{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:17:43Z","timestamp":1784557063025,"version":"3.55.0"},"reference-count":0,"publisher":"Bioscientifica","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/deed.en_GB"}],"content-domain":{"domain":["ec.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:p>Objective: Children with a supratentorial midline low grade glioma (LGG) may be at risk for impaired bone health due to hypothalamic-pituitary dysfunction, obesity, exposure to multiple treatment modalities, and\/or decreased mobility. The presence of impaired bone health and\/or its severity in this population has been understudied. We aimed to identify the prevalence and risk factors for bone problems in children with supratentorial midline LGG.<\/jats:p>\n                  <jats:p>Design and Methods: A retrospective study was performed in children with supratentorial midline (suprasellar or thalamic) LGG between 1-1-2003 and 1-1-2022, visiting the Princess M\u00e1xima Center for Pediatric Oncology. Impaired bone health was defined as presence of vertebral fractures and\/or very low bone mineral density (BMD).<\/jats:p>\n                  <jats:p>Results: In total, 161 children were included, with a median age at tumor diagnosis of 4.7 years (range 0.1 \u2013 17.9) and a median follow-up of 6.1 years (range 0.1 \u2013 19.9). Five patients (3.1 %) had vertebral fractures. In 99 patients BMD was assessed either by Dual Energy X ray Absorptiometry (n=12) or Bone Health Index (n=95); 34 patients (34.3%) had a low BMD (\u2264 -2.0). Impaired visual capacity was associated with bone problems in multivariable analysis (OR 6.63, 95% CI 1.83 \u2013 24.00, p = 0.004).<\/jats:p>\n                  <jats:p>Conclusions: In this retrospective evaluation, decreased BMD was prevalent in 34.3% of children with supratentorial midline LGG. For the risk to develop bone problems visual capacity seems highly relevant. Surveillance of bone health must be an aspect for awareness in the care and follow-up of children with a supratentorial midline LGG.<\/jats:p>","DOI":"10.1530\/ec-24-0224","type":"journal-article","created":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T06:47:27Z","timestamp":1723618047000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-10","source":"Crossref","is-referenced-by-count":0,"title":["Bone health in childhood low grade glioma; an understudied problem"],"prefix":"10.1530","author":[{"given":"I M.a.a.","family":"van Roessel","sequence":"first","affiliation":[{"name":"I van Roessel, Department of Pediatric Neuro-oncology, Prinses Maxima Centrum voor Kinderoncologie, Utrecht, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Je","family":"Gorter","sequence":"additional","affiliation":[{"name":"J Gorter, Department of Pediatric Neuro-oncology, Prinses Maxima Centrum voor Kinderoncologie, Utrecht, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boudewijn","family":"Bakker","sequence":"additional","affiliation":[{"name":"B Bakker, Department of Pediatric Neuro-oncology, Prinses Maxima Centrum voor Kinderoncologie, Utrecht, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mm","family":"van den Heuvel-Eibrink","sequence":"additional","affiliation":[{"name":"M van den Heuvel-Eibrink, Prinses Maxima Centrum voor Kinderoncologie, Utrecht, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M H","family":"Lequin","sequence":"additional","affiliation":[{"name":"M Lequin, Department of Radiology, Prinses Maxima Centrum voor Kinderoncologie, Utrecht, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"van der Lugt","sequence":"additional","affiliation":[{"name":"J van der Lugt, Department of Pediatric Neuro-oncology, Prinses Maxima Centrum voor Kinderoncologie, Utrecht, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Meijer","sequence":"additional","affiliation":[{"name":"L Meijer, Department of Pediatric Neuro-oncology, Prinses Maxima Centrum voor Kinderoncologie, Utrecht, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.y.n.","family":"Schouten-van Meeteren","sequence":"additional","affiliation":[{"name":"A Schouten-van Meeteren, Department of Pediatric Neuro-oncology, Prinses Maxima Centrum voor Kinderoncologie, Utrecht, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H M","family":"van Santen","sequence":"additional","affiliation":[{"name":"H van Santen, Department of Pediatric Neuro-oncology, Prinses Maxima Centrum voor Kinderoncologie, Utrecht, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","container-title":["Endocrine Connections"],"original-title":[],"link":[{"URL":"https:\/\/ec.bioscientifica.com\/view\/journals\/ec\/aop\/ec-24-0224\/ec-24-0224.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ec.bioscientifica.com\/downloadpdf\/journals\/ec\/aop\/ec-24-0224\/ec-24-0224.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/ec.bioscientifica.com\/downloadpdf\/journals\/ec\/aop\/ec-24-0224\/ec-24-0224.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:47:20Z","timestamp":1784555240000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.bioscientifica.com\/ec\/article\/1209"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1530\/ec-24-0224","relation":{},"ISSN":["2049-3614","2049-3614"],"issn-type":[{"value":"2049-3614","type":"print"},{"value":"2049-3614","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8]]}}}