{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:17:28Z","timestamp":1784557048006,"version":"3.55.0"},"reference-count":20,"publisher":"Bioscientifica","content-domain":{"domain":["edm.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2014,1,1]]},"abstract":"Summary<\/jats:title>\n Glycogen storage disease (GSD) type I is characterized by impaired production of glucose from glycogenolysis and gluconeogenesis resulting in severe hypoglycaemia and increased production of lactic acid, triglyceride and uric acid. The most common type, glycogenosis type Ia, demands a balanced, sufficient carbohydrate intake to preserve normal 24-h glycaemia. Insufficient intake of carbohydrates can cause hypoglycaemia, as the missing glucose-6-phosphatase enzyme cannot free the glucose stored as liver glycogen and nor is gluconeogenesis possible. The principle means of handling this disorder is to avoid starving by taking regular meals during the day and night. Such a dietary regimen could lead to obesity. Herein, we present the case of an adult patient with glycogenosis type Ia suffering from hyperuricaemia, dyslipidaemia and arterial hypertension. The accumulation of these cardiovascular risk factors could lead to the early onset of atherosclerosis, which should be postponed by contemporary methods of surveillance and treatment.<\/jats:p>\n \n Learning points<\/jats:title>\n \n \n \n Continuous subcutaneous glucose monitoring may be of value in every adult patient with GSD type I to evaluate the actual prevalence of eventual hypoglycaemic and hyperglycaemic episodes.<\/jats:p>\n <\/jats:list-item>\n \n Good dietary management minimizes the metabolic abnormalities of the disease and decreases the risk of long-term complications.<\/jats:p>\n <\/jats:list-item>\n \n Treatment of obesity in patients with GSD reduces the risk of earlier atherosclerosis and cardiovascular disease.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1530\/edm-13-0056","type":"journal-article","created":{"date-parts":[[2014,1,17]],"date-time":"2014-01-17T09:45:16Z","timestamp":1389951916000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-2","source":"Crossref","is-referenced-by-count":1,"title":["Continuous glucose monitoring in the treatment of obesity in patients with glycogen storage disease type Ia"],"prefix":"10.1530","volume":"2014","author":[{"given":"Betty Korljan","family":"Jelaska","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, University Hospital Split, Split, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanja Bar\u0161i\u0107","family":"Ostoji\u0107","sequence":"additional","affiliation":[{"name":"1Department of Radiology, General Hospital Sveti Duh, Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Berovi\u0107","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University Hospital Split, Split, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vi\u0161nja","family":"Koki\u0107","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University Hospital Split, Split, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"ref91","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1023\/A:1005605513534","article-title":"Apolipoprotein E polymorphism and serum concentrations in patients with glycogen storage disease type Ia","volume":"23","year":"2000","journal-title":"Journal of Inherited Metabolic Disease"},{"key":"ref131","first-page":"277","article-title":"RebrinKSteilGMvan MastrototaroJJSubcutaneous glucose predicts plasma glucose independent of insulin : implications for continuous monitoring of","author":"AntwerpWP","journal-title":"American Journal Physiology"},{"key":"ref191","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1023\/A:1005605513534","article-title":"Apolipoprotein E polymorphism and serum concentrations in patients with glycogen storage disease type Ia","volume":"23","year":"2000","journal-title":"Journal of Inherited Metabolic Disease"},{"key":"ref51","article-title":"AS s Principles of Internal th New York Publications","author":"Longo","year":"2012","journal-title":"Medicine edn"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1111\/j.1440-1754.2006.00973.x","article-title":"Unrecognised hypoglycaemia in children and adolescents with type 1 diabetes using the continuous glucose monitoring system: prevalence and contributors","volume":"42","year":"2006","journal-title":"Journal of Paediatrics and Child Health"},{"key":"ref161","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1023\/A:1013996325720","article-title":"Continuous glucose monitoring in children with glycogen storage disease type I","volume":"24","journal-title":"Journal of Inherited Metabolic Disease"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"12000","DOI":"10.1089\/15209150050214087","article-title":"Efficacy and reliability of the continuous glucose monitoring system","author":"GrossTM","year":"2001","journal-title":"Diabetes Technology Therapeutics"},{"key":"ref01","first-page":"801","article-title":"Glycogen storage diseases. 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