{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:16:44Z","timestamp":1784557004645,"version":"3.55.0"},"reference-count":18,"publisher":"Bioscientifica","content-domain":{"domain":["edm.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2013,8,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Methimazole is an anti-thyroid drug commonly used to treat hyperthyroidism and is a relatively safe medication. Several side effects have been reported and usually develop within 3 months of therapy. Well-known adverse reactions include agranulocytosis, hepatitis, skin eruptions, and musculoskeletal complaints such as myalgia, arthralgia, and arthritis. So far, myositis secondary to carbimazole was described in the context of a lupus-like syndrome or other rare cases of anti-neutrophil cytoplasmic antibodies-associated vasculitis. Methimazole-induced myositis occurring independently of such reactions was rarely stated. We report a patient with hyperthyroidism who, early after therapy with methimazole, developed hepatitis, eosinophilia, and fever that resolved completely after stopping the medication as well as a delayed onset of biopsy-proven eosinophilic myositis and fasciitis of gluteal muscles that resolved eventually without any additional therapy. Therefore, we raise the awareness regarding a rare side effect of methimazole: myositis.<\/jats:p>\n                  <jats:sec>\n                    <jats:title>Learning points<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Several differential diagnoses arise when managing a hyperthyroid patient with muscle complaints.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Both hyperthyroidism and methimazole are associated with myositis.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Methimazole-induced myositis is a rare clinical entity.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Resolution of symptoms may occur after stopping methimazole.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1530\/edm-13-0008","type":"journal-article","created":{"date-parts":[[2013,8,30]],"date-time":"2013-08-30T06:46:19Z","timestamp":1377845179000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-2","source":"Crossref","is-referenced-by-count":3,"title":["Methimazole-induced myositis: a case report and review of the literature"],"prefix":"10.1530","volume":"2013","author":[{"given":"R","family":"Bou Khalil","sequence":"first","affiliation":[{"name":"1 Departments of Endocrinology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Abou Salbi","sequence":"additional","affiliation":[{"name":"2 Family Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Sissi","sequence":"additional","affiliation":[{"name":"1 Departments of Endocrinology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"El Kara","sequence":"additional","affiliation":[{"name":"3 Infectious Diseases"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Azar","sequence":"additional","affiliation":[{"name":"3 Infectious Diseases"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Khoury","sequence":"additional","affiliation":[{"name":"4 General Surgery"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Abdallah","sequence":"additional","affiliation":[{"name":"2 Family Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Hreiki","sequence":"additional","affiliation":[{"name":"5 Pathology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Farhat","sequence":"additional","affiliation":[{"name":"6 Gastroenterology, Saint Georges University Medical Center, University of Balamand, Beirut, Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"ref161","article-title":"Carbimazole-induced lupus","year":"2008","journal-title":"BMJ Case Reports"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0307-742X(21)00490-2","article-title":"Less common causes of myositis","volume":"10","year":"1984","journal-title":"Clinics in Rheumatic Diseases"},{"key":"ref91","first-page":"340","article-title":"Polymyositis after propylthiouracil treatment for hyperthyroidism","volume":"47","year":"2013","journal-title":"Annals of Rheumatic Disease"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1046\/j.1468-1331.2003.00481.x","article-title":"Eosinophilic major basic protein and interleukin-5 in eosinophilic myositis","volume":"10","year":"2003","journal-title":"European Journal of Neurology"},{"key":"ref81","first-page":"801","article-title":"Carbimazole induced ANCA positive vasculitis","volume":"56","journal-title":"Journal of Association of Physicians of India"},{"key":"ref151","first-page":"278","article-title":"Methimazole-induced lupus erythematous: a case report","volume":"36","year":"2003","journal-title":"Journal of Microbiology, Immunology, and Infection"},{"key":"ref171","first-page":"801","article-title":"Carbimazole induced ANCA positive vasculitis","volume":"56","journal-title":"Journal of Association of Physicians of India"},{"key":"ref31","first-page":"581","article-title":"Idiopathic eosinophilic myositis","volume":"88","year":"1995","journal-title":"QJM: Monthly Journal of the Association of Physicians"},{"key":"ref41","first-page":"241","article-title":"Elevation of creatine kinase during medical treatment of Graves's disease","volume":"27","year":"2007","journal-title":"Journal of Medical Sciences"},{"key":"ref101","first-page":"179","article-title":"Carbimazole-related myositis in a Chinese woman","volume":"28","year":"2006","journal-title":"Hong Kong Practitioner"},{"key":"ref01","first-page":"340","article-title":"Polymyositis after propylthiouracil treatment for hyperthyroidism","volume":"47","year":"2013","journal-title":"Annals of Rheumatic Disease"},{"key":"ref111","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0307-742X(21)00490-2","article-title":"Less common causes of myositis","volume":"10","year":"1984","journal-title":"Clinics in Rheumatic Diseases"},{"key":"ref131","first-page":"241","article-title":"Elevation of creatine kinase during medical treatment of Graves's disease","volume":"27","year":"2007","journal-title":"Journal of Medical Sciences"},{"key":"ref71","article-title":"Carbimazole-induced lupus","year":"2008","journal-title":"BMJ Case Reports"},{"key":"ref121","first-page":"581","article-title":"Idiopathic eosinophilic myositis","volume":"88","year":"1995","journal-title":"QJM: Monthly Journal of the Association of Physicians"},{"key":"ref11","first-page":"179","article-title":"Carbimazole-related myositis in a Chinese woman","volume":"28","year":"2006","journal-title":"Hong Kong Practitioner"},{"key":"ref141","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1046\/j.1468-1331.2003.00481.x","article-title":"Eosinophilic major basic protein and interleukin-5 in eosinophilic myositis","volume":"10","year":"2003","journal-title":"European Journal of Neurology"},{"key":"ref61","first-page":"278","article-title":"Methimazole-induced lupus erythematous: a case report","volume":"36","year":"2003","journal-title":"Journal of Microbiology, Immunology, and Infection"}],"container-title":["Endocrinology, Diabetes &amp; Metabolism Case 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