{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:17:31Z","timestamp":1784557051630,"version":"3.55.0"},"reference-count":20,"publisher":"Bioscientifica","issue":"8","license":[{"start":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T00:00:00Z","timestamp":1686182400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["ec.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,7,26]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Intracranial germ cell tumors frequently arise from the midline of the brain, occasionally presenting as bifocal diseases. The predominant lesion might affect clinical characteristics and neuroendocrine outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>A retrospective cohort study involving 38 patients with intracranial bifocal germ cell tumors was performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result<\/jats:title>\n                    <jats:p>\n                      Twenty-one patients were assigned to the sellar-predominant group, while the other 17 patients were assigned to the non-sellar-predominant group. Differences in gender ratio, age, manifestation, the incidence of metastasis, the incidence of elevated tumor markers, human chorionic gonadotropin levels in serum and in cerebrospinal fluid, diagnostic method, and tumor type were not significant between the sellar-predominant group and the non-sellar-predominant group. Before treatment, the sellar-predominant group had a higher incidence of adenohypophysis hormone deficiencies and central diabetes insipidus than those of the non-sellar-predominant group, without significant differences. After multidisciplinary therapy, the sellar-predominant group also had a higher incidence of adenohypophysis hormone deficiencies and central diabetes insipidus than those of the non-sellar-predominant group. The differences in the hypothalamic\u2013pituitary\u2013adrenal (HPA) axis impairment (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.008), hypothalamic\u2013pituitary\u2013thyroid (HPT) axis impairment (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.048), and hypothalamic\u2013pituitary\u2013gonad (HPG) axis impairment (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.029) were significant between sellar-predominant group and non-sellar-predominant group, while the others were not. At median 6 (3, 43) months of follow-up visit, sellar-predominant group had a higher incidence of adenohypophysis hormone deficiencies than those of non-sellar-predominant group. The differences in the HPA impairment (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.002), HPT impairment (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.024), and HPG impairment (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.000) were significant, while the others were not. Further comparison of the neuroendocrine function between different subtypes of sellar-predominant patients indicated that the differences in adenohypophysis hormone deficiencies and central diabetes insipidus were not significant between the two subtype groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Bifocal patients with different predominant lesions present similar manifestations and neuroendocrine disorders before treatment. Non-sellar-predominant patients would have better neuroendocrine outcomes after tumor treatment. The distinction of the predominant lesion in patients with bifocal intracranial germ cell tumor plays a valuable role in predicting neuroendocrine outcomes, as well as in optimizing long-term neuroendocrine management during survival time.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1530\/ec-23-0168","type":"journal-article","created":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T13:28:16Z","timestamp":1686230896000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-10","source":"Crossref","is-referenced-by-count":2,"title":["Comparison of different predominant lesions in intracranial bifocal germ cell tumors to predict neuroendocrine outcomes"],"prefix":"10.1530","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8722-9144","authenticated-orcid":true,"given":"Dan","family":"Liang","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8795-6544","authenticated-orcid":true,"given":"Han","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2016-0664","authenticated-orcid":true,"given":"Li-Yong","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"bib1","series-title":"International Journal of Andrology","first-page":"256","article-title":"Why human extragonadal germ cell tumours occur in the midline of the body: old concepts, new perspectives","volume":"30","author":"Oosterhuis","year":"2007","unstructured":"Oosterhuis JWStoop HHonecker F & Looijenga LH. 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