{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T10:51:52Z","timestamp":1790247112128,"version":"4.1.0"},"reference-count":24,"publisher":"Bioscientifica","content-domain":{"domain":["edm.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2014,7,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>A 48-year-old hypertensive and diabetic patient presented with a 10-year history of progressive right facial pain, tinnitus, hearing loss, sweating, and palpitations. Investigations revealed a 5.6\u200acm vascular tumor at the carotid bifurcation. Her blood pressure (BP) was 170\/110, on lisinopril 20\u200amg od and amlodipine 10\u200amg od and 100\u200aU of insulin daily. A catecholamine-secreting carotid body paraganglioma (CSCBP) was suspected; the diagnosis was confirmed biochemically by determining plasma norepinephrine (NE) level, 89\u200a000\u200apmol\/l, and chromogranin A (CgA) level, 279\u200a\u03bcg\/l. Meta-iodobenzylguanidine and octreotide scanning confirmed a single tumor in the neck. A week after giving the patient a trial of octreotide 100\u200a\u03bcg 8\u200ah, the NE level dropped progressively from 50\u200a000 to 25\u200a000\u200apmol\/l and CgA from 279 to 25\u200a\u03bcg\/l. Treatment was therefore continued with labetalol 200\u200amg twice daily (bid) and long-acting octreotide-LA initially using 40\u200amg\/month and later increasing to 80\u200amg\/month. On this dose and with a reduced labetalol intake of 100\u200amg bid, BP was maintained at 130\/70 and her symptoms resolved completely. CgA levels returned to normal in the first week and these were maintained throughout the 3 month treatment period. During tumor resection, there were minimal BP fluctuations during the 10\u200ah procedure. We conclude that short-term high-dose octreotide-LA might prove valuable in the preoperative management of catecholamine-secreting tumors. To the best of our knowledge, this is the first report on the successful use of octreotide in a CSCBP.<\/jats:p>\n                  <jats:sec>\n                    <jats:title>Learning points<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>The value of octreotide scanning in the localization of extra-adrenal pheochromocytoma.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Control of catecholamine secretion using high-dose octreotide.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>This is a report of a rare cause of secondary diabetes and hypertension.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  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