{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:17:11Z","timestamp":1784557031536,"version":"3.55.0"},"reference-count":26,"publisher":"Bioscientifica","content-domain":{"domain":["edm.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2015,2,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>A case of recurrent pituitary apoplexy is described in a 72-year-old man who initially presented with haemorrhage in a non-functioning pituitary adenoma. Five years later, he re-presented with a severe pituitary haemorrhage in an enlarging sellar mass invading both cavernous sinuses causing epistaxis and bilateral ocular paresis. Subsequent histology was consistent with a sellar malignant spindle and round cell neoplasm. Multiple pituitary tumours have previously been reported to coexist in the same individual, but to our knowledge this is the only case where two pathologically distinct pituitary neoplasms have sequentially arisen in a single patient. This case is also notable with respect to the progressive ocular paresis, including bilateral abducens nerve palsies, and the presentation with epistaxis.<\/jats:p>\n                  <jats:sec>\n                    <jats:title>Learning points<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Ocular paresis in pituitary apoplexy can result from tumour infiltration of nerves, or by indirect compression via increased intrasellar pressure.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Epistaxis is a very rare presentation of a pituitary lesion.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Epistaxis more commonly occurs following trans-sphenoidal surgery, and can be delayed.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1530\/edm-14-0088","type":"journal-article","created":{"date-parts":[[2015,2,10]],"date-time":"2015-02-10T05:17:02Z","timestamp":1423545422000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-2","source":"Crossref","is-referenced-by-count":2,"title":["Recurrent pituitary apoplexy due to two successive neoplasms presenting with ocular paresis and epistaxis"],"prefix":"10.1530","volume":"2015","author":[{"given":"Stephanie","family":"Teasdale","sequence":"first","affiliation":[{"name":"1 Department of Diabetes and Endocrinology, Princess Alexandra Hospital, Brisbane, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fahid","family":"Hashem","sequence":"additional","affiliation":[{"name":"1 Department of Diabetes and Endocrinology, Princess Alexandra Hospital, Brisbane, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Olson","sequence":"additional","affiliation":[{"name":"2 Department of Neurosurgery, Princess Alexandra Hospital, Brisbane, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Ong","sequence":"additional","affiliation":[{"name":"3 Department of Radiology, Princess Alexandra Hospital, Brisbane, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Warrick J","family":"Inder","sequence":"additional","affiliation":[{"name":"1 Department of Diabetes and Endocrinology, Princess Alexandra Hospital, Brisbane, Queensland, Australia"},{"name":"4 School of Medicine, The University of Queensland, Brisbane, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"ref51","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1001\/archopht.1949.00900050656014","article-title":"Bilateral total ophthalmoplegia with adenoma of the pituitary gland; 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