{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T11:13:34Z","timestamp":1783941214759,"version":"3.55.0"},"reference-count":30,"publisher":"Bioscientifica","issue":"9","license":[{"start":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T00:00:00Z","timestamp":1770681600000},"content-version":"vor","delay-in-days":162,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,9,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Meteorin-like protein (Metrnl) is considered a novel adipokine, which plays an important role in the occurrence and development of type 2 diabetes mellitus (T2DM). In a previous meta-analysis, no significant difference in circulating Metrnl levels was found between T2DM patients and normal glucose tolerance individuals. However, these meta-analyses included limited studies, and more studies about Metrnl and T2DM were published recently. Therefore, the association between Metrnl and T2DM remains uncertain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This study aimed to systematically and comprehensively update the relationship between circulating Metrnl levels and T2DM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic search was conducted on the Web of Science, Wiley Online Library, PubMed, and Ovid databases using the terms \u2018type 2 diabetes mellitus\u2019 in combination with \u2018Metrnl\u2019. Meta-analysis results were reported as standardized mean differences (SMDs) with corresponding 95% confidence intervals (CIs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total, 17 studies, including 649 patients with T2DM and 396 healthy controls, were included in the meta-analysis. We found that circulating Metrnl levels were lower in patients with T2DM than in healthy individuals (SMD: \u22120.47, 95% CI: (\u22120.98, 0.05); prediction interval: (\u22123.66, 2.73)). Moreover, serum Metrnl levels in patients with T2DM were significantly lower than in healthy individuals (SMD: \u22120.91, 95% CI: (\u22121.60, \u22120.22); prediction interval: (\u22125.03, 3.21)).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study aimed to systematically and comprehensively update the relationship between circulating Metrnl levels and T2DM. A clearer understanding of the role of Metrnl in T2DM could facilitate the development of effective treatments.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1530\/ec-25-0452","type":"journal-article","created":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T16:37:51Z","timestamp":1758040671000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-10","source":"Crossref","is-referenced-by-count":2,"title":["Relationship between Meteorin-like protein and type 2 diabetes mellitus: an update and meta-analysis"],"prefix":"10.1530","volume":"14","author":[{"given":"Jing","family":"Xie","sequence":"first","affiliation":[{"name":"Department of Endocrinology, First Affiliated Hospital of Soochow University 1 , ,","place":["Suzhou, P.R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhua","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Fourth People\u2019s Hospital of Shenyang 2 , ,","place":["Shenyang, P.R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayi","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, First Affiliated Hospital of Soochow University 1 , ,","place":["Suzhou, P.R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, First Affiliated Hospital of Soochow University 1 , ,","place":["Suzhou, P.R. 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