{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T18:19:15Z","timestamp":1783448355305,"version":"3.55.0"},"reference-count":57,"publisher":"Bioscientifica","issue":"11","license":[{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"vor","delay-in-days":226,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,11,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the correlation between insulin receptor (IR) expression and patients\u2019 preoperative blood glucose level, and to analyze the correlation between IR expression level (IR percentage) and well-differentiated pancreatic neuroendocrine neoplasms (pNENs) cell proliferation and recurrence, and to explore whether it can be used as a potential biomarker for predicting tumor recurrence and metastasis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective evaluation of the clinical data of 81 patients with well-differentiated pNENs who underwent surgical treatment at five different centers between January 2015 and September 2024 was performed. A subset of patients\u2019 pathological sections was collected for analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Multivariate linear regression analysis revealed that blood glucose (P = 0.024) was the only risk factor for increased Ki-67 expression. Preoperative blood glucose was significantly associated with IR percentage (P = 0.001). There was a significant positive correlation between Ki-67 and IR percentage in patients with G1\u20132 pNENs (P = 0.003). Cox regression analysis showed that IR percentage &amp;gt;12.5% was a good predictor of tumor recurrence (HR = 9.12, P = 0.004).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In patients with G1\u20132 pNENs, IR percentage could effectively predict tumor recurrence and metastasis, indicating that it can be used as a potential biomarker to predict pNEN recurrence and metastasis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1530\/ec-25-0526","type":"journal-article","created":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T12:38:51Z","timestamp":1762951131000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-10","source":"Crossref","is-referenced-by-count":0,"title":["Correlation between insulin receptor expression and tumor cell proliferation, recurrence and metastasis in well-differentiated pancreatic neuroendocrine 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