{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:16:37Z","timestamp":1784556997999,"version":"3.55.0"},"reference-count":22,"publisher":"Bioscientifica","content-domain":{"domain":["edm.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2014,3,1]]},"abstract":"Summary<\/jats:title>\n \n ACTH-dependent Cushing's syndrome includes Cushing's disease and ectopic ACTH syndrome (EAS). The differential diagnosis of Cushing's disease from EAS in cases of ACTH-dependent Cushing's syndrome is a challenging problem. We report here a case of EAS with an unknown source of ACTH secretion. Extensive imaging procedures, involving computed tomography (neck to pelvis), pituitary magnetic resonance imaging, and whole-body\n 18<\/jats:sup>\n F-fluorodeoxyglucose-positron emission tomography, failed to reveal the source of ACTH secretion. Intermittent administration of bromocriptine, a short-acting and nonselective dopamine agonist, has afforded adequate suppression of plasma ACTH and cortisol levels over the long term.\n <\/jats:p>\n \n Learning points<\/jats:title>\n \n \n \n Tumor excision is the primary treatment for EAS. However, when surgery is impossible, medical therapy is needed to treat hypercortisolism.<\/jats:p>\n <\/jats:list-item>\n \n In cases where the source of ACTH secretion is unknown, inhibitors of steroidogenesis, such as metyrapone, mitotane, ketoconazole, and etomidate, are mostly used to suppress cortisol secretion.<\/jats:p>\n <\/jats:list-item>\n \n Medications that suppress ACTH secretion are less effective, therefore less popular, as standard treatments.<\/jats:p>\n <\/jats:list-item>\n \n In the present case, short-term treatment with dopamine agonists was effective for the long-term suppression of both ACTH and cortisol levels.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1530\/edm-14-0001","type":"journal-article","created":{"date-parts":[[2014,3,15]],"date-time":"2014-03-15T04:03:55Z","timestamp":1394856235000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-2","source":"Crossref","is-referenced-by-count":1,"title":["A case of ectopic ACTH syndrome treated with intermittent administration of dopamine 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