{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T18:28:09Z","timestamp":1790101689715,"version":"4.0.1"},"reference-count":85,"publisher":"Bioscientifica","issue":"10","license":[{"start":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T00:00:00Z","timestamp":1770681600000},"content-version":"vor","delay-in-days":145,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,10,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Thyroid cancer (TC) is a prevalent endocrine malignancy with rising global incidence, particularly among women. Emerging evidence suggests a significant association between type 2 diabetes mellitus (T2D) and TC, potentially mediated by hyperinsulinemia, insulin resistance, and chronic inflammation. However, the molecular mechanisms linking these diseases remain poorly understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We integrated transcriptomic datasets from the Gene Expression Omnibus (GEO) database (GSE33630, GSE35570, GSE60542 for TC; GSE86468 for T2D) to identify shared differentially expressed genes (DEGs). Functional enrichment, protein\u2013protein interaction networks, and Cox regression analyses were employed to elucidate pathways and prognostic biomarkers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We identified 28 shared DEGs between TC and T2D, with CD44, TGFBI, RUNX2, and GJA1 as key hub genes. Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis highlighted pathways involving cell adhesion, extracellular matrix remodeling, and NF-\u03baB signaling. A risk model incorporating seven genes (e.g., PRDM1 [protective] and ZFPM2 [risk]) stratified TC patients into high- and low-risk groups with distinct survival outcomes (P = 0.017).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>T2D and TC exhibit overlapping genetic dysregulation, particularly in pathways governing metabolic reprogramming and tumor microenvironment crosstalk. Notably, PRDM1 and ZFPM2 may serve as therapeutic targets for TC in patients with concurrent diabetes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1530\/ec-25-0181","type":"journal-article","created":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T12:47:09Z","timestamp":1758199629000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-10","source":"Crossref","is-referenced-by-count":2,"title":["Shared molecular mechanisms between type 2 diabetes and thyroid cancer: integrated bioinformatics insights for prognostic biomarker discovery"],"prefix":"10.1530","volume":"14","author":[{"given":"Jiahui","family":"Qi","sequence":"first","affiliation":[{"name":"Institute of Aging, Key Laboratory of Alzheimer\u2019s Disease of Zhejiang Province, Wenzhou Medical University 1 , , ,","place":["Wenzhou, Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanzhi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Thyroid Surgery, National Key Clinical Specialty (General Surgery), The First Affiliated Hospital of Wenzhou Medical University 2 , , ,","place":["Wenzhou, Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Child Healthcare, The Third Clinical Institute Affiliated to Wenzhou Medical University 3 , , ,","place":["Wenzhou, Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuankai","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, The First Affiliated Hospital of Wenzhou Medical University 4 , , ,","place":["Wenzhou, Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5530-9994","authenticated-orcid":true,"given":"Yue","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Metebolic Surgery, Shanghai Tenth People\u2019s Hospital, Tongji University School of Medicine 5 , ,","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","published-online":{"date-parts":[[2025,9,18]]},"reference":[{"key":"2026070711010423300_bib1","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/S2213-8587(22)00035-3","article-title":"The epidemiological landscape of thyroid cancer worldwide: GLOBOCAN estimates for incidence and mortality rates in 2020","volume":"10","author":"Pizzato","year":"2022","journal-title":"Lancet Diabetes Endocrinol"},{"key":"2026070711010423300_bib2","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/s41574-019-0263-x","article-title":"Geographic influences in the global rise of thyroid cancer","volume":"16","author":"Kim","year":"2020","journal-title":"Nat Rev Endocrinol"},{"key":"2026070711010423300_bib3","doi-asserted-by":"crossref","first-page":"6172","DOI":"10.3390\/cancers14246172","article-title":"Thyroid carcinoma: a review for 25 years of environmental risk factors studies","volume":"14","author":"Kruger","year":"2022","journal-title":"Cancers"},{"key":"2026070711010423300_bib4","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.1099280","article-title":"Molecular features of aggressive thyroid cancer","volume":"12","author":"Elia","year":"2022","journal-title":"Front Oncol"},{"key":"2026070711010423300_bib5","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1056\/NEJMra1501993","article-title":"Biologic and clinical perspectives on thyroid cancer","volume":"375","author":"Fagin","year":"2016","journal-title":"N Engl J Med"},{"key":"2026070711010423300_bib6","first-page":"2934","article-title":"Investigating the clinical role and prognostic value of genes related to insulin-like growth factor signaling pathway in thyroid cancer","volume":"16","author":"Liu","year":"2024","journal-title":"Aging"},{"key":"2026070711010423300_bib7","doi-asserted-by":"crossref","first-page":"555","DOI":"10.3390\/cancers14030555","article-title":"Impaired glucose metabolism, anti-diabetes medications, and risk of thyroid cancer","volume":"14","author":"Kushchayeva","year":"2022","journal-title":"Cancers"},{"key":"2026070711010423300_bib8","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.971213","article-title":"Different types of diabetes mellitus and risk of thyroid cancer: a meta-analysis of cohort studies","volume":"13","author":"Dong","year":"2022","journal-title":"Front Endocrinol"},{"key":"2026070711010423300_bib9","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1210\/er.2018-00163","article-title":"Thyroid dysfunction and diabetes mellitus: two closely associated disorders","volume":"40","author":"Biondi","year":"2019","journal-title":"Endocr Rev"},{"key":"2026070711010423300_bib10","doi-asserted-by":"crossref","first-page":"2106","DOI":"10.2337\/dc20-0207","article-title":"Postpancreatitis diabetes confers higher risk for pancreatic cancer than type 2 diabetes: results from a nationwide cancer registry","volume":"43","author":"Cho","year":"2020","journal-title":"Diabetes Care"},{"key":"2026070711010423300_bib11","doi-asserted-by":"crossref","DOI":"10.1093\/jnci\/djv178","article-title":"Evidence of a causal association between insulinemia and endometrial cancer: a mendelian randomization analysis","volume":"107","author":"Nead","year":"2015","journal-title":"J Natl Cancer Inst"},{"key":"2026070711010423300_bib12","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1038\/s41416-018-0314-4","article-title":"Type 2 diabetes and risk of colorectal cancer in two large U.S. prospective cohorts","volume":"119","author":"Ma","year":"2018","journal-title":"Br J Cancer"},{"key":"2026070711010423300_bib13","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.annonc.2020.12.008","article-title":"A prospective study of type 2 diabetes, metformin use, and risk of breast cancer","volume":"32","author":"Park","year":"2021","journal-title":"Ann Oncol"},{"key":"2026070711010423300_bib14","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1002\/hep4.1891","article-title":"Risk associations of glycemic burden and obesity with liver cancer-A 10-year analysis of 15,280 patients with type 2 diabetes","volume":"6","author":"Mao","year":"2022","journal-title":"Hepatol Commun"},{"key":"2026070711010423300_bib15","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1136\/jech-2023-221351","article-title":"Type 2 diabetes, glycaemic traits and upper gastrointestinal cancer risk: a prospective cohort study","volume":"78","author":"Cao","year":"2024","journal-title":"J Epidemiol Community Health"},{"key":"2026070711010423300_bib16","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/cas.12043","article-title":"Diabetes mellitus and cancer risk: review of the epidemiological evidence","volume":"104","author":"Shikata","year":"2013","journal-title":"Cancer Sci"},{"key":"2026070711010423300_bib17","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1159\/000289594","article-title":"Genetic susceptibility to type 2 diabetes is associated with reduced prostate cancer risk","volume":"69","author":"Pierce","year":"2010","journal-title":"Hum Hered"},{"key":"2026070711010423300_bib18","doi-asserted-by":"crossref","DOI":"10.1002\/jcla.23531","article-title":"Insulin-like growth factor 1 promotes proliferation and invasion of papillary thyroid cancer through the STAT3 pathway","volume":"34","author":"Yang","year":"2020","journal-title":"J Clin Lab Anal"},{"key":"2026070711010423300_bib19","article-title":"Damaging missense variants in IGF1R implicate a role for IGF-1 resistance in the etiology of type 2 diabetes","volume":"2","author":"Gardner","year":"2022","journal-title":"Cell Genom"},{"key":"2026070711010423300_bib20","doi-asserted-by":"crossref","DOI":"10.1530\/EC-23-0257","article-title":"Glucagon-like peptide 1 receptor agonists and thyroid cancer: is it the time to be concerned?","volume":"12","author":"Lisco","year":"2023","journal-title":"Endocr Connect"},{"key":"2026070711010423300_bib21","doi-asserted-by":"crossref","first-page":"384","DOI":"10.2337\/dc22-1148","article-title":"GLP-1 receptor agonists and the risk of thyroid cancer","volume":"46","author":"Bezin","year":"2023","journal-title":"Diabetes Care"},{"key":"2026070711010423300_bib22","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1186\/s13046-019-1309-6","article-title":"Effects of hyperglycemia on the progression of tumor diseases","volume":"38","author":"Li","year":"2019","journal-title":"J Exp Clin Cancer Res"},{"key":"2026070711010423300_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2025.108376","article-title":"Human tau promotes Warburg effect-like glycolytic metabolism under acute hyperglycemia conditions","volume":"301","author":"Yao","year":"2025","journal-title":"J Biol Chem"},{"key":"2026070711010423300_bib24","doi-asserted-by":"crossref","first-page":"347","DOI":"10.3389\/fendo.2017.00347","article-title":"Alterations in mitochondrial oxidative stress and mitophagy in subjects with prediabetes and type 2 diabetes mellitus","volume":"8","author":"Bhansali","year":"2017","journal-title":"Front Endocrinol"},{"key":"2026070711010423300_bib25","doi-asserted-by":"crossref","first-page":"R131","DOI":"10.1530\/ERC-18-0476","article-title":"Oxidative stress in thyroid carcinomas: biological and clinical significance","volume":"26","author":"Ameziane El Hassani","year":"2019","journal-title":"Endocr Relat Cancer"},{"key":"2026070711010423300_bib26","doi-asserted-by":"crossref","first-page":"3180","DOI":"10.18632\/aging.101143","article-title":"Effect of the micronutrient iodine in thyroid carcinoma angiogenesis","volume":"8","author":"Daniell","year":"2016","journal-title":"Aging"},{"key":"2026070711010423300_bib27","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.862545","article-title":"Increased serum VEGF-B level is associated with renal function impairment in patients with type 2 diabetes","volume":"13","author":"Wei","year":"2022","journal-title":"Front Endocrinol"},{"key":"2026070711010423300_bib28","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.829009","article-title":"Glucose-to-Lymphocyte Ratio (GLR) as a predictor of preoperative central lymph node metastasis in papillary thyroid cancer patients with type 2 diabetes mellitus and construction of the nomogram","volume":"13","author":"Jin","year":"2022","journal-title":"Front Endocrinol"},{"key":"2026070711010423300_bib29","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.7150\/jca.71514","article-title":"Fasting serum glucose and lymph node metastasis in non-diabetic PTC patients: a 10-Year multicenter retrospective study","volume":"13","author":"Liu","year":"2022","journal-title":"J Cancer"},{"key":"2026070711010423300_bib30","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1007\/s12020-020-02291-8","article-title":"Effect of type 2 diabetes and antihyperglycemic drug therapy on signs of tumor invasion in papillary thyroid cancer","volume":"69","author":"Li","year":"2020","journal-title":"Endocrine"},{"key":"2026070711010423300_bib31","article-title":"Abnormal glucose metabolism parameters and the aggressiveness of differentiated thyroid carcinoma: a hospital-based cross-section study in China","volume":"13","author":"Zhao","year":"2022","journal-title":"Front Endocrinol"},{"key":"2026070711010423300_bib32","doi-asserted-by":"crossref","first-page":"D607","DOI":"10.1093\/nar\/gky1131","article-title":"STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets","volume":"47","author":"Szklarczyk","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"2026070711010423300_bib33","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1186\/s13059-019-1758-4","article-title":"Cytoscape automation: empowering workflow-based network analysis","volume":"20","author":"Otasek","year":"2019","journal-title":"Genome Biol"},{"key":"2026070711010423300_bib34","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0098135","article-title":"Diabetes mellitus and risk of thyroid cancer: a meta-analysis","volume":"9","author":"Yeo","year":"2014","journal-title":"PLoS One"},{"key":"2026070711010423300_bib35","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.amjoto.2015.02.015","article-title":"Relationship between obesity, diabetes and the risk of thyroid cancer","volume":"36","author":"Oberman","year":"2015","journal-title":"Am J Otolaryngol"},{"key":"2026070711010423300_bib36","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.ijsu.2018.07.013","article-title":"The association between thyroid cancer and insulin resistance, metabolic syndrome and its components: a systematic review and meta-analysis","volume":"57","author":"Yin","year":"2018","journal-title":"Int J Surg"},{"key":"2026070711010423300_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2024.116450","article-title":"Hyperglycemia-driven signaling bridges between diabetes and cancer","volume":"229","author":"Ghareghomi","year":"2024","journal-title":"Biochem Pharmacol"},{"key":"2026070711010423300_bib38","doi-asserted-by":"crossref","first-page":"314","DOI":"10.3389\/fendo.2017.00314","article-title":"Insulin resistance: any role in the changing epidemiology of thyroid cancer?","volume":"8","author":"Malaguarnera","year":"2017","journal-title":"Front Endocrinol"},{"key":"2026070711010423300_bib39","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s11154-023-09849-7","article-title":"Thyroid cancer and insulin resistance","volume":"25","author":"Brenta","year":"2024","journal-title":"Rev Endocr Metab Disord"},{"key":"2026070711010423300_bib40","doi-asserted-by":"crossref","first-page":"R17","DOI":"10.1530\/JME-19-0083","article-title":"The role of an anti-diabetic drug metformin in the treatment of endocrine tumors","volume":"63","author":"Thakur","year":"2019","journal-title":"J Mol Endocrinol"},{"key":"2026070711010423300_bib41","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0279591","article-title":"Metformin and thyroid carcinoma incidence and prognosis: a systematic review and meta-analysis","volume":"17","author":"Wang","year":"2022","journal-title":"PLoS One"},{"key":"2026070711010423300_bib42","first-page":"61","article-title":"The relation of serum anti-(GalNAc beta) and -para-Forssman disaccharide IgG levels to the progression and histological grading of gastrointestinal cancer","volume":"29","author":"Smorodin","year":"2007","journal-title":"Exp Oncol"},{"key":"2026070711010423300_bib43","doi-asserted-by":"crossref","first-page":"e59","DOI":"10.1371\/journal.pcbi.0030059","article-title":"The importance of bottlenecks in protein networks: correlation with gene essentiality and expression dynamics","volume":"3","author":"Yu","year":"2007","journal-title":"PLoS Comput Biol"},{"key":"2026070711010423300_bib44","doi-asserted-by":"crossref","first-page":"W438","DOI":"10.1093\/nar\/gkn257","article-title":"Hubba: hub objects analyzer \u2013 a framework of interactome hubs identification for network biology","volume":"36","author":"Lin","year":"2008","journal-title":"Nucleic Acids Res"},{"key":"2026070711010423300_bib45","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1158\/0008-5472.CAN-11-3320","article-title":"CD44 proteolysis increases CREB phosphorylation and sustains proliferation of thyroid cancer cells","volume":"72","author":"De Falco","year":"2012","journal-title":"Cancer Res"},{"key":"2026070711010423300_bib46","doi-asserted-by":"crossref","first-page":"7049","DOI":"10.1073\/pnas.1114513109","article-title":"Expression-based genome-wide association study links the receptor CD44 in adipose tissue with type 2 diabetes","volume":"109","author":"Kodama","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026070711010423300_bib47","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1161\/CIRCRESAHA.115.306341","article-title":"Transcription factor Runx2 promotes aortic fibrosis and stiffness in type 2 diabetes mellitus","volume":"117","author":"Raaz","year":"2015","journal-title":"Circ Res"},{"key":"2026070711010423300_bib48","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1038\/labinvest.2012.84","article-title":"Transcription factor Runx2 is a regulator of epithelial-mesenchymal transition and invasion in thyroid carcinomas","volume":"92","author":"Niu","year":"2012","journal-title":"Lab Invest"},{"key":"2026070711010423300_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.112180","article-title":"TGFBI: a novel therapeutic target for cancer","volume":"134","author":"Huang","year":"2024","journal-title":"Int Immunopharmacol"},{"key":"2026070711010423300_bib50","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1530\/ERC-19-0008","article-title":"Exosomes increased angiogenesis in papillary thyroid cancer microenvironment","volume":"26","author":"Wu","year":"2019","journal-title":"Endocr Relat Cancer"},{"key":"2026070711010423300_bib51","doi-asserted-by":"crossref","first-page":"4597","DOI":"10.1093\/hmg\/ddu173","article-title":"TGFBI (betaIG-H3) is a diabetes-risk gene based on mouse and human genetic studies","volume":"23","author":"Han","year":"2014","journal-title":"Hum Mol Genet"},{"key":"2026070711010423300_bib52","doi-asserted-by":"crossref","first-page":"693","DOI":"10.3390\/ijms19030693","article-title":"The complex subtype-dependent role of connexin 43 (GJA1) in breast cancer","volume":"19","author":"Busby","year":"2018","journal-title":"Int J Mol Sci"},{"key":"2026070711010423300_bib53","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.canlet.2018.10.043","article-title":"Connexin 43 (Cx43) in cancer: implications for therapeutic approaches via gap junctions","volume":"442","author":"Bonacquisti","year":"2019","journal-title":"Cancer Lett"},{"key":"2026070711010423300_bib54","doi-asserted-by":"crossref","first-page":"11649","DOI":"10.2147\/CMAR.S235500","article-title":"GJA1 is a prognostic biomarker and correlated with immune infiltrates in colorectal cancer","volume":"12","author":"Hu","year":"2020","journal-title":"Cancer Manag Res"},{"key":"2026070711010423300_bib55","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/8827920","article-title":"GJA1 expression and its prognostic value in cervical cancer","volume":"2020","author":"Meng","year":"2020","journal-title":"Biomed Res Int"},{"key":"2026070711010423300_bib56","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.1074\/jbc.REV119.007759","article-title":"Cell adhesion in cancer: beyond the migration of single cells","volume":"295","author":"Janiszewska","year":"2020","journal-title":"J Biol Chem"},{"key":"2026070711010423300_bib57","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1186\/s12967-018-1642-0","article-title":"Cell adhesion-related gene somatic mutations are enriched in aggressive papillary thyroid microcarcinomas","volume":"16","author":"Song","year":"2018","journal-title":"J Transl Med"},{"key":"2026070711010423300_bib58","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.3892\/ol.2016.4104","article-title":"Intercellular adhesion molecule 1 is a sensitive and diagnostically useful immunohistochemical marker of papillary thyroid cancer (PTC) and of PTC-like nuclear alterations in Hashimoto\u2019s thyroiditis","volume":"11","author":"Zhang","year":"2016","journal-title":"Oncol Lett"},{"key":"2026070711010423300_bib59","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1177\/15353702221090464","article-title":"Is type 2 diabetes mellitus another intercellular junction-related disorder?","volume":"247","author":"Collares-Buzato","year":"2022","journal-title":"Exp Biol Med"},{"key":"2026070711010423300_bib60","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1080\/08830180802276179","article-title":"NF-kappaB signaling pathway and its therapeutic implications in human diseases","volume":"27","author":"Sarkar","year":"2008","journal-title":"Int Rev Immunol"},{"key":"2026070711010423300_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101172","article-title":"Interactions between plasma copper concentrations and SOD1 gene polymorphism for impaired glucose regulation and type 2 diabetes","volume":"24","author":"Yin","year":"2019","journal-title":"Redox Biol"},{"key":"2026070711010423300_bib62","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1507\/endocrj.K09E-051","article-title":"Role of copper ion in the pathogenesis of type 2 diabetes","volume":"56","author":"Tanaka","year":"2009","journal-title":"Endocr J"},{"key":"2026070711010423300_bib63","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.202300468","article-title":"Copper and diabetes: current research and prospect","volume":"67","author":"Chang","year":"2023","journal-title":"Mol Nutr Food Res"},{"key":"2026070711010423300_bib64","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/s41568-021-00417-2","article-title":"Connecting copper and cancer: from transition metal signalling to metalloplasia","volume":"22","author":"Ge","year":"2022","journal-title":"Nat Rev Cancer"},{"key":"2026070711010423300_bib65","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.ctrv.2008.07.004","article-title":"Elevated copper and oxidative stress in cancer cells as a target for cancer treatment","volume":"35","author":"Gupte","year":"2009","journal-title":"Cancer Treat Rev"},{"key":"2026070711010423300_bib66","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.canlet.2015.12.014","article-title":"Blockade of the interaction between Bcr-Abl and PTB1B by small molecule SBF-1 to overcome imatinib-resistance of chronic myeloid leukemia cells","volume":"372","author":"Elgehama","year":"2016","journal-title":"Cancer Lett"},{"key":"2026070711010423300_bib67","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/cas.15580","article-title":"Targeting the PTP1B-Bcr-Abl1 interaction for the degradation of T315I mutant Bcr-Abl1 in chronic myeloid leukemia","volume":"114","author":"Elgehama","year":"2023","journal-title":"Cancer Sci"},{"key":"2026070711010423300_bib68","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/j.csbj.2024.02.015","article-title":"Uncovering the potential of APOD as a biomarker in gastric cancer: a retrospective and multi-center study","volume":"23","author":"Wang","year":"2024","journal-title":"Comput Struct Biotechnol J"},{"key":"2026070711010423300_bib69","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1186\/s12905-022-02083-4","article-title":"A risk prediction model mediated by genes of APOD\/APOC1\/SQLE associates with prognosis in cervical cancer","volume":"22","author":"Zhang","year":"2022","journal-title":"BMC Womens Health"},{"key":"2026070711010423300_bib70","article-title":"CPXM1 correlates to poor prognosis and immune cell infiltration in gastric cancer","volume":"10","author":"Gu","year":"2024","journal-title":"Heliyon"},{"key":"2026070711010423300_bib71","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1158\/1078-0432.CCR-20-2166","article-title":"An immune-related gene prognostic index for head and neck squamous cell carcinoma","volume":"27","author":"Chen","year":"2021","journal-title":"Clin Cancer Res"},{"key":"2026070711010423300_bib72","doi-asserted-by":"crossref","first-page":"3343","DOI":"10.3390\/cancers13133343","article-title":"Identification of a novel tumor microenvironment prognostic signature for advanced-stage serous ovarian cancer","volume":"13","author":"Zheng","year":"2021","journal-title":"Cancers"},{"key":"2026070711010423300_bib73","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1007\/s00404-020-05524-3","article-title":"A 10-gene prognostic methylation signature for stage I-III cervical cancer","volume":"301","author":"Cai","year":"2020","journal-title":"Arch Gynecol Obstet"},{"key":"2026070711010423300_bib74","doi-asserted-by":"crossref","first-page":"5274","DOI":"10.3390\/cancers15215274","article-title":"DNA methylation aberrations in dimethylarsinic acid-induced bladder carcinogenesis","volume":"15","author":"Yamamoto","year":"2023","journal-title":"Cancers"},{"key":"2026070711010423300_bib75","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1186\/s13046-020-01664-1","article-title":"Long noncoding RNA ZFPM2-AS1 acts as a miRNA sponge and promotes cell invasion through regulation of miR-139\/GDF10 in hepatocellular carcinoma","volume":"39","author":"He","year":"2020","journal-title":"J Exp Clin Cancer Res"},{"key":"2026070711010423300_bib76","first-page":"1760","article-title":"Low metallothionein 1M (MT1M) is associated with thyroid cancer cell lines progression","volume":"11","author":"Chen","year":"2019","journal-title":"Am J Transl Res"},{"key":"2026070711010423300_bib77","doi-asserted-by":"crossref","first-page":"2568","DOI":"10.1093\/carcin\/bgs287","article-title":"Metallothionein MT1M is a tumor suppressor of human hepatocellular carcinomas","volume":"33","author":"Mao","year":"2012","journal-title":"Carcinogenesis"},{"key":"2026070711010423300_bib78","doi-asserted-by":"crossref","first-page":"4723","DOI":"10.3748\/wjg.v20.i16.4723","article-title":"MT1M and MT1G promoter methylation as biomarkers for hepatocellular carcinoma","volume":"20","author":"Ji","year":"2014","journal-title":"World J Gastroenterol"},{"key":"2026070711010423300_bib79","doi-asserted-by":"crossref","first-page":"267","DOI":"10.14348\/molcells.2021.2179","article-title":"Metallothionein MT1M suppresses carcinogenesis of esophageal carcinoma cells through inhibition of the epithelial-mesenchymal transition and the SOD1\/PI3K axis","volume":"44","author":"Li","year":"2021","journal-title":"Mol Cells"},{"key":"2026070711010423300_bib80","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1007\/s00125-019-05008-3","article-title":"Metallothionein 1 negatively regulates glucose-stimulated insulin secretion and is differentially expressed in conditions of beta cell compensation and failure in mice and humans","volume":"62","author":"Bensellam","year":"2019","journal-title":"Diabetologia"},{"key":"2026070711010423300_bib81","first-page":"E5066","article-title":"PRDM1 silences stem cell-related genes and inhibits proliferation of human colon tumor organoids","volume":"115","author":"Liu","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026070711010423300_bib82","doi-asserted-by":"crossref","first-page":"20119","DOI":"10.1073\/pnas.1115128108","article-title":"PRDM1 is a tumor suppressor gene in natural killer cell malignancies","volume":"108","author":"Kucuk","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026070711010423300_bib83","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1038\/ng.468","article-title":"A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus","volume":"41","author":"Gateva","year":"2009","journal-title":"Nat Genet"},{"key":"2026070711010423300_bib84","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.1111\/cas.13384","article-title":"Diagnostic and prognostic role of urinary collagens in primary human bladder cancer","volume":"108","author":"Miyake","year":"2017","journal-title":"Cancer Sci"},{"key":"2026070711010423300_bib85","doi-asserted-by":"crossref","first-page":"3959","DOI":"10.3390\/cancers14163959","article-title":"Transcriptomic profiling analysis of castration-resistant prostate cancer cell lines treated with chronic intermittent hypoxia","volume":"14","author":"Lee","year":"2022","journal-title":"Cancers"}],"container-title":["Endocrine Connections"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ec.bioscientifica.com\/view\/journals\/ec\/14\/10\/EC-25-0181.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ec.bioscientifica.com\/downloadpdf\/journals\/ec\/14\/10\/EC-25-0181.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.bioscientifica.com\/ec\/article-pdf\/doi\/10.1530\/EC-25-0181\/9822\/ec-25-0181.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.bioscientifica.com\/ec\/article-pdf\/doi\/10.1530\/EC-25-0181\/9822\/ec-25-0181.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T15:33:57Z","timestamp":1783438437000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.bioscientifica.com\/ec\/article\/14\/10\/e250181\/1441\/Shared-molecular-mechanisms-between-type-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,18]]},"references-count":85,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10,1]]}},"URL":"https:\/\/doi.org\/10.1530\/ec-25-0181","relation":{},"ISSN":["2049-3614"],"issn-type":[{"value":"2049-3614","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,18]]},"article-number":"e250181"}}