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Recent studies have highlighted mitochondrial dysfunction as a crucial factor in the complex pathogenesis of PCOS, suggesting that the health of these cellular powerhouses plays a pivotal role in the condition. This review meticulously examines the effects of mitochondrial dysfunction specifically in ovarian granulosa cells, delving into the intricate mechanisms of action that contribute to the development and progression of PCOS, as well as identifying potential therapeutic targets that could be explored for effective treatment. By thoroughly analyzing the relevant literature and synthesizing findings from various studies, this paper aims to provide new insights into the multifaceted nature of PCOS research and promote advancements in clinical treatment strategies that could ultimately improve the health and well-being of women affected by this disorder.<\/jats:p>","DOI":"10.1530\/ec-25-0186","type":"journal-article","created":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T07:50:53Z","timestamp":1751269853000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-10","source":"Crossref","is-referenced-by-count":20,"title":["The role of mitochondrial dysfunction in ovarian granulosa cells in polycystic ovary syndrome"],"prefix":"10.1530","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8635-2979","authenticated-orcid":true,"given":"Xuejun","family":"Yan","sequence":"first","affiliation":[{"name":"NHC Key Laboratory of Birth Defect for Research and Prevention, Hunan Provincial Maternal and Child Health Care Hospital 1 , , ,","place":["Changsha, Hunan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Ma","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Birth Defect for Research and Prevention, Hunan Provincial Maternal and Child Health Care Hospital 1 , , ,","place":["Changsha, Hunan, China"]},{"name":"Department of Obstetrics and Gynecology, Hunan Provincial Maternal and Child Health Care Hospital 2 , , ,","place":["Changsha, Hunan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongnian","family":"Li","sequence":"additional","affiliation":[{"name":"Xiangtan Hospital of Traditional Chinese Medicine 3 , , ,","place":["Xiangtan, Hunan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Xu","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Birth Defect for Research and Prevention, Hunan Provincial Maternal and Child Health Care Hospital 1 , , ,","place":["Changsha, Hunan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zou","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Birth Defect for Research and Prevention, Hunan Provincial Maternal and Child Health Care Hospital 1 , , ,","place":["Changsha, Hunan, China"]},{"name":"Department of Obstetrics and Gynecology, Hunan Provincial Maternal and Child Health Care Hospital 2 , , ,","place":["Changsha, Hunan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minmin","family":"He","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Birth Defect for Research and Prevention, Hunan Provincial Maternal and Child Health Care Hospital 1 , , ,","place":["Changsha, Hunan, China"]},{"name":"Department of Obstetrics and Gynecology, Hunan Provincial Maternal and Child Health Care Hospital 2 , , ,","place":["Changsha, Hunan, 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