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A personalized therapeutic approach is necessary to improve PCOS, focusing on patients\u2019 main concerns, with the goal of addressing ovarian dysfunction, reducing hyperandrogenism and improving metabolic alterations, particularly through weight reduction. The therapeutic class of glucagon-like peptide-1 receptor analogues (GLP-1 RAs) represents an attractive option for PCOS due to its various beneficial effects, such as weight loss. In this review, we discuss the clinical and pathological aspects of PCOS, as well as the data and potential roles of GLP-1 RAs in managing this condition.<\/jats:p>","DOI":"10.1530\/ec-24-0529","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T08:41:11Z","timestamp":1741682471000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-10","source":"Crossref","is-referenced-by-count":20,"title":["Endocrine and metabolic effects of GLP-1 receptor agonists on women with PCOS, a narrative review"],"prefix":"10.1530","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4135-5436","authenticated-orcid":true,"given":"Marine","family":"Monney","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Diabetes, Nutrition and Therapeutic Patient Education, Department of Medical Specialties, Geneva University Hospitals 1 , ,","place":["Geneva, 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