{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:17:22Z","timestamp":1784557042498,"version":"3.55.0"},"reference-count":42,"publisher":"Bioscientifica","content-domain":{"domain":["edm.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2015,1,1]]},"abstract":"Summary<\/jats:title>\n Xanthogranulomatous hypophysitis (XGH) is a very rare form of pituitary hypophysitis that may present both clinically and radiologically as a neoplastic lesion. It may either be primary with an autoimmune aetiology and can occur in isolation or as a part of autoimmune systemic disease or secondary as a reactive degenerative response to an epithelial lesion (e.g. craniopharyngioma (CP), Rathke's cleft cyst, germinoma and pituitary adenomas) or as a part of a multiorgan systemic involvement such as tuberculosis, sarcoidosis or granulomatosis. It may also present with a variation of symptoms in children and adults. Our case series compares the paediatric and adult presentations of XGH and the differential diagnoses considered in one child and two adult patients, highlighting the wide spectrum of this condition. Endocrine investigations suggested panhypopituitarism in all three patients and imaging revealed a suprasellar mass compressing the optic chiasm suggestive of CP or Rathke's cleft cyst in one patient and non-functioning pituitary macroadenoma in two patients. Magnetic resonance imaging (MRI) demonstrated mixed signal intensities on T1- and T2-weighted sequences. Following endoscopic transsphenoidal surgery, histological analysis revealed necrotic material with a xanthogranulomatous reaction confirming XGH in two patients and a necrobiotic granulomatous chronic inflammatory infiltrate with neutrophils in one patient, which is not typical of current descriptions of this disorder. This case series describes the wide spectrum of XGH disease that is yet to be defined. Mixed signal intensities on T1- and T2-weighted MRI sequences may indicate XGH and diagnosis is confirmed by histology. Histological variation may indicate an underlying systemic process.<\/jats:p>\n \n Learning points<\/jats:title>\n \n \n \n XGH is a rare form of pituitary hypophysitis with a wide clinical and histological spectrum and can mimic a neoplastic lesion.<\/jats:p>\n <\/jats:list-item>\n \n XGH primarily presents with growth arrest in children and pubertal arrest in adolescents. In adults, the presentation may vary.<\/jats:p>\n <\/jats:list-item>\n \n A combination of hypopituitarism and mixed signal intensity lesion on MRI is suggestive of XGH and should be considered in the differential diagnosis of sellar lesions.<\/jats:p>\n <\/jats:list-item>\n \n Radical surgery is the treatment of choice and carries an excellent prognosis with no recurrence.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1530\/edm-14-0089","type":"journal-article","created":{"date-parts":[[2015,2,20]],"date-time":"2015-02-20T05:53:12Z","timestamp":1424411592000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-2","source":"Crossref","is-referenced-by-count":5,"title":["Xanthogranulomatous hypophysitis: a rare and often mistaken pituitary lesion"],"prefix":"10.1530","volume":"2015","author":[{"given":"Jaya Sujatha","family":"Gopal-Kothandapani","sequence":"first","affiliation":[{"name":"Department of Human Metabolism, University of Sheffield, Sheffield, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veejay","family":"Bagga","sequence":"additional","affiliation":[{"name":"1 Department of Neurosurgery, Royal Hallamshire Hospital, Sheffield, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen B","family":"Wharton","sequence":"additional","affiliation":[{"name":"2 Department of Histopathology, Royal Hallamshire Hospital, Sheffield, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J","family":"Connolly","sequence":"additional","affiliation":[{"name":"3 Department of Neuroradiology, Royal Hallamshire Hospital, Sheffield, UK"},{"name":"4 Department of Neuroradiology, Sheffield Children's Hospital, Sheffield, S10 2TH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saurabh","family":"Sinha","sequence":"additional","affiliation":[{"name":"1 Department of Neurosurgery, Royal Hallamshire Hospital, Sheffield, UK"},{"name":"5 Department of Neurosurgery, Sheffield Children's Hospital, Sheffield, S10 2TH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J","family":"Dimitri","sequence":"additional","affiliation":[{"name":"6 Department of Paediatric Endocrinology, Sheffield Children's Hospital, Sheffield, S10 2TH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"ref411","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/j.jocn.2007.05.028","article-title":"Sellar xanthogranuloma manifesting as obstructive hydrocephalus","volume":"15","year":"2008","journal-title":"Journal of Clinical Neuroscience"},{"key":"ref401","doi-asserted-by":"crossref","first-page":"3935","DOI":"10.1210\/jc.2012-2069","article-title":"Xanthogranuloma, Rathke's cyst, and childhood craniopharyngioma: results of prospective multinational studies of children and adolescents with rare sellar malformations","volume":"97","year":"2012","journal-title":"Journal of Clinical 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