and hunger: interactions between homeostatic and reward circuitry","volume":"9","author":"Castro","year":"2015","unstructured":"Castro DCCole SLBerridge KC. Lateral hypothalamus, nucleus accumbens, and ventral pallidum roles in eating and hunger: interactions between homeostatic and reward circuitry. Frontiers in Systems Neuroscience20159 90. (https:\/\/doi.org\/10.3389\/fnsys.2015.00090)"},{"key":"bib7","series-title":"Cancer","doi-asserted-by":"publisher","first-page":"3034","DOI":"10.1002\/cncr.25051","article-title":"Physical performance limitations among adult survivors of childhood brain tumors","volume":"116","author":"Ness","year":"2010","unstructured":"Ness KKMorris EBNolan VGHowell CRGilchrist LSStovall MCox CLKlosky JLGajjar ANeglia JP. Physical performance limitations among adult survivors of childhood brain tumors. Cancer20101163034\u20133044. (https:\/\/doi.org\/10.1002\/cncr.25051)10.1002\/cncr.2505126203601"},{"key":"bib8","series-title":"International Journal of Child Health and Nutrition","first-page":"44","article-title":"Do childhood cancer survivors meet the diet and physical activity guidelines? A review of guidelines and literature","volume":"1","author":"Zhang","year":"2012","unstructured":"Zhang FFSaltzman EMust AParsons SK. Do childhood cancer survivors meet the diet and physical activity guidelines? A review of guidelines and literature. International Journal of Child Health and Nutrition2012144\u201358. (https:\/\/doi.org\/10.6000\/1929-4247.2012.01.01.06)"},{"key":"bib9","series-title":"Annals of Behavioral Medicine","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1007\/s12160-010-9192-6","article-title":"Diet and physical activity in childhood cancer survivors: a review of the literature","volume":"39","author":"Stolley","year":"2010","unstructured":"Stolley MRRestrepo JSharp LK. Diet and physical activity in childhood cancer survivors: a review of the literature. Annals of Behavioral Medicine201039232\u2013249. (https:\/\/doi.org\/10.1007\/s12160-010-9192-6)10.1007\/s12160-010-9192-616562585"},{"key":"bib10","series-title":"Endocrinologist","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1097\/01.ten.0000098611.49230.10","article-title":"Endocrinopathies in childhood cancer survivors","volume":"13","author":"Rose","year":"2003","unstructured":"Rose SREndocrinopathies in childhood cancer survivors. Endocrinologist200313488\u2013495. (https:\/\/doi.org\/10.1097\/01.ten.0000098611.49230.10)10.1097\/01.ten.0000098611.49230.1022649386"},{"key":"bib11","series-title":"Clinical Nutrition","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1016\/j.clnu.2013.06.003","article-title":"Changes in weight after traumatic brain injury in adult patients: a longitudinal study","volume":"33","author":"Crenn","year":"2014","unstructured":"Crenn PHamchaoui SBourget-Massari AHanachi MMelchior JCAzouvi P. Changes in weight after traumatic brain injury in adult patients: a longitudinal study. Clinical Nutrition201433348\u2013353. (https:\/\/doi.org\/10.1016\/j.clnu.2013.06.003)10.1016\/j.clnu.2013.06.003"},{"key":"bib12","series-title":"Clinical Endocrinology","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1111\/cen.13929","article-title":"Management of hypothalamic disease in patients with craniopharyngioma","volume":"90","author":"Thompson","year":"2019","unstructured":"Thompson CJCostello RWCrowley RK. Management of hypothalamic disease in patients with craniopharyngioma. Clinical Endocrinology201990506\u2013516. (https:\/\/doi.org\/10.1111\/cen.13929)10.1111\/cen.13929"},{"key":"bib13","series-title":"Hormone Research in Paediatrics","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1159\/000496564","article-title":"Hypothalamic obesity: prologue and promise","volume":"91","author":"Abuzzahab","year":"2019","unstructured":"Abuzzahab MJRoth CLShoemaker AH. Hypothalamic obesity: prologue and promise. Hormone Research in Paediatrics201991128\u2013136. (https:\/\/doi.org\/10.1159\/000496564)10.1159\/00049656417591624"},{"key":"bib14","series-title":"Helvetica Paediatrica Acta","first-page":"489","article-title":"Hyperphagia, obesity and diabetes insipidus due to hypothalamic lesion in a girl","volume":"27","author":"Heldenberg","year":"1972","unstructured":"Heldenberg DTamir IAshner MWerbin B. Hyperphagia, obesity and diabetes insipidus due to hypothalamic lesion in a girl. Helvetica Paediatrica Acta197227489\u2013494."},{"key":"bib15","series-title":"Journal of Clinical Endocrinology and Metabolism","doi-asserted-by":"publisher","first-page":"5395","DOI":"10.1210\/jc.2010-0993","article-title":"Reduced energy expenditure and impaired feeding-related signals but not high energy intake reinforces hypothalamic obesity in adults with childhood onset craniopharyngioma","volume":"95","author":"Holmer","year":"2010","unstructured":"Holmer HPozarek GWirfalt EPopovic VEkman BBjork JErfurth EM. Reduced energy expenditure and impaired feeding-related signals but not high energy intake reinforces hypothalamic obesity in adults with childhood onset craniopharyngioma. Journal of Clinical Endocrinology and Metabolism2010955395\u20135402. (https:\/\/doi.org\/10.1210\/jc.2010-0993)10.1210\/jc.2010-0993"},{"key":"bib16","series-title":"Endocrinologist","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1097\/00019616-200205000-00008","article-title":"Hypothalamic obesity: the sixth cranial endocrinopathy","volume":"12","author":"Lustig","year":"2002","unstructured":"Lustig RHHypothalamic obesity: the sixth cranial endocrinopathy. Endocrinologist200212210\u2013217. (https:\/\/doi.org\/10.1097\/00019616-200205000-00008)10.1097\/00019616-200205000-00008"},{"key":"bib17","series-title":"Indian Journal of Endocrinology and Metabolism","doi-asserted-by":"publisher","first-page":"594","DOI":"10.4103\/ijem.IJEM_484_16","article-title":"Indirect calorimetry: from bench to bedside","volume":"21","author":"Gupta","year":"2017","unstructured":"Gupta RDRamachandran RVenkatesan PAnoop SJoseph MThomas N. Indirect calorimetry: from bench to bedside. Indian Journal of Endocrinology and Metabolism201721594\u2013599. (https:\/\/doi.org\/10.4103\/ijem.IJEM_484_16)10.4103\/ijem.IJEM_484_16"},{"key":"bib18","series-title":"Journal of Pediatric Endocrinology and Metabolism","first-page":"1305","article-title":"Comparison of energy expenditure, body composition, metabolic disorders, and energy intake between obese children with a history of craniopharyngioma and children with multifactorial obesity","volume":"28","author":"Bomer","year":"2015","unstructured":"Bomer ISaure CCaminiti CRamos JGZuccaro GBrea MBravo MMaza C. Comparison of energy expenditure, body composition, metabolic disorders, and energy intake between obese children with a history of craniopharyngioma and children with multifactorial obesity. Journal of Pediatric Endocrinology and Metabolism2015281305\u20131312. (https:\/\/doi.org\/10.1515\/jpem-2015-0167)25431867"},{"issue":"1","key":"bib19","series-title":"Journal of Neurosurgery","first-page":"3","article-title":"Pediatric craniopharyngiomas: classification and treatment according to the degree of hypothalamic involvement","volume":"106","author":"Puget","year":"2007","unstructured":"Puget SGarnett MWray AGrill JHabrand JLBodaert NZerah MBezerra MRenier DPierre-Kahn APediatric craniopharyngiomas: classification and treatment according to the degree of hypothalamic involvement. Journal of Neurosurgery2007106 (1Supplement) 3\u201312. (https:\/\/doi.org\/10.3171\/ped.2007.106.1.3)25381948"},{"key":"bib20","series-title":"European Journal of Endocrinology","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1530\/EJE-11-0158","article-title":"Post-operative hypothalamic lesions and obesity in childhood craniopharyngioma: results of the multinational prospective trial KRANIOPHARYNGEOM 2000 after 3-year follow-up","volume":"165","author":"Muller","year":"2011","unstructured":"Muller HLGebhardt UTeske CFaldum AZwiener IWarmuth-Metz MPietsch TPohl FSorensen NCalaminus GPost-operative hypothalamic lesions and obesity in childhood craniopharyngioma: results of the multinational prospective trial KRANIOPHARYNGEOM 2000 after 3-year follow-up. European Journal of Endocrinology201116517\u201324. (https:\/\/doi.org\/10.1530\/EJE-11-0158)10.1530\/EJE-11-015822654811"},{"key":"bib21","series-title":"Archives of Pediatrics and Adolescent Medicine","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1001\/archpedi.156.9.887","article-title":"The use of dextroamphetamine to treat obesity and hyperphagia in children treated for craniopharyngioma","volume":"156","author":"Mason","year":"2002","unstructured":"Mason PWKrawiecki NMeacham LR. The use of dextroamphetamine to treat obesity and hyperphagia in children treated for craniopharyngioma. Archives of Pediatrics and Adolescent Medicine2002156887\u2013892. (https:\/\/doi.org\/10.1001\/archpedi.156.9.887)10.1001\/archpedi.156.9.88721846381"},{"key":"bib22","series-title":"Journal of Pediatric Endocrinology and Metabolism","first-page":"129","article-title":"Dexamphetamine use for management of obesity and hypersomnolence following hypothalamic injury","volume":"19","author":"Ismail","year":"2006","unstructured":"Ismail DO'Connell MAZacharin MR. Dexamphetamine use for management of obesity and hypersomnolence following hypothalamic injury. Journal of Pediatric Endocrinology and Metabolism200619129\u2013134. (https:\/\/doi.org\/10.1515\/jpem.2006.19.2.129)22654817"},{"key":"bib23","series-title":"Frontiers in Endocrinology","article-title":"Effects of methylphenidate on weight gain and food intake in hypothalamic obesity","volume":"2","author":"Elfers","year":"2011","unstructured":"Elfers CTRoth CL. Effects of methylphenidate on weight gain and food intake in hypothalamic obesity. Frontiers in Endocrinology20112 78. (https:\/\/doi.org\/10.3389\/fendo.2011.00078)26124708"},{"key":"bib24","series-title":"Frontiers in Endocrinology","doi-asserted-by":"publisher","first-page":"845937","DOI":"10.3389\/fendo.2022.845937","article-title":"Dextroamphetamine treatment in children with hypothalamic obesity","volume":"13","author":"van Schaik","year":"2022","unstructured":"van Schaik JWelling MSde Groot CJvan Eck JPJuriaans ABurghard MOude Ophuis SBJBakker BTissing WJESchouten-van Meeteren AYNDextroamphetamine treatment in children with hypothalamic obesity. Frontiers in Endocrinology202213845937. (https:\/\/10.3389\/fendo.2022.845937)10.3389\/fendo.2022.84593726973721"},{"key":"bib25","series-title":"Obesity Facts","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1159\/000495851","article-title":"Treatment of hypothalamic obesity with dextroamphetamine: a case series","volume":"12","author":"Denzer","year":"2019","unstructured":"Denzer CDenzer FLennerz BSVollbach HLustig RHWabitsch M. Treatment of hypothalamic obesity with dextroamphetamine: a case series. Obesity Facts20191291\u2013102. (https:\/\/doi.org\/10.1159\/000495851)10.1159\/000495851"},{"key":"bib26","series-title":"Journal of Parenteral and Enteral Nutrition","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1177\/0148607114526242","article-title":"Validity test of a new open-circuit indirect calorimeter","volume":"39","author":"Ashcraft","year":"2015","unstructured":"Ashcraft CMFrankenfield DC. Validity test of a new open-circuit indirect calorimeter. Journal of Parenteral and Enteral Nutrition201539738\u2013742. (https:\/\/doi.org\/10.1177\/0148607114526242)10.1177\/014860711452624226203601"},{"key":"bib27","series-title":"Nutrients","doi-asserted-by":"publisher","first-page":"4308","DOI":"10.3390\/nu13124308","article-title":"Inter-day reliability of resting metabolic rate and maximal fat oxidation during exercise in healthy men using the Ergostik gas analyzer","volume":"13","author":"Robles-Gonzalez","year":"2021","unstructured":"Robles-Gonzalez LGutierrez-Hellin JAguilar-Navarro MRuiz-Moreno CMunoz ADel-Coso JRuiz JRAmaro-Gahete FJ. Inter-day reliability of resting metabolic rate and maximal fat oxidation during exercise in healthy men using the Ergostik gas analyzer. Nutrients2021134308. (https:\/\/doi.org\/10.3390\/nu13124308)10.3390\/nu13124308"},{"key":"bib28","series-title":"Clinical Nutrition ESPEN","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.clnesp.2019.05.004","article-title":"In vitro validation of indirect calorimetry device developed for the ICALIC project against mass spectrometry","volume":"32","author":"Oshima","year":"2019","unstructured":"Oshima TDupertuis YMDelsoglio MGraf SHeidegger CPPichard C. In vitro validation of indirect calorimetry device developed for the ICALIC project against mass spectrometry. Clinical Nutrition ESPEN20193250\u201355. (https:\/\/doi.org\/10.1016\/j.clnesp.2019.05.004)10.1016\/j.clnesp.2019.05.00416562585"},{"key":"bib29","series-title":"Clinical Nutrition","doi-asserted-by":"publisher","first-page":"1927","DOI":"10.1016\/j.clnu.2019.08.017","article-title":"Evaluation of the accuracy and precision of a new generation indirect calorimeter in canopy dilution mode","volume":"39","author":"Delsoglio","year":"2020","unstructured":"Delsoglio MDupertuis YMOshima Tvan der Plas MPichard C. Evaluation of the accuracy and precision of a new generation indirect calorimeter in canopy dilution mode. Clinical Nutrition2020391927\u20131934. (https:\/\/doi.org\/10.1016\/j.clnu.2019.08.017)10.1016\/j.clnu.2019.08.01722649386"},{"key":"bib30","series-title":"Journal of Physiology","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1113\/jphysiol.1949.sp004363","article-title":"New methods for calculating metabolic rate with special reference to protein metabolism","volume":"109","author":"Weir","year":"1949","unstructured":"Weir JBNew methods for calculating metabolic rate with special reference to protein metabolism. Journal of Physiology19491091\u20139. (https:\/\/doi.org\/10.1113\/jphysiol.1949.sp004363)10.1113\/jphysiol.1949.sp004363"},{"key":"bib31","series-title":"e-SPEN","doi-asserted-by":"publisher","first-page":"e7","DOI":"10.1016\/j.eclnm.2010.12.001","article-title":"A new indirect calorimeter is accurate and reliable for measuring basal energy expenditure, thermic effect of food and substrate oxidation in obese and healthy subjects","volume":"6","author":"Blond","year":"2011","unstructured":"Blond EMaitrepierre CNormand SSothier MRoth HGoudable JLaville M. A new indirect calorimeter is accurate and reliable for measuring basal energy expenditure, thermic effect of food and substrate oxidation in obese and healthy subjects. e-SPEN20116e7\u2013e15. (https:\/\/doi.org\/10.1016\/j.eclnm.2010.12.001)10.1016\/j.eclnm.2010.12.001"},{"key":"bib32","series-title":"Acta Oncologica","first-page":"239","article-title":"FEC mobilized stem cells for high-dose therapy in breast cancer patients. SB6 9401 Study Group","volume":"38","author":"Lindman","year":"1999","unstructured":"Lindman HWiklund THolte HLjungman PBlomqvist CKvalheim GBengtsson MHoglund MWilking NBergh J. FEC mobilized stem cells for high-dose therapy in breast cancer patients. SB6 9401 Study Group. Acta Oncologica199938239\u2013245. (https:\/\/doi.org\/10.1080\/028418699431672)17591624"},{"key":"bib33","series-title":"Report of a joint FAO\/WHO\/UNU Expert Consultation","article-title":"Energy and protein requirements","year":"1985","unstructured":"World Health Organization. Energy and protein requirements. In Report of a joint FAO\/WHO\/UNU Expert Consultation. World Health Organization Technical Report Series 724, 1985."},{"key":"bib34","series-title":"BMJ","doi-asserted-by":"publisher","first-page":"1240","DOI":"10.1136\/bmj.320.7244.1240","article-title":"Establishing a standard definition for child overweight and obesity worldwide: international survey","volume":"320","author":"Cole","year":"2000","unstructured":"Cole TJBellizzi MCFlegal KMDietz WH. Establishing a standard definition for child overweight and obesity worldwide: international survey. BMJ20003201240\u20131243. (https:\/\/doi.org\/10.1136\/bmj.320.7244.1240)10.1136\/bmj.320.7244.1240"},{"key":"bib35","series-title":"BMJ","article-title":"Body mass index cut offs to define thinness in children and adolescents: international survey","volume":"335","author":"Cole","year":"2007","unstructured":"Cole TJFlegal KMNicholls DJackson AA. Body mass index cut offs to define thinness in children and adolescents: international survey. BMJ2007335 194. (https:\/\/doi.org\/10.1136\/bmj.39238.399444.55)"},{"issue":"Supplement 1","key":"bib36","series-title":"Human Nutrition: Clinical Nutrition","first-page":"5","article-title":"Predicting basal metabolic rate, new standards and review of previous work","volume":"39","author":"Schofield","year":"1985","unstructured":"Schofield WNPredicting basal metabolic rate, new standards and review of previous work. Human Nutrition: Clinical Nutrition198539 (Supplement 1) 5\u201341."},{"key":"bib37","series-title":"PNAS","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1073\/pnas.4.12.370","article-title":"A biometric study of human basal metabolism","volume":"4","author":"Harris","year":"1918","unstructured":"Harris JBenedict G. A biometric study of human basal metabolism. PNAS19184370\u2013373. (https:\/\/doi.org\/10.1073\/pnas.4.12.370)10.1073\/pnas.4.12.37025431867"},{"key":"bib38","series-title":"European Journal of Clinical Nutrition","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1038\/sj.ejcn.1600690","article-title":"New equations to estimate basal metabolic rate in children aged 10\u201315 years","volume":"53","author":"Henry","year":"1999","unstructured":"Henry CJKDyer SGhusain-Choueiri A. New equations to estimate basal metabolic rate in children aged 10\u201315 years. European Journal of Clinical Nutrition199953134\u2013142. (https:\/\/doi.org\/10.1038\/sj.ejcn.1600690)10.1038\/sj.ejcn.160069025381948"},{"key":"bib39","series-title":"Public Health Nutrition","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1079\/PHN2005801","article-title":"Basal metabolic rate studies in humans: measurement and development of new equations","volume":"8","author":"Henry","year":"2005","unstructured":"Henry CJKBasal metabolic rate studies in humans: measurement and development of new equations. Public Health Nutrition200581133\u20131152. (https:\/\/doi.org\/10.1079\/phn2005801)10.1079\/PHN2005801"},{"key":"bib40","series-title":"Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein and Amino Acids","year":"2005","unstructured":"Institute of Medicine. Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein and Amino Acids. Washington, DC, USA: The National Academies Press, 2005. (https:\/\/doi.org\/10.17226\/10490)"},{"key":"bib41","series-title":"British Journal of Nutrition","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1017\/BJN20061941","article-title":"Development and cross-validation of prediction equations for estimating resting energy expenditure in severely obese Caucasian children and adolescents","volume":"96","author":"Lazzer","year":"2006","unstructured":"Lazzer SAgosti FDe Col ASartorio A. Development and cross-validation of prediction equations for estimating resting energy expenditure in severely obese Caucasian children and adolescents. British Journal of Nutrition200696973\u2013979. (https:\/\/doi.org\/10.1017\/bjn20061941)10.1017\/BJN20061941"},{"key":"bib42","series-title":"American Journal of Clinical Nutrition","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1093\/ajcn\/51.2.241","article-title":"A new predictive equation for resting energy-expenditure in healthy-individuals","volume":"51","author":"Mifflin","year":"1990","unstructured":"Mifflin MDStjeor STHill LAScott BJDaugherty SAKoh YO. A new predictive equation for resting energy-expenditure in healthy-individuals. American Journal of Clinical Nutrition199051241\u2013247. (https:\/\/doi.org\/10.1093\/ajcn\/51.2.241)10.1093\/ajcn\/51.2.241"},{"key":"bib43","series-title":"Journal of Pediatrics","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1016\/S0022-3476(95)70114-1","article-title":"Measured and predicted resting metabolic-rate in obese and nonobese adolescents","volume":"127","author":"Molnar","year":"1995","unstructured":"Molnar DJeges SErhardt ESchutz Y. Measured and predicted resting metabolic-rate in obese and nonobese adolescents. Journal of Pediatrics1995127571\u2013577. (https:\/\/doi.org\/10.1016\/s0022-3476(9570114-1)10.1016\/S0022-3476(95)70114-1"},{"key":"bib44","series-title":"American Journal of Clinical Nutrition","first-page":"1379","article-title":"World Health Organization equations have shortcomings for predicting resting energy expenditure in persons from a modern, affluent population: generation of a new reference standard from a retrospective analysis of a German database of resting energy expenditure","volume":"80","author":"Muller","year":"2004","unstructured":"Muller MJBosy-Westphal AKlaus SKreymann GLuhrmann PMNeuhauser-Berthold MNoack RPirke KMPlatte PSelberg OWorld Health Organization equations have shortcomings for predicting resting energy expenditure in persons from a modern, affluent population: generation of a new reference standard from a retrospective analysis of a German database of resting energy expenditure. American Journal of Clinical Nutrition2004801379\u20131390. (https:\/\/doi.org\/10.1093\/ajcn\/80.5.1379)"},{"key":"bib45","series-title":"Acta Paediatrica","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1111\/j.1651-2227.2004.tb01000.x","article-title":"Resting energy expenditure in obese children aged 4 to 15 years: measured versus predicted data","volume":"93","author":"Schmelzle","year":"2004","unstructured":"Schmelzle HSchroder CArmbrust SUnverzagt SFusch C. Resting energy expenditure in obese children aged 4 to 15 years: measured versus predicted data. Acta Paediatrica200493739\u2013746. (https:\/\/doi.org\/10.1111\/j.1651-2227.2004.tb01000.x)10.1111\/j.1651-2227.2004.tb01000.x"},{"key":"bib46","series-title":"Journal of Neurosurgery","doi-asserted-by":"publisher","first-page":"73","DOI":"10.3171\/jns.1996.85.1.0073","article-title":"Management of childhood craniopharyngioma: can the morbidity of radical surgery be predicted?","volume":"85","author":"De Vile","year":"1996","unstructured":"De Vile CJGrant DBKendall BENeville BGStanhope RWatkins KEHayward RD. Management of childhood craniopharyngioma: can the morbidity of radical surgery be predicted?Journal of Neurosurgery19968573\u201381. (https:\/\/doi.org\/10.3171\/jns.1996.85.1.0073)10.3171\/jns.1996.85.1.0073"},{"key":"bib47","series-title":"Endocrine","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1007\/s12020-015-0683-x","article-title":"Magnetic resonance imaging as predictor of functional outcome in craniopharyngiomas","volume":"51","author":"Mortini","year":"2016","unstructured":"Mortini PGagliardi FBailo MSpina AParlangeli AFalini ALosa M. Magnetic resonance imaging as predictor of functional outcome in craniopharyngiomas. Endocrine201651148\u2013162. (https:\/\/doi.org\/10.1007\/s12020-015-0683-x)10.1007\/s12020-015-0683-x"},{"key":"bib48","series-title":"Advances in Nutrition","doi-asserted-by":"publisher","first-page":"476","DOI":"10.3945\/an.115.008755","article-title":"Is obesity associated with altered energy expenditure?","volume":"7","author":"Carneiro","year":"2016","unstructured":"Carneiro IPElliott SASiervo MPadwal RBertoli SBattezzati APrado CM. Is obesity associated with altered energy expenditure?Advances in Nutrition20167476\u2013487. (https:\/\/doi.org\/10.3945\/an.115.008755)10.3945\/an.115.008755"},{"key":"bib49","series-title":"Archivos Argentinos de Pediatria","first-page":"43","article-title":"Nutritional assessment of a population with a history of childhood craniopharyngioma seen at Hospital \u2018Prof. Dr. Juan P. Garrahan\u2019","volume":"115","author":"Caminiti","year":"2017","unstructured":"Caminiti CSaure CBomer IBrea MGonzalez Ramos J. Nutritional assessment of a population with a history of childhood craniopharyngioma seen at Hospital \u2018Prof. Dr. Juan P. Garrahan\u2019. Archivos Argentinos de Pediatria201711543\u201349. (https:\/\/doi.org\/10.5546\/aap.2017.eng.43)"},{"key":"bib50","series-title":"Child\u2019s Nervous System","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1007\/s00381-009-1078-1","article-title":"Energy expenditure in obesity associated with craniopharyngioma","volume":"26","author":"Kim","year":"2010","unstructured":"Kim RJShah RTershakovec AMZemel BSSutton LNGrimberg AMoshang T. Energy expenditure in obesity associated with craniopharyngioma. Child\u2019s Nervous System201026913\u2013917. (https:\/\/doi.org\/10.1007\/s00381-009-1078-1)10.1007\/s00381-009-1078-1"},{"key":"bib51","series-title":"Clinical Endocrinology","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1111\/j.1365-2265.2009.03639.x","article-title":"Insulin sensitivity and secretion in children and adolescents with hypothalamic obesity following treatment for craniopharyngioma","volume":"72","author":"Simoneau-Roy","year":"2010","unstructured":"Simoneau-Roy JO'Gorman CPencharz PAdeli KDaneman DHamilton J. Insulin sensitivity and secretion in children and adolescents with hypothalamic obesity following treatment for craniopharyngioma. Clinical Endocrinology201072364\u2013370. (https:\/\/doi.org\/10.1111\/j.1365-2265.2009.03639.x)10.1111\/j.1365-2265.2009.03639.x"},{"key":"bib52","series-title":"European Journal of Endocrinology","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1530\/EJE-12-1082","article-title":"Autonomic nervous system balance in children and adolescents with craniopharyngioma and hypothalamic obesity","volume":"168","author":"Cohen","year":"2013","unstructured":"Cohen MSyme CMcCrindle BWHamilton J. Autonomic nervous system balance in children and adolescents with craniopharyngioma and hypothalamic obesity. European Journal of Endocrinology2013168845\u2013852. (https:\/\/doi.org\/10.1530\/EJE-12-1082)10.1530\/EJE-12-1082"},{"key":"bib53","series-title":"Obesity","doi-asserted-by":"publisher","first-page":"1226","DOI":"10.1002\/oby.21067","article-title":"Semiquantitative analysis of hypothalamic damage on MRI predicts risk for hypothalamic obesity","volume":"23","author":"Roth","year":"2015","unstructured":"Roth CLEslamy HWerny DElfers CShaffer MLPihoker COjemann JDobyns WB. Semiquantitative analysis of hypothalamic damage on MRI predicts risk for hypothalamic obesity. Obesity2015231226\u20131233. (https:\/\/doi.org\/10.1002\/oby.21067)10.1002\/oby.21067"},{"key":"bib54","series-title":"Diabetes, Obesity and Metabolism","doi-asserted-by":"publisher","first-page":"1532","DOI":"10.1111\/dom.14366","article-title":"MRI measures of hypothalamic injury are associated with glucagon-like peptide-1 receptor agonist treatment response in people with hypothalamic obesity","volume":"23","author":"Perez","year":"2021","unstructured":"Perez FAElfers CYanovski JAShoemaker AHAbuzzahab MJRoth CL. MRI measures of hypothalamic injury are associated with glucagon-like peptide-1 receptor agonist treatment response in people with hypothalamic obesity. Diabetes, Obesity and Metabolism2021231532\u20131541. (https:\/\/doi.org\/10.1111\/dom.14366)10.1111\/dom.14366"},{"key":"bib55","series-title":"Frontiers in Endocrinology","doi-asserted-by":"publisher","first-page":"763523","DOI":"10.3389\/fendo.2021.763523","article-title":"Clinical implication of individually tailored segmentation method for distorted hypothalamus in craniopharyngioma","volume":"12","author":"Hong","year":"2021","unstructured":"Hong ARLee MLee JHKim JHKim YHChoi HJ. Clinical implication of individually tailored segmentation method for distorted hypothalamus in craniopharyngioma. Frontiers in Endocrinology202112763523. (https:\/\/doi.org\/10.3389\/fendo.2021.763523)10.3389\/fendo.2021.763523"},{"key":"bib56","series-title":"International Journal of Obesity","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1038\/s41366-018-0185-z","article-title":"Detailed assessment of hypothalamic damage in craniopharyngioma patients with obesity","volume":"43","author":"Fjalldal","year":"2019","unstructured":"Fjalldal SFollin CGabery SSundgren PCBjorkman-Burtscher IMLatt JMannfolk PNordstrom CHRylander LEkman BDetailed assessment of hypothalamic damage in craniopharyngioma patients with obesity. International Journal of Obesity201943533\u2013544. (https:\/\/doi.org\/10.1038\/s41366-018-0185-z)10.1038\/s41366-018-0185-z"},{"key":"bib57","series-title":"Neuropsychobiology","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1159\/000118545","article-title":"Abnormal food-seeking behavior after surgery for craniopharyngioma","volume":"21","author":"Skorzewska","year":"1989","unstructured":"Skorzewska ALal SWaserman JGuyda H. Abnormal food-seeking behavior after surgery for craniopharyngioma. Neuropsychobiology19892117\u201320. (https:\/\/doi.org\/10.1159\/000118545)10.1159\/000118545"},{"key":"bib58","series-title":"Obesity","doi-asserted-by":"publisher","first-page":"1768","DOI":"10.1038\/oby.2009.491","article-title":"Evaluation of a comprehensive care clinic model for children with brain tumor and risk for hypothalamic obesity","volume":"18","author":"Rakhshani","year":"2010","unstructured":"Rakhshani NJeffery ASSchulte FBarrera MAtenafu EGHamilton JK. Evaluation of a comprehensive care clinic model for children with brain tumor and risk for hypothalamic obesity. Obesity2010181768\u20131774. (https:\/\/doi.org\/10.1038\/oby.2009.491)10.1038\/oby.2009.491"},{"key":"bib59","series-title":"European Journal of Endocrinology","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1530\/EJE-12-0792","article-title":"Hypothalamic obesity: prevalence, associations and longitudinal trends in weight in a specialist adult neuroendocrine clinic","volume":"168","author":"Steele","year":"2013","unstructured":"Steele CACuthbertson DJMacFarlane IAJavadpour MDas KSVGilkes CWilding JPDaousi C. Hypothalamic obesity: prevalence, associations and longitudinal trends in weight in a specialist adult neuroendocrine clinic. European Journal of Endocrinology2013168501\u2013507. (https:\/\/doi.org\/10.1530\/EJE-12-0792)10.1530\/EJE-12-0792"},{"key":"bib60","series-title":"Klinische Padiatrie","first-page":"344","article-title":"Childhood craniopharyngioma with hypothalamic obesity \u2013 no long-term weight reduction due to rehabilitation programs","volume":"226","author":"Sterkenburg","year":"2014","unstructured":"Sterkenburg ASHoffmann AGebhardt UWaldeck ESpringer SMuller HL. Childhood craniopharyngioma with hypothalamic obesity \u2013 no long-term weight reduction due to rehabilitation programs. Klinische Padiatrie2014226344\u2013350. (https:\/\/doi.org\/10.1055\/s-0034-1387747)"},{"key":"bib61","series-title":"Journal of Pediatric Endocrinology and Metabolism","first-page":"59","article-title":"Hypothalamic obesity after treatment for craniopharyngioma: the importance of the home environment","volume":"28","author":"Meijneke","year":"2015","unstructured":"Meijneke RWHSchouten-van Meeteren AYNde Boer NYVan Zundert Svan Trotsenburg PASStoelinga Fvan Santen HM. Hypothalamic obesity after treatment for craniopharyngioma: the importance of the home environment. Journal of Pediatric Endocrinology and Metabolism20152859\u201363. (https:\/\/doi.org\/10.1515\/jpem-2014-0338)"},{"key":"bib62","series-title":"Journal of Clinical Endocrinology and Metabolism","doi-asserted-by":"publisher","first-page":"5435","DOI":"10.1210\/jc.2004-0667","article-title":"Changes in height, weight, and body mass index in children with craniopharyngioma after three years of growth hormone therapy: analysis of KIGS (Pfizer International Growth Database)","volume":"89","author":"Geffner","year":"2004","unstructured":"Geffner MLundberg MKoltowska-Haggstrom MAbs RVerhelst JErfurth EMKendall-Taylor PPrice DAJonsson PBakker B. Changes in height, weight, and body mass index in children with craniopharyngioma after three years of growth hormone therapy: analysis of KIGS (Pfizer International Growth Database). Journal of Clinical Endocrinology and Metabolism2004895435\u20135440. (https:\/\/doi.org\/10.1210\/jc.2004-0667)10.1210\/jc.2004-0667"},{"key":"bib63","series-title":"Journal of Human Nutrition and Dietetics","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1111\/jhn.12735","article-title":"A systematic review and quantitative analysis of resting energy expenditure prediction equations in healthy overweight and obese children and adolescents","volume":"33","author":"Chima","year":"2020","unstructured":"Chima LMulrooney HMWarren JMadden AM. A systematic review and quantitative analysis of resting energy expenditure prediction equations in healthy overweight and obese children and adolescents. Journal of Human Nutrition and Dietetics202033373\u2013385. (https:\/\/doi.org\/10.1111\/jhn.12735)10.1111\/jhn.12735"}],"container-title":["Endocrine Connections"],"original-title":[],"link":[{"URL":"https:\/\/ec.bioscientifica.com\/view\/journals\/ec\/11\/8\/EC-22-0276.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ec.bioscientifica.com\/downloadpdf\/journals\/ec\/11\/8\/EC-22-0276.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/ec.bioscientifica.com\/downloadpdf\/journals\/ec\/11\/8\/EC-22-0276.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:45:48Z","timestamp":1784555148000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.bioscientifica.com\/ec\/article\/1040"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,1]]},"references-count":63,"journal-issue":{"issue":"8"},"URL":"https:\/\/doi.org\/10.1530\/ec-22-0276","relation":{},"ISSN":["2049-3614"],"issn-type":[{"value":"2049-3614","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,1]]}}}