{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:17:45Z","timestamp":1784557065077,"version":"3.55.0"},"reference-count":30,"publisher":"Bioscientifica","issue":"5","license":[{"start":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T00:00:00Z","timestamp":1711584000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["ec.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,3,28]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Hashimoto\u2019s thyroiditis is an inflammatory disease, and research suggests that a low-carbohydrate diet may have potential anti-inflammatory effects. This study aims to utilize Dixon-T2-weighted imaging (WI) sequence for a semi-quantitative assessment of the impact of a low-carbohydrate diet on the degree of thyroid inflammation in patients with Hashimoto\u2019s thyroiditis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Forty patients with Hashimoto\u2019s thyroiditis were recruited for this study and randomly divided into two groups: one with a normal diet and the other with a low-carbohydrate diet. Antibodies against thyroid peroxidase (TPOAb) and thyroglobulin (TgAb) were measured for all participants. Additionally, thyroid water content was semi-quantitatively measured using Dixon-T2WI. The same tests and measurements were repeated for all participants after 6 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After 6 months of a low-carbohydrate diet, patients with Hashimoto\u2019s thyroiditis showed a significant reduction in thyroid water content (94.84 \u00b1 1.57% vs 93.07 \u00b1 2.05%,\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.05). Concurrently, a decrease was observed in levels of TPOAb and TgAb (TPOAb: 211.30 (92.63\u2013614.62) vs 89.45 (15.9\u2013215.67); TgAb: 17.05 (1.47\u201381.64) vs 4.1 (0.51\u201319.42),\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.05). In contrast, there were no significant differences in thyroid water content or TPOAb and TgAb levels for patients with Hashimoto\u2019s thyroiditis following a normal diet after 6 months (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Dixon-T2WI can quantitatively assess the degree of thyroid inflammation in patients with Hashimoto\u2019s thyroiditis. Following a low-carbohydrate diet intervention, there is a significant reduction in thyroid water content and a decrease in levels of TPOAb and TgAb. These results suggest that a low-carbohydrate diet may help alleviate inflammation in patients with Hashimoto\u2019s thyroiditis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1530\/ec-23-0477","type":"journal-article","created":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T09:55:40Z","timestamp":1711619740000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-10","source":"Crossref","is-referenced-by-count":5,"title":["MRI quantitative assessment of the effects of low-carbohydrate therapy on Hashimoto\u2019s thyroiditis"],"prefix":"10.1530","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1746-8967","authenticated-orcid":true,"given":"Xiao-Shan","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Radiology, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Dai","sequence":"additional","affiliation":[{"name":"Zhejiang Chinese Medical University, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Xia","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Radiology, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Yi","family":"Xiang","sequence":"additional","affiliation":[{"name":"Department of Radiology, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Zhong","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Radiology, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian-Yu","family":"Ke","sequence":"additional","affiliation":[{"name":"Department of Radiology, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin-Ying","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Radiology, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi-Hao","family":"Shi","sequence":"additional","affiliation":[{"name":"Zhejiang Chinese Medical University, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2050-5789","authenticated-orcid":true,"given":"Shu-Feng","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Radiology, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"bib1","series-title":"Indian Journal of Clinical Biochemistry","first-page":"9","article-title":"Autoimmune thyroid disorders-An update","volume":"20","author":"Swain","year":"2005","unstructured":"Swain MSwain T & Mohanty BK. 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