{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:13:26Z","timestamp":1787022806765,"version":"build-2736575974"},"reference-count":34,"publisher":"Bioscientifica","content-domain":{"domain":["edm.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2014,2,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    A 30-year-old female presented with a history of secondary amenorrhoea, acromegalic features and progressive visual deterioration. She had elevated serum IGF1 levels and unsuppressed GH levels after an oral glucose tolerance test. Magnetic resonance imaging revealed a heterogeneously enhancing space-occupying lesion with atypical extensive calcification within the sellar and suprasellar areas. Owing to the extent of calcification, the tumour was a surgical challenge. Postoperatively, there was clinical, radiological and biochemical evidence of residual disease, which required treatment with a somatostatin analogue and radiotherapy. Mutational analysis of the aryl hydrocarbon receptor-interacting protein (\n                    <jats:italic>AIP<\/jats:italic>\n                    ) gene was negative. This case confirms the relatively rare occurrence of calcification within a pituitary macroadenoma and its associated management problems. The presentation, biochemical, radiological and pathological findings are discussed in the context of the relevant literature.\n                  <\/jats:p>\n                  <jats:sec>\n                    <jats:title>Learning points<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Calcification of pituitary tumours is relatively rare.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Recognising calcification in pituitary adenomas on preoperative imaging is important in surgical decision-making.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Gross total resection can be difficult to achieve in the presence of extensive calcification and dictates further management and follow-up to achieve disease control.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1530\/edm-13-0079","type":"journal-article","created":{"date-parts":[[2014,2,11]],"date-time":"2014-02-11T06:01:43Z","timestamp":1392098503000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-2","source":"Crossref","is-referenced-by-count":6,"title":["Dense calcification in a GH-secreting pituitary macroadenoma"],"prefix":"10.1530","volume":"2014","author":[{"given":"Ramez","family":"Ibrahim","sequence":"first","affiliation":[{"name":"Royal Hallamshire Hospital, Sheffield, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atul","family":"Kalhan","sequence":"additional","affiliation":[{"name":"1University Hospital of Wales, Cardiff, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alistair","family":"Lammie","sequence":"additional","affiliation":[{"name":"2Cardiff University, Cardiff, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Kotonya","sequence":"additional","affiliation":[{"name":"3Bronglais Hospital, Aberystwyth, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravindra","family":"Nannapanenni","sequence":"additional","affiliation":[{"name":"1University Hospital of Wales, Cardiff, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aled","family":"Rees","sequence":"additional","affiliation":[{"name":"4Institute of Molecular and Experimental Medicine, Cardiff University, Cardiff, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"ref221","doi-asserted-by":"crossref","first-page":"729","DOI":"10.2176\/nmc.36.729","article-title":"Total capsular calcification in a prolactinoma \u2013 case report","volume":"36","year":"1996","journal-title":"Neurologia Medico-Chirurgica"},{"key":"ref251","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/0002-9343(80)90229-6","article-title":"Characterization of a pituitary stone","volume":"68","year":"1980","journal-title":"American Journal of Medicine"},{"key":"ref101","first-page":"205","article-title":"Osseous metaplasia in a growth hormone-secreting pituitary adenoma","volume":"18","year":"1999","journal-title":"Clinical Neuropathology"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0090-3019(81)80003-1","article-title":"Calcifications in pituitary adenomas","volume":"15","year":"1981","journal-title":"Surgical Neurology"},{"key":"ref241","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1227\/00006123-198703000-00021","article-title":"Ossified prolactinoma: case report","volume":"20","year":"1987","journal-title":"Neurosurgery"},{"key":"ref01","first-page":"22","article-title":"Pituitary adenoma calcification","volume":"101","year":"1977","journal-title":"Archives of Pathology & Laboratory Medicine"},{"key":"ref321","first-page":"232","article-title":"A rare case of pituitary adenoma with calcification: a case report","volume":"18","year":"2008","journal-title":"Turkish Neurosurgery"},{"key":"ref281","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/j.1365-2265.1994.tb02456.x","article-title":"Pituitary stone: two cases of densely calcified thyrotrophin-secreting pituitary adenomas","volume":"40","year":"1994","journal-title":"Clinical Endocrinology"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0090-3019(94)90112-0","article-title":"Ossified somatotropinoma","volume":"41","year":"1994","journal-title":"Surgical Neurology"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"871","DOI":"10.3171\/jns.1983.59.5.0871","article-title":"Calcified pituitary adenoma associated with severe hyperprolactinemia. 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