{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:17:23Z","timestamp":1784557043880,"version":"3.55.0"},"reference-count":28,"publisher":"Bioscientifica","content-domain":{"domain":["edm.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2015,1,1]]},"abstract":"Summary<\/jats:title>\n A 54-year-old woman presented with bi-temporal hemianopia, palpitations, and diaphoresis. An invasive pituitary macroadenoma was discovered. The patient had biochemical evidence of secondary hyperthyroidism and GH excess; however, she did not appear to be acromegalic. Surgical removal of the pituitary mass revealed a plurihormonal TSH\/GH co-secreting pituitary adenoma. TSH-secreting adenomas can co-secrete other hormones including GH, prolactin, and gonadotropins; conversely, co-secretion of TSH from a pituitary adenoma in acromegaly is infrequent.<\/jats:p>\n \n Learning points<\/jats:title>\n \n \n \n This case highlights an unusual patient with a rare TSH\/GH co-secreting pituitary adenoma with absence of the clinical features of acromegaly.<\/jats:p>\n <\/jats:list-item>\n \n Plurihormonality does not always translate into the clinical features of hormonal excess.<\/jats:p>\n <\/jats:list-item>\n \n There appears to be a clinical and immunohistochemical spectrum present in plurihormonal tumors.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n 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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A","family":"Prayson","sequence":"additional","affiliation":[{"name":"1 Patholgy and Laboratory Medicine Institute, Rose Ella Burkhardt Brain Tumor and Neuro-Oncology Center, Cleveland Clinic, Cleveland, Ohio 44195, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Kennedy","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetes and Metabolism, Cleveland Clinic Foundation, 9500 Euclid Avenue Desk F20, Cleveland, Ohio 44195, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J","family":"Weil","sequence":"additional","affiliation":[{"name":"2 Department of Neurosurgery and the Neurological Institute, Rose Ella Burkhardt Brain Tumor and Neuro-Oncology Center, Cleveland Clinic, Cleveland, Ohio 44195, 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