{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T11:48:11Z","timestamp":1791460091457,"version":"4.3.4"},"reference-count":32,"publisher":"Bioscientifica","issue":"9","license":[{"start":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T00:00:00Z","timestamp":1720137600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["ec.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,7,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Thyroid autoimmunity (TAI) may be present in 1\u201317% of pregnant women. Monitoring of thyroid function in euthyroid pregnant women positive for anti-thyroperoxidase antibodies (TPOAb+) is recommended.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine the prevalence and possible clinical and biological risk factors of biochemical progression (rise in serum thyroid-stimulating hormone (TSH) &gt; 2.5 mU\/L) at second blood sampling during pregnancy, in euthyroid women (TSH \u2264 2.5 mU\/L) according to their TPOAb status.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This study included demographic and biological data from two previously published cohorts (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009274 women from August 1996 to May 1997 Copenhagen cohort, and\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200966 women from January 2013 to December 2014 Brussels cohort) having at least two measurements of TSH and free thyroxine (FT4) and at least one of TPOAb during spontaneously achieved singleton pregnancies.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The majority of women studied did not show biochemical progression. Only 4.2% progressed, significantly more frequently among TPOAb+ women, as compared to TPOAb\u2212 group (9.4 vs 2.7%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.015). No rise in serum TSH &gt; 4 mU\/L at 2nd sampling was observed. Higher baseline TSH levels were associated with biochemical progression in both TPOAb+ (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.05) and TPOAb\u2212 women (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001), whereas maternal age, BMI, multiparity, smoking, FT4, and TPOAb concentrations were not significantly different between women with and without progression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Only a minority of euthyroid women with thyroid autoimmunity presented biochemical progression and none with a TSH &gt; 4 mU\/L. Larger studies are needed to better target the subset of women who would benefit most from repeated thyroid function monitoring during pregnancy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1530\/ec-24-0151","type":"journal-article","created":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T10:42:01Z","timestamp":1720176121000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-10","source":"Crossref","is-referenced-by-count":3,"title":["Thyroid function monitoring during pregnancy in euthyroid women with thyroid autoimmunity"],"prefix":"10.1530","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9896-4419","authenticated-orcid":true,"given":"Aglaia","family":"Kyrilli","sequence":"first","affiliation":[{"name":"Department of Endocrinology, H\u00f4pital Universitaire de Bruxelles (H.U.B.) - H\u00f4pital Erasme, Universit\u00e9 Libre de Bruxelles (ULB), Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Corvilain","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, H\u00f4pital Universitaire de Bruxelles (H.U.B.) - H\u00f4pital Erasme, Universit\u00e9 Libre de Bruxelles (ULB), Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofie","family":"Bliddal","sequence":"additional","affiliation":[{"name":"Department of Medical Endocrinology and Metabolism, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark"},{"name":"Department of Gynecology and Obstetrics, Copenhagen University Hospital (Hvidovre Hospital), Hvidovre, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorthe Hansen","family":"Precht","sequence":"additional","affiliation":[{"name":"Department of Medical Endocrinology and Metabolism, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark"},{"name":"Carelink N\u00e6rhospital, Roskilde, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulla","family":"Feldt-Rasmussen","sequence":"additional","affiliation":[{"name":"Department of Medical Endocrinology and Metabolism, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark"},{"name":"Institute of Clinical Medicine, Faculty of Health and Clinical Research, Copenhagen University, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kris","family":"Poppe","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Centre Hospitalier Universitaire Saint-Pierre, Brussels, Belgium"},{"name":"Universit\u00e9 Libre de Bruxelles (ULB), Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"bib1","series-title":"Thyroid","first-page":"156","article-title":"Population-based national prevalence of thyroid dysfunction in Spain and associated factors: Di@bet.es study","volume":"27","author":"Vald\u00e9s","year":"2017","unstructured":"Vald\u00e9s SMaldonado-Araque CLago-Sampedro ALillo JAGarcia-Fuentes EPerez-Valero VGutierrez-Repiso COcon-Sanchez PGoday AUrrutia I, et al.Population-based national prevalence of thyroid dysfunction in Spain and associated factors: Di@bet.es study. 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