{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T15:06:10Z","timestamp":1789398370350,"version":"build-2803163510"},"reference-count":0,"publisher":"Bioscientifica","license":[{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To comprehensively evaluate the effects of SARS-CoV-2 infection on treated Graves' disease (GD) patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This single-center retrospective cohort study included 220 patients with GD receiving stable antithyroid drug treatment. Among 179 questionnaire respondents, 107 had confirmed SARS-CoV-2 infection and 72 were uninfected. Paired thyroid-function analyses were performed in 65 infected patients, and long COVID was assessed in 72 participants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among the cohort, 107 patients (77.1% female; 69.7% aged &amp;lt;60 years) were infected with SARS-CoV-2. COVID-19 vaccination was less frequent among infected than uninfected participants (70.1% vs 84.7%, P = 0.025). At 12 weeks post-infection, TT3 increased from 1.76 to 1.97 nmol\/L (P = 0.032), whereas TSH, FT3, FT4, TT4, and TRAb remained unchanged. Total cholesterol and HDL-C decreased after infection. TT3 changes differed by vaccination status (P for interaction=0.019), although vaccination was not associated with biochemical thyroid-function deterioration (OR 0.88, 95% CI 0.25\u20133.12). Among 72 participants completing long COVID assessment, 37 (51.4%) met the operational definition; increased hair loss was the most common symptom. Smoking was associated with higher odds of long COVID (OR 5.37, 95% CI 1.05\u201327.36).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>SARS-CoV-2 infection in treated GD patients was associated with modest short-term thyroid and metabolic changes in treated GD patients, while most thyroid indices remained stable. These exploratory findings highlight the need for further prospective studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1530\/ec-26-0616","type":"journal-article","created":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T14:26:41Z","timestamp":1789396001000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-10","source":"Crossref","is-referenced-by-count":0,"title":["Short and Long time Impact of SARS-CoV-2 on clinical characters of Graves' Disease Patients: A Retrospective Cohort Study"],"prefix":"10.1530","author":[{"given":"Bingxin","family":"Li","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine 1 , ,","place":["Shanghai, P.R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiqi","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine 1 , ,","place":["Shanghai, P.R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuwei","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine 1 , ,","place":["Shanghai, P.R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyun","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine 1 , ,","place":["Shanghai, P.R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanfang","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine 1 , ,","place":["Shanghai, P.R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaying","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine 1 , ,","place":["Shanghai, P.R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine 1 , ,","place":["Shanghai, P.R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine 1 , ,","place":["Shanghai, P.R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongde","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine 1 , ,","place":["Shanghai, P.R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Centre for Individualised Infection Medicine (CiiM), a joint venture between the Helmholtz-Centre for Infection Research (HZI) and Hannover Medical School (MHH) 2 . ,","place":["Hannover, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4294-0274","authenticated-orcid":true,"given":"Huanbai","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine 1 , ,","place":["Shanghai, P.R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8641-1550","authenticated-orcid":true,"given":"Ruihua","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine 1 , ,","place":["Shanghai, P.R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","published-online":{"date-parts":[[2026,9,14]]},"container-title":["Endocrine Connections"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.bioscientifica.com\/ec\/article-pdf\/doi\/10.1530\/EC-26-0616\/525270\/ec-26-0616.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.bioscientifica.com\/ec\/article-pdf\/doi\/10.1530\/EC-26-0616\/525270\/ec-26-0616.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T14:26:41Z","timestamp":1789396001000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.bioscientifica.com\/ec\/article\/doi\/10.1530\/EC-26-0616\/78203\/Short-and-Long-time-Impact-of-SARS-CoV-2-on"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,14]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1530\/ec-26-0616","relation":{},"ISSN":["2049-3614"],"issn-type":[{"value":"2049-3614","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,14]]},"article-number":"EC-26-0616"}}