{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:57:56Z","timestamp":1791896276817,"version":"4.3.4"},"reference-count":40,"publisher":"Bioscientifica","issue":"9","license":[{"start":{"date-parts":[[2023,7,4]],"date-time":"2023-07-04T00:00:00Z","timestamp":1688428800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["ec.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,8,2]]},"abstract":"<jats:p>\n                    Vitamin D deficiency is associated with hyperlipidemia, but it remains unclear whether vitamin D supplementation reduces serum lipid levels. The aims of this study were to investigate the associations between increased serum 25-hydroxyvitamin D (25(OH)D) concentrations and lipid levels and identify the characteristics of people with or without lipid reduction associated with increased 25(OH)D levels. The medical records of 118 individuals (53 men; mean age, 54.4 \u00b1 10.6 years) whose serum 25(OH)D levels increased between 2 consecutive measurements were retrospectively reviewed. People with increased 25(OH)D levels (from 22.7 (17.6\u201329.2) to 32.1 (25.6\u201336.8) mg\/dL;\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.01) had a significant reduction in serum levels of triglycerides (TGs) (from 111.0 (80\u2013164) to 104.5 (73\u2013142) mg\/dL;\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.01) and total cholesterol (TC) (from 187.5 (155\u2013213) to 181.0 (150\u2013210) mg\/dL;\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.05). The individuals who responded to vitamin D (\u226510% reduction in TG or TC levels) exhibited significantly higher baseline TG and TC levels than those who did not. Only patients with hyperlipidemia (not those without hyperlipidemia) at baseline exhibited significantly reduced TG and TC levels at follow-up. However, increasing serum 25(OH)D concentrations were significantly correlated with decreasing lipid levels in individuals with baseline 25(OH)D levels less than 30 ng\/mL and in individuals aged 50\u201365 years (not in patients younger than 50 years or older than 65 years). In conclusion, increasing serum 25(OH)D concentrations may be potentially helpful for the treatment of hyperlipidemia in people with vitamin D deficiency.\n                  <\/jats:p>","DOI":"10.1530\/ec-23-0013","type":"journal-article","created":{"date-parts":[[2023,7,6]],"date-time":"2023-07-06T10:48:58Z","timestamp":1688640538000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-10","source":"Crossref","is-referenced-by-count":8,"title":["Vitamin D level regulates serum lipids discrepantly in adults with and without dyslipidemia"],"prefix":"10.1530","volume":"12","author":[{"given":"Ying-Lien","family":"Cheng","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting-I","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan"},{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Mei","family":"Chien","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7058-2868","authenticated-orcid":true,"given":"Ting-Wei","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan"},{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Jen","family":"Chen","sequence":"additional","affiliation":[{"name":"Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan"},{"name":"Cardiovascular Research Center, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan"},{"name":"Taipei Heart Institute, Taipei Medical University, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"bib1","series-title":"European Journal of Clinical Nutrition","first-page":"986","article-title":"Vitamin D: the light side of sunshine","volume":"65","author":"Mason","year":"2011","unstructured":"Mason RSSequeira VB & Gordon-Thomson C. 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