{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:17:30Z","timestamp":1784557050919,"version":"3.55.0"},"reference-count":48,"publisher":"Bioscientifica","issue":"11","license":[{"start":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T00:00:00Z","timestamp":1692748800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["ec.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,8,23]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The diagnosis of the polyuria\u2013polydipsia syndrome is challenging. Copeptin is a robust biomarker of arginine vasopressin (AVP) secretion. Arginine, which stimulates growth hormone (GH), has been shown also to stimulate copeptin secretion via unknown mechanisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>The aim was to investigate copeptin levels in response to three different GH stimulation tests in patients suspected of GH deficiency.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this cross-sectional study, we measured plasma copeptin levels at baseline and at 60, 105, and 150 min in patients undergoing a stimulation test for growth hormone deficiency with either arginine (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200916), clonidine (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20098) or the insulin tolerance test (ITT) (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200910).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In patients undergoing the arginine test, the mean age was 9 years, and 10 years for clonidine. The ITT was only performed in adult patients (&gt;18 years) with a mean age of 49 years. Copeptin level increased significantly from baseline to 60 min after arginine (\n                      <jats:italic>P &lt;<\/jats:italic>\n                      0.01) and ITT (\n                      <jats:italic>P &lt;<\/jats:italic>\n                      0.01). By contrast, copeptin level tended to decrease after clonidine stimulation (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.14).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These data support that infusion of arginine increases plasma copeptin levels and reveal a comparable response after an ITT. We hypothesize that the underlying mechanism is abrogation of somatostatin-induced AVP suppression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1530\/ec-23-0042","type":"journal-article","created":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T07:02:42Z","timestamp":1692774162000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-10","source":"Crossref","is-referenced-by-count":8,"title":["Copeptin levels increase in response to both insulin-induced hypoglycemia and arginine but not to clonidine: data from GH-stimulation tests"],"prefix":"10.1530","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4477-8370","authenticated-orcid":true,"given":"Jelena","family":"Stankovic","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurt","family":"Kristensen","sequence":"additional","affiliation":[{"name":"Steno Diabetes Center Aarhus (SDCA), Aarhus University Hospital, Aarhus, Denmark"},{"name":"Department of Pediatrics, Aarhus University Hospital, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels","family":"Birkeb\u00e6k","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Aarhus University Hospital, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7408-1526","authenticated-orcid":true,"given":"Jens Otto Lunde","family":"J\u00f8rgensen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8041-6994","authenticated-orcid":true,"given":"Esben","family":"S\u00f8ndergaard","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark"},{"name":"Steno Diabetes Center Aarhus (SDCA), Aarhus University Hospital, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"bib1","series-title":"New England Journal of Medicine","first-page":"428","article-title":"A copeptin-based approach in the diagnosis of diabetes insipidus","volume":"379","author":"Fenske","year":"2018","unstructured":"Fenske WRefardt JChifu ISchnyder IWinzeler BDrummond JRibeiro-Oliveira AJrDrescher TBilz SVogt DR, A copeptin-based approach in the diagnosis of diabetes insipidus. New England Journal of Medicine2018379428\u2013439. (https:\/\/doi.org\/10.1056\/NEJMoa1803760)"},{"key":"bib2","series-title":"Best Practice and Research. Clinical Endocrinology and Metabolism","first-page":"101398","article-title":"Diagnosis and differential diagnosis of diabetes insipidus: update","volume":"34","author":"Refardt","year":"2020","unstructured":"Refardt J. Diagnosis and differential diagnosis of diabetes insipidus: update. Best Practice and Research. Clinical Endocrinology and Metabolism202034101398. (https:\/\/doi.org\/10.1016\/j.beem.2020.101398)"},{"key":"bib3","series-title":"New England Journal of Medicine","first-page":"1539","article-title":"A comparison of plasma vasopressin measurements with a standard indirect test in the differential diagnosis of polyuria","volume":"305","author":"Zerbe","year":"1981","unstructured":"Zerbe RL & Robertson GL. A comparison of plasma vasopressin measurements with a standard indirect test in the differential diagnosis of polyuria. New England Journal of Medicine19813051539\u20131546. (https:\/\/doi.org\/10.1056\/NEJM198112243052601)"},{"key":"bib4","series-title":"Journal of Clinical Investigation","first-page":"2340","article-title":"Development and clinical application of a new method for the radioimmunoassay of arginine vasopressin in human plasma","volume":"52","author":"Robertson","year":"1973","unstructured":"Robertson GLMahr EAAthar S & Sinha T. Development and clinical application of a new method for the radioimmunoassay of arginine vasopressin in human plasma. Journal of Clinical Investigation1973522340\u20132352. (https:\/\/doi.org\/10.1172\/JCI107423)"},{"key":"bib5","series-title":"Reviews in Endocrine and Metabolic Disorders","first-page":"283","article-title":"Vasopressin and copeptin in health and disease","volume":"20","author":"Christ-Crain","year":"2019","unstructured":"Christ-Crain M. Vasopressin and copeptin in health and disease. Reviews in Endocrine and Metabolic Disorders201920283\u2013294. (https:\/\/doi.org\/10.1007\/s11154-019-09509-9)"},{"key":"bib6","series-title":"Clinical Endocrinology","first-page":"763","article-title":"Arginine potentiates the GHRH- but not the pyridostigmine-induced GH secretion in normal short children. Further evidence for a somatostatin suppressing effect of arginine","volume":"32","author":"Ghigo","year":"1990","unstructured":"Ghigo EBellone JMazza EImperiale EProcopio MValente FLala RDe Sanctis C & Camanni F. Arginine potentiates the GHRH- but not the pyridostigmine-induced GH secretion in normal short children. Further evidence for a somatostatin suppressing effect of arginine. Clinical Endocrinology199032763\u2013767. (https:\/\/doi.org\/10.1111\/j.1365-2265.1990.tb00923.x)"},{"key":"bib7","series-title":"Best Practice and Research. Clinical Endocrinology and Metabolism","first-page":"101440","article-title":"Central diabetes insipidus in children: diagnosis and management","volume":"34","author":"Patti","year":"2020","unstructured":"Patti GIbba AMorana GNapoli FFava Ddi Iorgi N & Maghnie M. Central diabetes insipidus in children: diagnosis and management. Best Practice and Research. Clinical Endocrinology and Metabolism202034101440. (https:\/\/doi.org\/10.1016\/j.beem.2020.101440)"},{"key":"bib8","series-title":"Lancet","first-page":"587","article-title":"Arginine-stimulated copeptin measurements in the differential diagnosis of diabetes insipidus: a prospective diagnostic study","volume":"394","author":"Winzeler","year":"2019","unstructured":"Winzeler BCesana-Nigro NRefardt JVogt DRImber CMorin BPopovic MSteinmetz MSailer COSzinnai G, Arginine-stimulated copeptin measurements in the differential diagnosis of diabetes insipidus: a prospective diagnostic study. Lancet2019394587\u2013595. (https:\/\/doi.org\/10.1016\/S0140-6736(1931255-3)"},{"key":"bib9","series-title":"Scientific Reports","first-page":"10104","article-title":"Validity of different copeptin assays in the differential diagnosis of the polyuria-polydipsia syndrome","volume":"11","author":"Sailer","year":"2021","unstructured":"Sailer CORefardt JBlum CASchnyder IMolina-Tijeras JAFenske W & Christ-Crain M. Validity of different copeptin assays in the differential diagnosis of the polyuria-polydipsia syndrome. Scientific Reports20211110104. (https:\/\/doi.org\/10.1038\/s41598-021-89505-9)"},{"key":"bib10","series-title":"Pituitary","first-page":"636","article-title":"The effect of glucose dynamics on plasma copeptin levels upon glucagon, arginine, and macimorelin stimulation in healthy adults: data from: Glucacop, Macicop, and CARGO study","volume":"25","author":"Atila","year":"2022","unstructured":"Atila CMonnerat SUrwyler SARefardt JWinzeler B & Christ-Crain M. The effect of glucose dynamics on plasma copeptin levels upon glucagon, arginine, and macimorelin stimulation in healthy adults: data from: Glucacop, Macicop, and CARGO study. Pituitary202225636\u2013644. (https:\/\/doi.org\/10.1007\/s11102-022-01240-0)"},{"key":"bib11","series-title":"Journal of Clinical Endocrinology and Metabolism","first-page":"1186","article-title":"Arginine stimulates growth hormone secretion by suppressing endogenous somatostatin secretion","volume":"67","author":"Alba-Roth","year":"1988","unstructured":"Alba-Roth JM\u00fcller OASchopohl J & von Werder K. Arginine stimulates growth hormone secretion by suppressing endogenous somatostatin secretion. Journal of Clinical Endocrinology and Metabolism1988671186\u20131189. (https:\/\/doi.org\/10.1210\/jcem-67-6-1186)"},{"key":"bib12","series-title":"Endocrine Practice","first-page":"1191","article-title":"American Association of Clinical Endocrinologists and American College of Endocrinology guidelines for management of growth hormone deficiency in adults and patients transitioning from pediatric to adult care","volume":"25","author":"Yuen","year":"2019","unstructured":"Yuen KCJBiller BMKRadovick SCarmichael JDJasim SPantalone KM & Hoffman AR. American Association of Clinical Endocrinologists and American College of Endocrinology guidelines for management of growth hormone deficiency in adults and patients transitioning from pediatric to adult care. Endocrine Practice2019251191\u20131232. (https:\/\/doi.org\/10.4158\/GL-2019-0405)"},{"key":"bib13","series-title":"Journal of Clinical Endocrinology and Metabolism","first-page":"2640","article-title":"Anterior and posterior pituitary function testing with simultaneous insulin tolerance test and a novel copeptin assay","volume":"92","author":"Katan","year":"2007","unstructured":"Katan MMorgenthaler NGDixit KCRutishauser JBrabant GEM\u00fcller B & Christ-Crain M. Anterior and posterior pituitary function testing with simultaneous insulin tolerance test and a novel copeptin assay. Journal of Clinical Endocrinology and Metabolism2007922640\u20132643. (https:\/\/doi.org\/10.1210\/jc.2006-2046)"},{"key":"bib14","series-title":"Neuroendocrinology","first-page":"244","article-title":"Growth hormone response to oral glucose load: from normal to pathological conditions","volume":"108","author":"Hage","year":"2019","unstructured":"Hage MKamenick\u00fd P & Chanson P. Growth hormone response to oral glucose load: from normal to pathological conditions. Neuroendocrinology2019108244\u2013255. (https:\/\/doi.org\/10.1159\/000497214)"},{"key":"bib15","series-title":"Journal of Clinical Endocrinology and Metabolism","first-page":"1581","article-title":"Alpha 2-adrenergic agonism enhances the growth hormone (GH) response to GH-releasing hormone through an inhibition of hypothalamic somatostatin release in normal men","volume":"71","author":"Devesa","year":"1990","unstructured":"Devesa JArce VLois NTresguerres JA & Lima L. Alpha 2-adrenergic agonism enhances the growth hormone (GH) response to GH-releasing hormone through an inhibition of hypothalamic somatostatin release in normal men. Journal of Clinical Endocrinology and Metabolism1990711581\u20131588. (https:\/\/doi.org\/10.1210\/jcem-71-6-1581)"},{"key":"bib16","series-title":"Psychiatry Research","first-page":"311","article-title":"Dose-response profiles of plasma growth hormone and vasopressin after clonidine challenge in man","volume":"31","author":"Brown","year":"1990","unstructured":"Brown GMMazurek MAllen DSzechtman B & Cleghorn JM. Dose-response profiles of plasma growth hormone and vasopressin after clonidine challenge in man. Psychiatry Research199031311\u2013320. (https:\/\/doi.org\/10.1016\/0165-1781(9090100-j)"},{"key":"bib17","series-title":"Clinical Endocrinology","first-page":"548","article-title":"Arginine-stimulated copeptin in children and adolescents","volume":"98","author":"Binder","year":"2023","unstructured":"Binder GWeber KPeter A & Schweizer R. Arginine-stimulated copeptin in children and adolescents. Clinical Endocrinology202398548\u2013553. (https:\/\/doi.org\/10.1111\/cen.14880)"},{"key":"bib18","series-title":"Frontiers of Hormone Research","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1159\/000318503","article-title":"Testing growth hormone deficiency in adults","volume":"38","author":"Gabellieri","year":"2010","unstructured":"Gabellieri EChiovato LLage MCastro AI & Casanueva FF. Testing growth hormone deficiency in adults. Frontiers of Hormone Research201038139\u2013144. (https:\/\/doi.org\/10.1159\/000318503)"},{"key":"bib19","series-title":"Growth Hormone and IGF Research","first-page":"69","article-title":"L-arginine-induced growth hormone secretion is not influenced by co-infusion of the nitric oxide synthase inhibitor N-monomethyl-L-arginine in healthy men","volume":"9","author":"Fisker","year":"1999","unstructured":"Fisker SNielsen SEbdrup LBech JNChristiansen JSPedersen EB & J\u00f8rgensen JO. L-arginine-induced growth hormone secretion is not influenced by co-infusion of the nitric oxide synthase inhibitor N-monomethyl-L-arginine in healthy men. Growth Hormone and IGF Research1999969\u201373. (https:\/\/doi.org\/10.1054\/ghir.1999.0089)"},{"key":"bib20","series-title":"Neuroimmunomodulation","first-page":"195","article-title":"Role of nitric oxide in control of growth hormone release in the rat","volume":"1","author":"Rettori","year":"1994","unstructured":"Rettori VBelova NYu WHGimeno M & McCann SM. Role of nitric oxide in control of growth hormone release in the rat. Neuroimmunomodulation19941195\u2013200. (https:\/\/doi.org\/10.1159\/000097160)"},{"key":"bib21","series-title":"Neuroendocrinology","first-page":"955","article-title":"Evidence that nitric oxide can act centrally to stimulate vasopressin release","volume":"57","author":"Ota","year":"1993","unstructured":"Ota MCrofton JTFestavan GT & Share L. Evidence that nitric oxide can act centrally to stimulate vasopressin release. Neuroendocrinology199357955\u2013959. (https:\/\/doi.org\/10.1159\/000126459)"},{"key":"bib22","series-title":"American Journal of Physiology","first-page":"H822","article-title":"Effect of inhibition of nitric oxide synthesis on vasopressin secretion in conscious rabbits","volume":"266","author":"Goyer","year":"1994","unstructured":"Goyer MBui HChou LEvans JKeil LC & Reid IA. Effect of inhibition of nitric oxide synthesis on vasopressin secretion in conscious rabbits. American Journal of Physiology1994266H822\u2013H828. (https:\/\/doi.org\/10.1152\/ajpheart.1994.266.2.H822)"},{"key":"bib23","series-title":"Hypertension","first-page":"951","article-title":"Mechanisms involved in the cardiovascular-renal actions of nitric oxide inhibition","volume":"23","author":"Manning","year":"1994","unstructured":"Manning RDJrHu L & Williamson TD. Mechanisms involved in the cardiovascular-renal actions of nitric oxide inhibition. Hypertension: Tex199423951\u2013956. (https:\/\/doi.org\/10.1161\/01.hyp.23.6.951)"},{"key":"bib24","series-title":"Frontiers in Neuroendocrinology","first-page":"351","article-title":"Role of nitric oxide in the regulation of renin and vasopressin secretion","volume":"15","author":"Reid","year":"1994","unstructured":"Reid IA. Role of nitric oxide in the regulation of renin and vasopressin secretion. Frontiers in Neuroendocrinology199415351\u2013383. (https:\/\/doi.org\/10.1006\/frne.1994.1014)"},{"key":"bib25","series-title":"European Journal of Endocrinology","first-page":"543","article-title":"L-arginine is unlikely to exert neuroendocrine effects in humans via the generation of nitric oxide","volume":"135","author":"Korbonits","year":"1996","unstructured":"Korbonits MTrainer PJFanciulli GOliva OPala ADettori ABesser MDelitala G & Grossman AB. L-arginine is unlikely to exert neuroendocrine effects in humans via the generation of nitric oxide. European Journal of Endocrinology1996135543\u2013547. (https:\/\/doi.org\/10.1530\/eje.0.1350543)"},{"key":"bib26","series-title":"Neuroendocrinology","first-page":"291","article-title":"Arginine reinstates the somatotrope responsiveness to intermittent growth hormone-releasing hormone administration in normal adults","volume":"54","author":"Ghigo","year":"1991","unstructured":"Ghigo EArvat EValente FNicolosi MBoffano GMProcopio MBellone JMaccario MMazza E & Camanni F. Arginine reinstates the somatotrope responsiveness to intermittent growth hormone-releasing hormone administration in normal adults. Neuroendocrinology199154291\u2013294. (https:\/\/doi.org\/10.1159\/000125890)"},{"key":"bib27","series-title":"Brain Research","first-page":"199","article-title":"Somatostatin centrally inhibits vasopressin secretion during haemorrhage","volume":"436","author":"Wang","year":"1987","unstructured":"Wang XMTresham JJCongiu MCoghlan JP & Scoggins BA. Somatostatin centrally inhibits vasopressin secretion during haemorrhage. Brain Research1987436199\u2013203. (https:\/\/doi.org\/10.1016\/0006-8993(8791577-0)"},{"key":"bib28","series-title":"Annals of the New York Academy of Sciences","first-page":"142","article-title":"Somatostatin is decreased in the neurohypophysis of the Brattleboro rat and may play a role in the regulation of vasopressin secretion","volume":"394","author":"G\u00fcllner","year":"1982","unstructured":"G\u00fcllner HGKulakowski EC & Unger RH. Somatostatin is decreased in the neurohypophysis of the Brattleboro rat and may play a role in the regulation of vasopressin secretion. Annals of the New York Academy of Sciences1982394142\u2013146. (https:\/\/doi.org\/10.1111\/j.1749-6632.1982.tb37420.x)"},{"key":"bib29","series-title":"Kidney International Reports","first-page":"1170","article-title":"Effect of a somatostatin analogue on the vasopressin pathway in patients with ADPKD","volume":"4","author":"Messchendorp","year":"2019","unstructured":"Messchendorp ALKramers BJSpithoven EMStade KMeijer EGansevoort RT & DIPAK-1 Study Investigators. Effect of a somatostatin analogue on the vasopressin pathway in patients with ADPKD. Kidney International Reports201941170\u20131174. (https:\/\/doi.org\/10.1016\/j.ekir.2019.04.027)"},{"key":"bib30","series-title":"European Journal of Endocrinology","first-page":"737","article-title":"Copeptin concentrations during psychological stress: the PsyCo study","volume":"171","author":"Siegenthaler","year":"2014","unstructured":"Siegenthaler JWalti CUrwyler SASchuetz P & Christ-Crain M. Copeptin concentrations during psychological stress: the PsyCo study. European Journal of Endocrinology2014171737\u2013742. (https:\/\/doi.org\/10.1530\/EJE-14-0405)"},{"key":"bib31","series-title":"Journal of Clinical Endocrinology and Metabolism","first-page":"935","article-title":"Arginine vasopressin response to insulin-induced hypoglycemia in man","volume":"53","author":"Baylis","year":"1981","unstructured":"Baylis PHZerbe RL & Robertson GL. Arginine vasopressin response to insulin-induced hypoglycemia in man. Journal of Clinical Endocrinology and Metabolism198153935\u2013940. (https:\/\/doi.org\/10.1210\/jcem-53-5-935)"},{"key":"bib32","series-title":"Clinical Endocrinology","first-page":"179","article-title":"Plasma oxytocin, arginine vasopressin and atrial natriuretic peptide responses to insulin-induced hypoglycaemia in man","volume":"26","author":"Fisher","year":"1987","unstructured":"Fisher BMBaylis PH & Frier BM. Plasma oxytocin, arginine vasopressin and atrial natriuretic peptide responses to insulin-induced hypoglycaemia in man. Clinical Endocrinology198726179\u2013185. (https:\/\/doi.org\/10.1111\/j.1365-2265.1987.tb00775.x)"},{"key":"bib33","series-title":"Pituitary","first-page":"681","article-title":"Copeptin response to hypoglycemic stress is linked to prolactin activation in children","volume":"23","author":"Drummond","year":"2020","unstructured":"Drummond JBSoares BSPedrosa WVieira ELMTeixeira ALChrist-Crain M & Ribeiro-Oliveira AJr. Copeptin response to hypoglycemic stress is linked to prolactin activation in children. Pituitary202023681\u2013690. (https:\/\/doi.org\/10.1007\/s11102-020-01076-6)"},{"key":"bib34","series-title":"American Journal of Physiology","first-page":"E607","article-title":"Osmoregulation of thirst and vasopressin secretion in human subjects: effect of various solutes","volume":"244","author":"Zerbe","year":"1983","unstructured":"Zerbe RL & Robertson GL. Osmoregulation of thirst and vasopressin secretion in human subjects: effect of various solutes. American Journal of Physiology1983244E607\u2013E614. (https:\/\/doi.org\/10.1152\/ajpendo.1983.244.6.E607)"},{"key":"bib35","series-title":"Neuroendocrinology","first-page":"551","article-title":"Activation of cholinergic neurotransmission by pyridostigmine reverses the inhibitory effect of hyperglycemia on growth hormone (GH) releasing hormone-induced GH secretion in man: does acute hyperglycemia act through hypothalamic release of somatostatin?","volume":"49","author":"Pe\u00f1alva","year":"1989","unstructured":"Pe\u00f1alva ABurguera BCasabiell XTresguerres JADieguez C & Casanueva FF. Activation of cholinergic neurotransmission by pyridostigmine reverses the inhibitory effect of hyperglycemia on growth hormone (GH) releasing hormone-induced GH secretion in man: does acute hyperglycemia act through hypothalamic release of somatostatin?Neuroendocrinology198949551\u2013554. (https:\/\/doi.org\/10.1159\/000125166)"},{"key":"bib36","series-title":"Journal of Endocrinological Investigation","first-page":"349","article-title":"The infusion of somatostatin reduces the arginine-vasopressin response to insulin-induced hypoglycemia in man","volume":"12","author":"Chiodera","year":"1989","unstructured":"Chiodera PGnudi ABianconi LCamellini LRossi GMuzzetto PFagnoni FSchianchi LVolpi R & Coiro V. The infusion of somatostatin reduces the arginine-vasopressin response to insulin-induced hypoglycemia in man. Journal of Endocrinological Investigation198912349\u2013353. (https:\/\/doi.org\/10.1007\/BF03350005)"},{"key":"bib37","series-title":"NeuroReport","first-page":"1822","article-title":"Inhibitory control of nitric oxide on the arginine-vasopressin and oxytocin response to hypoglycaemia in normal men","volume":"5","author":"Chiodera","year":"1994","unstructured":"Chiodera PVolpi R & Coiro V. Inhibitory control of nitric oxide on the arginine-vasopressin and oxytocin response to hypoglycaemia in normal men. NeuroReport199451822\u20131824. (https:\/\/doi.org\/10.1097\/00001756-199409080-00034)"},{"key":"bib38","series-title":"Journal of Cerebral Blood Flow and Metabolism","first-page":"54","article-title":"Examination of potential mechanisms in the enhancement of cerebral blood flow by hypoglycemia and pharmacological doses of deoxyglucose","volume":"17","author":"Horinaka","year":"1997","unstructured":"Horinaka NArtz NJehle JTakahashi SKennedy C & Sokoloff L. Examination of potential mechanisms in the enhancement of cerebral blood flow by hypoglycemia and pharmacological doses of deoxyglucose. Journal of Cerebral Blood Flow and Metabolism19971754\u201363. (https:\/\/doi.org\/10.1097\/00004647-199701000-00008)"},{"key":"bib39","series-title":"Swiss Medical Weekly","first-page":"w13101","article-title":"The stress hormone copeptin: a new prognostic biomarker in acute illness","volume":"140","author":"Katan","year":"2010","unstructured":"Katan M & Christ-Crain M. The stress hormone copeptin: a new prognostic biomarker in acute illness. Swiss Medical Weekly2010140w13101. (https:\/\/doi.org\/10.4414\/smw.2010.13101)"},{"key":"bib40","series-title":"Clinical Endocrinology","first-page":"485","article-title":"Interaction of clonidine and GHRH on GH secretion in vivo and in vitro","volume":"30","author":"Alba-Roth","year":"1989","unstructured":"Alba-Roth JLosa MSpiess YSchopohl JM\u00fcller OA & von Werder K. Interaction of clonidine and GHRH on GH secretion in vivo and in vitro. Clinical Endocrinology198930485\u2013491. (https:\/\/doi.org\/10.1111\/j.1365-2265.1989.tb01419.x)"},{"key":"bib41","series-title":"Neuroendocrinology","first-page":"395","article-title":"Clonidine decreases plasma and cerebrospinal fluid arginine vasopressin but not oxytocin in humans","volume":"46","author":"Peskind","year":"1987","unstructured":"Peskind ERRaskind MALeake RDErvin MGRoss MG & Dorsa DM. Clonidine decreases plasma and cerebrospinal fluid arginine vasopressin but not oxytocin in humans. Neuroendocrinology198746395\u2013400. (https:\/\/doi.org\/10.1159\/000124851)"},{"key":"bib42","series-title":"Brain Research","first-page":"275","article-title":"The organization of noradrenergic pathways from the brainstem to the paraventricular and supraoptic nuclei in the rat","volume":"257","author":"Sawchenko","year":"1982","unstructured":"Sawchenko PE & Swanson LW. The organization of noradrenergic pathways from the brainstem to the paraventricular and supraoptic nuclei in the rat. Brain Research1982257275\u2013325. (https:\/\/doi.org\/10.1016\/0165-0173(8290010-8)"},{"key":"bib43","series-title":"Brain Research","first-page":"192","article-title":"Noradrenergic stimulation of supraoptic neuronal activity and vasopressin release in vitro: mediation by an alpha 1-receptor","volume":"365","author":"Armstrong","year":"1986","unstructured":"Armstrong WEGallagher MJ & Sladek CD. Noradrenergic stimulation of supraoptic neuronal activity and vasopressin release in vitro: mediation by an alpha 1-receptor. Brain Research1986365192\u2013197. (https:\/\/doi.org\/10.1016\/0006-8993(8690739-0)"},{"key":"bib44","series-title":"European Journal of Endocrinology","first-page":"65","article-title":"Glucagon-stimulated copeptin measurements in the differential diagnosis of diabetes insipidus: a double-blind, randomized, placebo-controlled study","volume":"187","author":"Atila","year":"2022","unstructured":"Atila CGaisl OVogt DRWerlen LSzinnai G & Christ-Crain M. Glucagon-stimulated copeptin measurements in the differential diagnosis of diabetes insipidus: a double-blind, randomized, placebo-controlled study. European Journal of Endocrinology202218765\u201374. (https:\/\/doi.org\/10.1530\/EJE-22-0033)"},{"key":"bib45","series-title":"Clinical Endocrinology","first-page":"463","article-title":"An audit of 500 subcutaneous glucagon stimulation tests to assess growth hormone and ACTH secretion in patients with hypothalamic-pituitary disease","volume":"54","author":"Leong","year":"2001","unstructured":"Leong KSWalker ABMartin IWile DWilding J & MacFarlane IA. An audit of 500 subcutaneous glucagon stimulation tests to assess growth hormone and ACTH secretion in patients with hypothalamic-pituitary disease. Clinical Endocrinology200154463\u2013468. (https:\/\/doi.org\/10.1046\/j.1365-2265.2001.01169.x)"},{"key":"bib46","series-title":"Nature Reviews. Endocrinology","first-page":"608","article-title":"Advances in differential diagnosis and management of growth hormone deficiency in children","volume":"17","author":"Hage","year":"2021","unstructured":"Hage CGan HWIbba APatti GDattani MLoche SMaghnie M & Salvatori R. Advances in differential diagnosis and management of growth hormone deficiency in children. Nature Reviews. Endocrinology202117608\u2013624. (https:\/\/doi.org\/10.1038\/s41574-021-00539-5)"},{"key":"bib47","series-title":"Pituitary","first-page":"555","article-title":"Effects of oral macimorelin on copeptin and anterior pituitary hormones in healthy volunteers","volume":"24","author":"Urwyler","year":"2021","unstructured":"Urwyler SALustenberger SDrummond JRSoares BSVogt DRAmmer NYuen KCJRibeiro-Oliveira A & Christ-Crain M. Effects of oral macimorelin on copeptin and anterior pituitary hormones in healthy volunteers. Pituitary202124555\u2013563. (https:\/\/doi.org\/10.1007\/s11102-021-01132-9)"},{"key":"bib48","series-title":"European Journal of Endocrinology","first-page":"23","article-title":"Acute intravenous acyl ghrelin infusion induces thirst but does not affect sodium excretion: two randomized, double-blind, placebo-controlled crossover studies in hypopituitary patients","volume":"181","author":"Vestergaard","year":"2019","unstructured":"Vestergaard ETM\u00f8ller NAndersen RFRittig S & J\u00f8rgensen JOL. Acute intravenous acyl ghrelin infusion induces thirst but does not affect sodium excretion: two randomized, double-blind, placebo-controlled crossover studies in hypopituitary patients. European Journal of Endocrinology201918123\u201330. 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