{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T17:07:40Z","timestamp":1784567260828,"version":"3.55.0"},"reference-count":89,"publisher":"Bioscientifica","issue":"7","license":[{"start":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:00:00Z","timestamp":1783382400000},"content-version":"vor","delay-in-days":6,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The roles of mitochondrial genes in the development of thyroid cancer (TC) and the associated tumor microenvironment remain to be elucidated. Based on 64 dysregulated mitochondrial genes, unsupervised consensus clustering analysis was performed using TC datasets from The Cancer Genome Atlas and integrated gene expression databases. A dysregulated mitochondrial-based prognostic model was constructed using machine learning. Fourteen prognostic genes were identified, and the correlation between semaphorin 7A (SEMA7A) and immune cell infiltration was validated. The functions of SEMA7A were investigated through plate cloning, scratch wound healing, and Transwell invasion assays. This study constructed a prognostic model for predicting overall survival by identifying 14 mitochondrial dysregulated-based prognostic genes (APOD, ATP2C2, FAM111B, GJB4, GZMA, HHIPL2, IFIT3, IL18, MCEMP1, PRRT4, RGS16, SEMA7A, SLC2A3, and TDRD9). Its effectiveness was validated in an independent cohort. The model accurately predicted OS across cancer stages. SEMA7A expression was significantly upregulated in papillary thyroid carcinoma (PTC) tissues and PTC cell lines. Functional experiments showed that SEMA7A promoted TC progression, including cell proliferation, migration, and invasion. Compared with the SEMA7A low-expression group, the high-expression group showed a larger FOXP3+ regulatory T cell (Treg) population. Although a higher ratio of SEMA7A + CD8-positive cells\/SEMA7A + FOXP3-positive cells was observed, increased Treg abundance is known to shift the immune context toward a less cytotoxic and more exhausted state. Thus, oncogenic SEMA7A in TC promotes malignant functions in TC cells and may play an important role in shaping the immunosuppressive microenvironment. Consequently, our mitochondrial dysregulation-based prognostic risk model for TC may offer good clinical application value.<\/jats:p>","DOI":"10.1530\/ec-26-0245","type":"journal-article","created":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T16:46:35Z","timestamp":1784565995000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-10","source":"Crossref","is-referenced-by-count":0,"title":["Mitochondrial gene expression-based model for the prediction of thyroid cancer prognosis"],"prefix":"10.1530","volume":"15","author":[{"given":"Weina","family":"Zha","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Hebei Medical University 1 , ,","place":["Shijiazhuang, China"]},{"name":"Department of Endocrinology I, Tangshan Workers\u2019 Hospital 2 , ,","place":["Tangshan, China"]},{"name":"Tangshan Key Laboratory for Precision Prevention and Treatment of Thyroid and Diabetes Diseases 3 , ,","place":["Tangshan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingwu","family":"Li","sequence":"additional","affiliation":[{"name":"Hebei Key Laboratory of Molecular Oncology 4 , ,","place":["Tangshan, China"]},{"name":"Tangshan Key Laboratory of Cancer Prevention and Therapy 5 , ,","place":["Tangshan, China"]},{"name":"Department of Gastrointestinal Surgery, Tangshan People\u2019s Hospital 6 , ,","place":["Tangshan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufeng","family":"Li","sequence":"additional","affiliation":[{"name":"Hebei Key Laboratory of Molecular Oncology 4 , ,","place":["Tangshan, China"]},{"name":"Tangshan Key Laboratory of Cancer Prevention and Therapy 5 , ,","place":["Tangshan, China"]},{"name":"The Cancer Institute, Tangshan People\u2019s Hospital 7 , ,","place":["Tangshan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanchen","family":"Li","sequence":"additional","affiliation":[{"name":"Information Department, Tangshan Central Blood Station 8 , ,","place":["Tangshan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolin","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology I, Tangshan Workers\u2019 Hospital 2 , ,","place":["Tangshan, China"]},{"name":"Tangshan Key Laboratory for Precision Prevention and Treatment of Thyroid and Diabetes Diseases 3 , ,","place":["Tangshan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Liu","sequence":"additional","affiliation":[{"name":"Hebei Key Laboratory of Molecular Oncology 4 , ,","place":["Tangshan, China"]},{"name":"Tangshan Key Laboratory of Cancer Prevention and Therapy 5 , ,","place":["Tangshan, China"]},{"name":"The Cancer Institute, Tangshan People\u2019s Hospital 7 , ,","place":["Tangshan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology I, Tangshan Workers\u2019 Hospital 2 , ,","place":["Tangshan, China"]},{"name":"Tangshan Key Laboratory for Precision Prevention and Treatment of Thyroid and Diabetes Diseases 3 , ,","place":["Tangshan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology I, Tangshan Workers\u2019 Hospital 2 , ,","place":["Tangshan, China"]},{"name":"Tangshan Key Laboratory for Precision Prevention and Treatment of Thyroid and Diabetes Diseases 3 , ,","place":["Tangshan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingchen","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy and Chemotherapy, Affiliated Hospital of North China University of Science and Technology 9 , ,","place":["Tangshan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology I, Tangshan Workers\u2019 Hospital 2 , ,","place":["Tangshan, China"]},{"name":"Tangshan Key Laboratory for Precision Prevention and Treatment of Thyroid and Diabetes Diseases 3 , ,","place":["Tangshan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7007-1968","authenticated-orcid":true,"given":"Geling","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hebei Medical University 1 , ,","place":["Shijiazhuang, China"]},{"name":"Department of Endocrinology I, Tangshan Workers\u2019 Hospital 2 , ,","place":["Tangshan, China"]},{"name":"Tangshan Key Laboratory for Precision Prevention and Treatment of Thyroid and Diabetes Diseases 3 , ,","place":["Tangshan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","published-online":{"date-parts":[[2026,7,7]]},"reference":[{"key":"2026072012462740000_bib1","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J Clin"},{"key":"2026072012462740000_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/thy.2015.0020","article-title":"2015 American Thyroid Association Management Guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: the American Thyroid Association Guidelines task force on thyroid nodules and differentiated thyroid cancer","volume":"26","author":"Haugen","year":"2016","journal-title":"Thyroid"},{"key":"2026072012462740000_bib3","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1016\/j.surg.2008.08.034","article-title":"The impact of lymph node involvement on survival in patients with papillary and follicular thyroid carcinoma","volume":"144","author":"Zaydfudim","year":"2008","journal-title":"Surgery"},{"key":"2026072012462740000_bib4","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1002\/jso.23090","article-title":"Cervical lymph node metastasis and papillary thyroid carcinoma: does the compartment involved affect survival? Experience from the SEER database","volume":"106","author":"Smith","year":"2012","journal-title":"J Surg Oncol"},{"key":"2026072012462740000_bib5","article-title":"Thyroid cancer-associated mitochondrial DNA mutation G3842A promotes tumorigenicity via ROS-mediated ERK1\/2 activation","volume":"2022","author":"Chen","year":"2022","journal-title":"Oxid Med Cell Longev"},{"key":"2026072012462740000_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2022.147133","article-title":"Development and validation of a mitochondrial energy metabolism-related risk model in hepatocellular carcinoma","volume":"855","author":"Gao","year":"2023","journal-title":"Gene"},{"key":"2026072012462740000_bib7","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1007\/s12672-025-03927-9","article-title":"Utilizing a novel mitochondrial-related gene signature for predicting the prognosis and immunological impact in bladder cancer","volume":"16","author":"Wu","year":"2025","journal-title":"Discov Oncol"},{"key":"2026072012462740000_bib8","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1458264","article-title":"Explore the expression of mitochondria-related genes to construct prognostic risk model for ovarian cancer and validate it, so as to provide optimized treatment for ovarian cancer","volume":"15","author":"Yunyun","year":"2024","journal-title":"Front Immunol"},{"key":"2026072012462740000_bib9","doi-asserted-by":"crossref","first-page":"6667","DOI":"10.3390\/ijms23126667","article-title":"The regulatory roles of mitochondrial calcium and the mitochondrial calcium uniporter in tumor cells","volume":"23","author":"Zhang","year":"2022","journal-title":"Int J Mol Sci"},{"key":"2026072012462740000_bib10","doi-asserted-by":"crossref","first-page":"e288","DOI":"10.1002\/mco2.288","article-title":"Targeting the p53 signaling pathway in cancers: molecular mechanisms and clinical studies","volume":"4","author":"Shen","year":"2023","journal-title":"MedComm"},{"key":"2026072012462740000_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2025.114438","article-title":"ACSS3 promotes the tumorigenesis of non-small cell lung cancer via suppressing p53-mediated ferroptosis","volume":"446","author":"Zhang","year":"2025","journal-title":"Exp Cell Res"},{"key":"2026072012462740000_bib12","article-title":"New prognostic features and personalized treatment strategies of mitochondrial related genes in colorectal cancer patients","volume":"16","author":"Xu","year":"2025","journal-title":"Front Pharmacol"},{"key":"2026072012462740000_bib13","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1461489","article-title":"Mitochondrial-related genes as prognostic and metastatic markers in breast cancer: insights from comprehensive analysis and clinical models","volume":"15","author":"Fang","year":"2024","journal-title":"Front Immunol"},{"key":"2026072012462740000_bib14","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1038\/s41467-024-45366-0","article-title":"Unraveling the role of the mitochondrial one-carbon pathway in undifferentiated thyroid cancer by multi-omics analyses","volume":"15","author":"Lee","year":"2024","journal-title":"Nat Commun"},{"key":"2026072012462740000_bib15","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.semcancer.2021.01.001","article-title":"The central role of mitochondria in the relationship between dietary lipids and cancer progression","volume":"73","author":"Varela-L\u00f3pez","year":"2021","journal-title":"Semin Cancer Biol"},{"key":"2026072012462740000_bib16","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.974087","article-title":"The role of immune profile in predicting outcomes in cancer patients treated with immunotherapy","volume":"13","author":"Botticelli","year":"2022","journal-title":"Front Immunol"},{"key":"2026072012462740000_bib17","first-page":"15155","article-title":"Association between BRAF and RAS mutations, and RET rearrangements and the clinical features of papillary thyroid cancer","volume":"8","author":"Ming","year":"2015","journal-title":"Int J Clin Exp Pathol"},{"key":"2026072012462740000_bib18","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.1002\/hed.25740","article-title":"Tumor immune microenvironment characteristics of papillary thyroid carcinoma are associated with histopathological aggressiveness and BRAF mutation status","volume":"41","author":"Means","year":"2019","journal-title":"Head Neck"},{"key":"2026072012462740000_bib19","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.1210\/jc.2016-2785","article-title":"TERT, BRAF, and NRAS in primary thyroid cancer and metastatic disease","volume":"102","author":"Melo","year":"2017","journal-title":"J Clin Endocrinol Metab"},{"key":"2026072012462740000_bib20","doi-asserted-by":"crossref","first-page":"4081","DOI":"10.2147\/IJGM.S474827","article-title":"SEMA7A as a novel prognostic biomarker and its correlation with immune infiltrates in breast cancer","volume":"17","author":"Zhang","year":"2024","journal-title":"Int J Gen Med"},{"key":"2026072012462740000_bib21","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/8167496","article-title":"The expression, prognostic value, and immunological correlation of MCEMP1 and its potential role in gastric cancer","volume":"2022","author":"Huang","year":"2022","journal-title":"J Oncol"},{"key":"2026072012462740000_bib22","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1089\/thy.2024.0072","article-title":"Characterization of immune infiltrate along the leading edge of differentiated thyroid cancer","volume":"34","author":"Kotwal","year":"2024","journal-title":"Thyroid"},{"key":"2026072012462740000_bib23","doi-asserted-by":"crossref","first-page":"2876","DOI":"10.1158\/0008-5472.CAN-24-2262","article-title":"Systemic inactivation of TREX1 induces selective inflammation of the tumor microenvironment and invigorated T-cell-mediated tumor control","volume":"85","author":"Marinkovic","year":"2025","journal-title":"Cancer Res"},{"key":"2026072012462740000_bib24","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abo4997","article-title":"Advancing beyond the twists and turns of T cell exhaustion in cancer","volume":"14","author":"van der Heide","year":"2022","journal-title":"Sci Transl Med"},{"key":"2026072012462740000_bib25","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1007\/s12022-023-09769-x","article-title":"Clinical and pathological features and gene expression profiles of clinically aggressive papillary thyroid carcinomas","volume":"34","author":"Metovic","year":"2023","journal-title":"Endocr Pathol"},{"key":"2026072012462740000_bib26","doi-asserted-by":"crossref","first-page":"4761","DOI":"10.1245\/s10434-023-13589-y","article-title":"Diffuse sclerosing papillary thyroid carcinoma: clinicopathological characteristics and prognostic implications compared with classic and tall cell papillary thyroid cancer","volume":"30","author":"Scholfield","year":"2023","journal-title":"Ann Surg Oncol"},{"key":"2026072012462740000_bib27","doi-asserted-by":"crossref","first-page":"2869","DOI":"10.3390\/cancers17172869","article-title":"Histopathological, immunohistochemical, molecular and genetic biomarkers in differentiated thyroid cancer","volume":"17","author":"Al-Abbadi","year":"2025","journal-title":"Cancers"},{"key":"2026072012462740000_bib28","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1097\/MED.0000000000000927","article-title":"The approaches and challenges in the management of differentiated thyroid carcinoma","volume":"32","author":"Blefari","year":"2025","journal-title":"Curr Opin Endocrinol Diabetes Obes"},{"key":"2026072012462740000_bib29","doi-asserted-by":"crossref","DOI":"10.1177\/20420188211049611","article-title":"Medullary thyroid carcinoma: recent advances in identification, treatment, and prognosis","volume":"12","author":"Bartz-Kurycki","year":"2021","journal-title":"Ther Adv Endocrinol Metab"},{"key":"2026072012462740000_bib30","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1053\/j.semdp.2021.10.003","article-title":"Immunohistochemistry as predictive and prognostic markers for gastrointestinal malignancies","volume":"39","author":"Rosenbaum","year":"2022","journal-title":"Semin Diagn Pathol"},{"key":"2026072012462740000_bib31","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1177\/1535370216641787","article-title":"Role of mitochondrial dysfunction in cancer progression","volume":"241","author":"Hsu","year":"2016","journal-title":"Exp Biol Med"},{"key":"2026072012462740000_bib32","doi-asserted-by":"crossref","first-page":"e218","DOI":"10.1002\/mco2.218","article-title":"Metabolic reprogramming in cancer: mechanisms and therapeutics","volume":"4","author":"Nong","year":"2023","journal-title":"MedComm"},{"key":"2026072012462740000_bib33","doi-asserted-by":"crossref","first-page":"6267","DOI":"10.3390\/cancers14246267","article-title":"Lipid metabolism heterogeneity and crosstalk with mitochondria functions drive breast cancer progression and drug resistance","volume":"14","author":"Azam","year":"2022","journal-title":"Cancers"},{"key":"2026072012462740000_bib34","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1158\/1541-7786.MCR-19-0070","article-title":"A Ca(2+)-ATPase regulates E-cadherin biogenesis and epithelial-mesenchymal transition in breast cancer cells","volume":"17","author":"Dang","year":"2019","journal-title":"Mol Cancer Res"},{"key":"2026072012462740000_bib35","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/s41419-025-08331-3","article-title":"HHIPL2 positively governs Hedgehog signaling to accelerate non-small cell lung cancer progression via enhancing HNRNPC-mediated HNF1A mRNA stabilization","volume":"17","author":"Mu","year":"2025","journal-title":"Cell Death Dis"},{"key":"2026072012462740000_bib36","doi-asserted-by":"crossref","first-page":"9618","DOI":"10.18632\/oncotarget.22709","article-title":"Expression of TDRD9 in a subset of lung carcinomas by CpG island hypomethylation protects from DNA damage","volume":"9","author":"Guijo","year":"2018","journal-title":"Oncotarget"},{"key":"2026072012462740000_bib37","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.immuni.2019.06.025","article-title":"Inflammation and cancer: triggers, mechanisms, and consequences","volume":"51","author":"Greten","year":"2019","journal-title":"Immunity"},{"key":"2026072012462740000_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.smim.2025.101997","article-title":"Unlocking IL-18: a hidden key in cancer immunity","volume":"80","author":"Sepehri-Manesh","year":"2025","journal-title":"Semin Immunol"},{"key":"2026072012462740000_bib39","article-title":"IFIT3: a crucial mediator in innate immunity and tumor progression with therapeutic implications","volume":"16","author":"Wu","year":"2025","journal-title":"Front Immunol"},{"key":"2026072012462740000_bib40","doi-asserted-by":"crossref","first-page":"7178","DOI":"10.7150\/thno.43093","article-title":"Inflammatory IFIT3 renders chemotherapy resistance by regulating post-translational modification of VDAC2 in pancreatic cancer","volume":"10","author":"Wang","year":"2020","journal-title":"Theranostics"},{"key":"2026072012462740000_bib41","doi-asserted-by":"crossref","first-page":"202","DOI":"10.3390\/cimb48020202","article-title":"IL-18-Mediated tumor immune evasion","volume":"48","author":"Li","year":"2026","journal-title":"Curr Issues Mol Biol"},{"key":"2026072012462740000_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.107847","article-title":"Extracellular granzyme a promotes colorectal cancer development by enhancing gut inflammation","volume":"32","author":"Santiago","year":"2020","journal-title":"Cell Rep"},{"key":"2026072012462740000_bib43","doi-asserted-by":"crossref","first-page":"6443","DOI":"10.2147\/IJGM.S499872","article-title":"Pan-cancer analysis of the prognostic and immunological role of SEMA7A","volume":"17","author":"Yang","year":"2024","journal-title":"Int J Gen Med"},{"key":"2026072012462740000_bib44","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2021.714053","article-title":"Characterization of the immune cell infiltration landscape of thyroid cancer for improved immunotherapy","volume":"8","author":"Gong","year":"2021","journal-title":"Front Mol Biosci"},{"key":"2026072012462740000_bib45","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/s41419-020-03294-z","article-title":"A new risk factor indicator for papillary thyroid cancer based on immune infiltration","volume":"12","author":"Yang","year":"2021","journal-title":"Cell Death Dis"},{"key":"2026072012462740000_bib46","doi-asserted-by":"crossref","first-page":"7666","DOI":"10.3390\/ijms22147666","article-title":"FOXE1-dependent regulation of macrophage chemotaxis by thyroid cells in vitro and in vivo","volume":"22","author":"Credendino","year":"2021","journal-title":"Int J Mol Sci"},{"key":"2026072012462740000_bib47","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1146\/annurev-immunol-101921-044122","article-title":"Designing cancer immunotherapies that engage T cells and NK cells","volume":"41","author":"Kyrysyuk","year":"2023","journal-title":"Annu Rev Immunol"},{"key":"2026072012462740000_bib48","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1038\/s41419-024-06976-0","article-title":"Natural killer cells at the frontline in the fight against cancer","volume":"15","author":"Co\u00ebnon","year":"2024","journal-title":"Cell Death Dis"},{"key":"2026072012462740000_bib49","article-title":"T cells, NK cells, and tumor-associated macrophages in cancer immunotherapy and the current state of the art of drug delivery systems","volume":"14","author":"Yang","year":"2023","journal-title":"Front Immunol"},{"key":"2026072012462740000_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.113556","article-title":"NK cells propagate T cell immunity following in situ tumor vaccination","volume":"42","author":"Jin","year":"2023","journal-title":"Cell Rep"},{"key":"2026072012462740000_bib51","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1038\/s41423-020-00537-z","article-title":"Correction to: cancer immunotherapy with \u03b3\u03b4 T cells: many paths ahead of us","volume":"17","author":"Kabelitz","year":"2020","journal-title":"Cell Mol Immunol"},{"key":"2026072012462740000_bib52","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.915837","article-title":"Gamma delta T-cell based cancer immunotherapy: past-present-future","volume":"13","author":"Saura-Esteller","year":"2022","journal-title":"Front Immunol"},{"key":"2026072012462740000_bib53","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1084\/jem.169.5.1847","article-title":"Human TCR-gamma+\/delta+, CD8+ T lymphocytes recognize tetanus toxoid in an MHC-restricted fashion","volume":"169","author":"Kozbor","year":"1989","journal-title":"J Exp Med"},{"key":"2026072012462740000_bib54","doi-asserted-by":"crossref","DOI":"10.1080\/2162402X.2017.1347742","article-title":"Distinctive features of tumor-infiltrating \u03b3\u03b4 T lymphocytes in human colorectal cancer","volume":"6","author":"Meraviglia","year":"2017","journal-title":"Oncoimmunology"},{"key":"2026072012462740000_bib55","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.4161\/onci.21659","article-title":"Analysis of V\u03b41 T cells in clinical grade melanoma-infiltrating lymphocytes","volume":"1","author":"Donia","year":"2012","journal-title":"Oncoimmunology"},{"key":"2026072012462740000_bib56","doi-asserted-by":"crossref","DOI":"10.1038\/s41575-026-01196-7","article-title":"\u03b3\u03b4 T cells in colorectal and liver cancer","author":"Kabelitz","year":"2026","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"2026072012462740000_bib57","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1038\/s41571-022-00722-1","article-title":"The emerging roles of \u03b3\u03b4 T cells in cancer immunotherapy","volume":"20","author":"Mensurado","year":"2023","journal-title":"Nat Rev Clin Oncol"},{"key":"2026072012462740000_bib58","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.12441","article-title":"Anti-cancer therapy with TNF\u03b1 and IFN\u03b3: a comprehensive review","volume":"51","author":"Shen","year":"2018","journal-title":"Cell Prolif"},{"key":"2026072012462740000_bib59","doi-asserted-by":"crossref","first-page":"739","DOI":"10.18632\/oncotarget.344","article-title":"Systemic use of tumor necrosis factor alpha as an anticancer agent","volume":"2","author":"Roberts","year":"2011","journal-title":"Oncotarget"},{"key":"2026072012462740000_bib60","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.immuni.2021.01.012","article-title":"Chemokines and the immune response to cancer","volume":"54","author":"Ozga","year":"2021","journal-title":"Immunity"},{"key":"2026072012462740000_bib61","doi-asserted-by":"crossref","first-page":"2998","DOI":"10.1016\/j.celrep.2019.10.120","article-title":"IL-33 signaling alters regulatory T cell diversity in support of tumor development","volume":"29","author":"Li","year":"2019","journal-title":"Cell Rep"},{"key":"2026072012462740000_bib62","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.immuni.2019.01.020","article-title":"Human FOXP3(+) regulatory T cell heterogeneity and function in autoimmunity and cancer","volume":"50","author":"Wing","year":"2019","journal-title":"Immunity"},{"key":"2026072012462740000_bib63","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.biopha.2014.12.008","article-title":"The role of CCL20\/CCR6 axis in recruiting Treg cells to tumor sites of NSCLC patients","volume":"69","author":"Zhang","year":"2015","journal-title":"Biomed Pharmacother"},{"key":"2026072012462740000_bib64","article-title":"In situ prior proliferation of CD4+ CCR6+ regulatory T cells facilitated by TGF-\u03b2 secreting DCs is crucial for their enrichment and suppression in tumor immunity","volume":"6","author":"Xu","year":"2011","journal-title":"PLoS One"},{"key":"2026072012462740000_bib65","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1158\/2326-6066.CIR-20-0312","article-title":"Targeted deletion of CXCR2 in Myeloid cells alters the tumor immune environment to improve antitumor immunity","volume":"9","author":"Yang","year":"2021","journal-title":"Cancer Immunol Res"},{"key":"2026072012462740000_bib66","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.43653","article-title":"CCL5 promotes breast cancer recurrence through macrophage recruitment in residual tumors","volume":"8","author":"Walens","year":"2019","journal-title":"Elife"},{"key":"2026072012462740000_bib67","doi-asserted-by":"crossref","first-page":"2767","DOI":"10.3390\/ijms20112767","article-title":"TGF-\u03b2-Mediated epithelial-mesenchymal transition and cancer metastasis","volume":"20","author":"Hao","year":"2019","journal-title":"Int J Mol Sci"},{"key":"2026072012462740000_bib68","doi-asserted-by":"crossref","first-page":"9107","DOI":"10.1158\/0008-5472.CAN-08-2556","article-title":"Transforming growth factor beta: tumor suppressor or promoter? Are host immune cells the answer?","volume":"68","author":"Yang","year":"2008","journal-title":"Cancer Res"},{"key":"2026072012462740000_bib69","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/s41392-020-00436-9","article-title":"Targeting TGF\u03b2 signal transduction for cancer therapy","volume":"6","author":"Liu","year":"2021","journal-title":"Signal Transduct Target Ther"},{"key":"2026072012462740000_bib70","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.791272","article-title":"Transforming growth factor-beta (TGF-\u03b2) signaling in cancer-A betrayal within","volume":"13","author":"Baba","year":"2022","journal-title":"Front Pharmacol"},{"key":"2026072012462740000_bib71","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1002\/jcb.25496","article-title":"TGF-\u03b2 signaling in cancer","volume":"117","author":"Syed","year":"2016","journal-title":"J Cell Biochem"},{"key":"2026072012462740000_bib72","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1007\/s12672-025-02201-2","article-title":"Integrative analysis of mitochondrial-related gene profiling identifies prognostic clusters and drug resistance mechanisms in low-grade glioma","volume":"16","author":"Chang","year":"2025","journal-title":"Discov Oncol"},{"key":"2026072012462740000_bib73","doi-asserted-by":"crossref","first-page":"3617","DOI":"10.31557\/APJCP.2022.23.11.3617","article-title":"Relationship between the expression of BRAF V600E and Ki-67 with the recurrence of well-differentiated thyroid cancer","volume":"23","author":"Harahap","year":"2022","journal-title":"Asian Pac J Cancer Prev"},{"key":"2026072012462740000_bib74","doi-asserted-by":"crossref","DOI":"10.1177\/11795549231203503","article-title":"Relationships of BRAF V600E gene mutation with some immunohistochemical markers and recurrence rate in patients with thyroid carcinoma","volume":"17","author":"Bui Dang Minh","year":"2023","journal-title":"Clin Med Insights Oncol"},{"key":"2026072012462740000_bib75","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1177\/10507256261417697","article-title":"DDX21 links BRAF(V600E) and TERT to promote thyroid cancer progression","volume":"36","author":"Chen","year":"2026","journal-title":"Thyroid"},{"key":"2026072012462740000_bib76","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1038\/s41586-020-2760-4","article-title":"Structural basis for the action of the drug trametinib at KSR-bound MEK","volume":"588","author":"Khan","year":"2020","journal-title":"Nature"},{"key":"2026072012462740000_bib77","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1158\/1078-0432.CCR-23-0046","article-title":"A phase II redifferentiation trial with Dabrafenib-Trametinib and 131I in metastatic radioactive iodine refractory BRAF p.V600E-Mutated differentiated thyroid cancer","volume":"29","author":"Leboulleux","year":"2023","journal-title":"Clin Cancer Res"},{"key":"2026072012462740000_bib78","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1200\/JCO.22.01000","article-title":"Efficacy and safety of trametinib monotherapy or in combination with dabrafenib in pediatric BRAF V600-mutant low-grade glioma","volume":"41","author":"Bouffet","year":"2023","journal-title":"J Clin Oncol"},{"key":"2026072012462740000_bib79","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.jtho.2021.08.011","article-title":"Phase 2 study of dabrafenib plus trametinib in patients with BRAF V600E-mutant metastatic NSCLC: updated 5-year survival rates and genomic analysis","volume":"17","author":"Planchard","year":"2022","journal-title":"J Thorac Oncol"},{"key":"2026072012462740000_bib80","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.144907","article-title":"SEMA7A: a glycoprotein with therapeutic potential in inflammatory diseases and tumor development","volume":"318","author":"Huang","year":"2025","journal-title":"Int J Biol Macromol"},{"key":"2026072012462740000_bib81","doi-asserted-by":"crossref","DOI":"10.1158\/1535-7163.MCT-25-0675","article-title":"Targeting Semaphorin 7a signaling in preclinical models of endocrine therapy\u2013resistant breast cancer","author":"Steinmetz","year":"2026","journal-title":"Mol Cancer Ther"},{"key":"2026072012462740000_bib82","doi-asserted-by":"crossref","first-page":"445","DOI":"10.7150\/jca.100951","article-title":"NCAPG promotes the malignant progression of endometrioid cancer through LEF1\/SEMA7A\/PI3K-AKT","volume":"16","author":"Ren","year":"2025","journal-title":"J Cancer"},{"key":"2026072012462740000_bib83","doi-asserted-by":"crossref","DOI":"10.1038\/s42003-025-09327-7","article-title":"Sema7a drives an immunosuppressive microenvironment of breast cancer via Kdm4a-mediated DNA replication regulation","volume":"9","author":"Bai","year":"2025","journal-title":"Commun Biol"},{"key":"2026072012462740000_bib84","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2025.117638","article-title":"SEMA7A orchestrates the colorectal cancer tumor microenvironment via PlexinC1: coordinating angiogenesis and macrophage M2 polarization","volume":"245","author":"Zhang","year":"2026","journal-title":"Biochem Pharmacol"},{"key":"2026072012462740000_bib85","article-title":"Tumor-derived SEMA7A regulates fatty acid oxidation in the tumor-associated macrophages to promote the progression of non-small cell lung cancer","volume":"16","author":"Wang","year":"2025","journal-title":"Front Immunol"},{"key":"2026072012462740000_bib86","article-title":"The clinical significance of CD163+ tumor-associated macrophages (TAMs) in laryngeal squamous cell carcinoma","volume":"15","author":"Ouban","year":"2023","journal-title":"Cureus"},{"key":"2026072012462740000_bib87","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/s41586-019-1325-x","article-title":"TOX transcriptionally and epigenetically programs CD8(+) T cell exhaustion","volume":"571","author":"Khan","year":"2019","journal-title":"Nature"},{"key":"2026072012462740000_bib88","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2025.115676","article-title":"Semaphorin7A and PD-L1 cooperatively drive immunosuppression during mammary involution and breast cancer","volume":"44","author":"Elder","year":"2025","journal-title":"Cell Rep"},{"key":"2026072012462740000_bib89","doi-asserted-by":"crossref","first-page":"2772","DOI":"10.1038\/s41388-020-1192-9","article-title":"Postpartum breast cancer progression is driven by semaphorin 7a-mediated invasion and survival","volume":"39","author":"Tarullo","year":"2020","journal-title":"Oncogene"}],"container-title":["Endocrine Connections"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.bioscientifica.com\/ec\/article-pdf\/doi\/10.1530\/EC-26-0245\/521768\/ec-26-0245.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.bioscientifica.com\/ec\/article-pdf\/doi\/10.1530\/EC-26-0245\/521768\/ec-26-0245.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T16:46:46Z","timestamp":1784566006000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.bioscientifica.com\/ec\/article\/15\/7\/e260245\/77772\/Mitochondrial-gene-expression-based-model-for-the"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,1]]},"references-count":89,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7,1]]}},"URL":"https:\/\/doi.org\/10.1530\/ec-26-0245","relation":{},"ISSN":["2049-3614"],"issn-type":[{"value":"2049-3614","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,1]]},"article-number":"e260245"}}