{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:17:21Z","timestamp":1784557041044,"version":"3.55.0"},"reference-count":14,"publisher":"Bioscientifica","content-domain":{"domain":["edm.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2013,9,1]]},"abstract":"Summary<\/jats:title>\n Ectopic secretion of ACTH is an infrequent cause of Cushing's syndrome. We report a case of ectopic ACTH syndrome caused by a nasal paraganglioma, a 68-year-old female with clinical features of Cushing's syndrome, serious hypokalaemia and a right paranasal sinus' lesion. Cranial magnetic resonance image showed a 46-mm mass on the right paranasal sinuses. Endocrinological investigation confirmed the diagnosis of ectopic ACTH production. Resection of the tumour normalised ACTH and cortisol secretion. The tumour was found to be a paraganglioma through microscopic analysis. On follow-up 3 months later, the patient showed nearly complete clinical recovery. Ectopic ACTH syndrome due to nasal paraganglioma is extremely uncommon, as only two other cases have been discussed in the literature.<\/jats:p>\n \n Learning points<\/jats:title>\n \n \n \n Ectopic Cushing's syndrome accounts for 10% of Cushing's syndrome etiologies.<\/jats:p>\n <\/jats:list-item>\n \n Most paraganglioma of the head and neck are not hormonally active.<\/jats:p>\n <\/jats:list-item>\n \n Nasal paraganglioma, especially ACTH producing, is a very rare tumour.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1530\/edm-13-0038","type":"journal-article","created":{"date-parts":[[2013,9,16]],"date-time":"2013-09-16T06:49:50Z","timestamp":1379314190000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-2","source":"Crossref","is-referenced-by-count":3,"title":["Cushing's syndrome due to ectopic ACTH production by a nasal paraganglioma"],"prefix":"10.1530","volume":"2013","author":[{"given":"F","family":"Serra","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Hospital Egas Moniz, Centro Hospitalar Lisboa Ocidental, Lisbon, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Duarte","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Hospital Egas Moniz, Centro Hospitalar Lisboa Ocidental, Lisbon, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Abreu","sequence":"additional","affiliation":[{"name":"1 Department of Endocrinology, Hospital Central do Funchal, Funchal, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Marques","sequence":"additional","affiliation":[{"name":"2 Departments of Neurosurgery"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Cassis","sequence":"additional","affiliation":[{"name":"3 Pathology, 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