{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:16:45Z","timestamp":1784557005637,"version":"3.55.0"},"reference-count":22,"publisher":"Bioscientifica","content-domain":{"domain":["edm.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2014,7,1]]},"abstract":"Summary<\/jats:title>\n A 55-year-old male, with a positive medical history for hypothyroidism, treated with stable doses for years was admitted with subacute thyroiditis and a feeling of pain and pressure in the neck. Laboratory tests showed decrease in TSH levels, elevated erythrocyte sedimentation rate, and very high antithyroid antibodies. Owing to enlarging goiter and exacerbation in the patient's complaints, he was operated with excision of a fibrotic and enlarged thyroid lobe. Elevated IgG4 plasma levels and high IgG4\/IgG plasma cell ratio on immunohistochemistry led to the diagnosis of IgG4-mediated thyroiditis. We concluded that IgG4-thyroiditis and IgG4-related disease should be considered in all patients with an aggressive form of Hashimoto's thyroiditis.<\/jats:p>\n \n Learning points<\/jats:title>\n \n \n \n IgG4-related disease is a systemic disease that includes several syndromes; IgG4-related thyroiditis is one among them.<\/jats:p>\n <\/jats:list-item>\n \n IgG4-thyroiditis should be considered in all patients with an aggressive form of Hashimoto's thyroiditis.<\/jats:p>\n <\/jats:list-item>\n \n Patients with suspected IgG4-thyroiditis should have blood tested for IgG4\/IgG ratio and appropriate immunohistochemical staining if possible.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1530\/edm-14-0037","type":"journal-article","created":{"date-parts":[[2014,7,22]],"date-time":"2014-07-22T05:47:15Z","timestamp":1406008035000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-2","source":"Crossref","is-referenced-by-count":1,"title":["IgG4-related thyroiditis: a case report and review of literature"],"prefix":"10.1530","volume":"2014","author":[{"given":"Mahmud","family":"Abo Salook","sequence":"first","affiliation":[{"name":"1 Endocrine Institute"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Benbassat","sequence":"additional","affiliation":[{"name":"1 Endocrine Institute"},{"name":"3 Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulia","family":"Strenov","sequence":"additional","affiliation":[{"name":"2 Pathology Laboratory, Rabin Medical Center, Beilinson Campus, Petah Tiqva 49100, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Tirosh","sequence":"additional","affiliation":[{"name":"1 Endocrine Institute"},{"name":"3 Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"ref181","doi-asserted-by":"crossref","first-page":"529","DOI":"10.2169\/internalmedicine.49.3038","article-title":"Metachronous extrapancreatic lesions in autoimmune pancreatitis","volume":"49","year":"2010","journal-title":"Internal Medicine"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/MPA.0b013e3181bd64a1","article-title":"Clinical significance of extrapancreatic lesions in autoimmune pancreatitis","volume":"39","year":"2010","journal-title":"Pancreas"},{"key":"ref131","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3109\/s10165-011-0571-z","article-title":"Comprehensive diagnostic criteria for IgG4-related disease (IgG4-RD), 2011","volume":"22","year":"2012","journal-title":"Modern Rheumatology"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1089\/thy.2011.0404","article-title":"Riedel's thyroiditis with increased IgG4 plasma cells: evidence for an underlying IgG4-related sclerosing disease?","volume":"22","year":"2012","journal-title":"Thyroid"},{"key":"ref201","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1002\/acr.20215","article-title":"Riedel's thyroiditis and multifocal fibrosclerosis are part of the IgG4-related systemic disease spectrum","volume":"62","year":"2010","journal-title":"Arthritis Care & Research"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1007\/s00535-003-1175-y","article-title":"A new clinicopathological entity of IgG4-related autoimmune disease","volume":"38","year":"2003","journal-title":"Journal of Gastroenterology"},{"key":"ref191","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1089\/thy.2011.0404","article-title":"Riedel's thyroiditis with increased IgG4 plasma cells: evidence for an underlying IgG4-related sclerosing disease?","volume":"22","year":"2012","journal-title":"Thyroid"},{"key":"ref141","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/MPA.0b013e3181bd64a1","article-title":"Clinical significance of extrapancreatic lesions in autoimmune pancreatitis","volume":"39","year":"2010","journal-title":"Pancreas"},{"key":"ref151","first-page":"1197","article-title":"Prevalence and distribution of extrapancreatic lesions complicating autoimmune pancreatitis","volume":"41","year":"2006","journal-title":"Journal of Gastroenterology"},{"key":"ref41","first-page":"1197","article-title":"Prevalence and distribution of extrapancreatic lesions complicating autoimmune pancreatitis","volume":"41","year":"2006","journal-title":"Journal of Gastroenterology"},{"key":"ref171","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1136\/ard.2008.089169","article-title":"Proposal for a new clinical entity, IgG4-positive multiorgan lymphoproliferative syndrome: analysis of 64 cases of IgG4-related disorders","volume":"68","year":"2009","journal-title":"Annals of the Rheumatic Diseases"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1136\/ard.2008.089169","article-title":"Proposal for a new clinical entity, IgG4-positive multiorgan lymphoproliferative syndrome: analysis of 64 cases of IgG4-related disorders","volume":"68","year":"2009","journal-title":"Annals of the Rheumatic Diseases"},{"key":"ref01","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1056\/NEJM200103083441005","article-title":"High serum IgG4 concentrations in patients with sclerosing pancreatitis","volume":"344","year":"2001","journal-title":"New England Journal of Medicine"},{"key":"ref211","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1210\/jc.2009-1794","article-title":"Distinct clinical, serological, and sonographic characteristics of Hashimoto's thyroiditis based with and without IgG4-positive plasma cells","volume":"95","year":"2010","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1097\/00000478-200308000-00009","article-title":"Idiopathic chronic pancreatitis with periductal lymphoplasmacytic infiltration. Clinicopathological features of 35 cases","volume":"27","year":"2003","journal-title":"American Journal of Surgical Pathology"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"529","DOI":"10.2169\/internalmedicine.49.3038","article-title":"Metachronous extrapancreatic lesions in autoimmune pancreatitis","volume":"49","year":"2010","journal-title":"Internal Medicine"},{"key":"ref101","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1210\/jc.2009-1794","article-title":"Distinct clinical, serological, and sonographic characteristics of Hashimoto's thyroiditis based with and without IgG4-positive plasma cells","volume":"95","year":"2010","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref111","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1056\/NEJM200103083441005","article-title":"High serum IgG4 concentrations in patients with sclerosing pancreatitis","volume":"344","year":"2001","journal-title":"New England Journal of Medicine"},{"key":"ref161","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1097\/00000478-200308000-00009","article-title":"Idiopathic chronic pancreatitis with periductal lymphoplasmacytic infiltration. Clinicopathological features of 35 cases","volume":"27","year":"2003","journal-title":"American Journal of Surgical Pathology"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1002\/acr.20215","article-title":"Riedel's thyroiditis and multifocal fibrosclerosis are part of the IgG4-related systemic disease spectrum","volume":"62","year":"2010","journal-title":"Arthritis Care & Research"},{"key":"ref121","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1007\/s00535-003-1175-y","article-title":"A new clinicopathological entity of IgG4-related autoimmune disease","volume":"38","year":"2003","journal-title":"Journal of Gastroenterology"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3109\/s10165-011-0571-z","article-title":"Comprehensive diagnostic criteria for IgG4-related disease (IgG4-RD), 2011","volume":"22","year":"2012","journal-title":"Modern Rheumatology"}],"container-title":["Endocrinology, Diabetes & Metabolism Case Reports"],"original-title":[],"link":[{"URL":"https:\/\/edm.bioscientifica.com\/view\/journals\/edm\/2014\/1\/EDM14-0037.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/edm.bioscientifica.com\/downloadpdf\/journals\/edm\/2014\/1\/EDM14-0037.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:45:56Z","timestamp":1784555156000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.bioscientifica.com\/edm\/article\/3233"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,1]]},"references-count":22,"URL":"https:\/\/doi.org\/10.1530\/edm-14-0037","relation":{},"ISSN":["2052-0573"],"issn-type":[{"value":"2052-0573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,1]]}}}