{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:17:23Z","timestamp":1784557043840,"version":"3.55.0"},"reference-count":14,"publisher":"Bioscientifica","content-domain":{"domain":["edm.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2014,12,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Tuberculosis (TB) is an important cause of mortality and morbidity across the world. In 2\u20135% of all cases of systemic TB, the C is affected, with lesions reported in the meninges, cortex and ventricles. Intrasellar tuberculomas, however, are extremely rare. We report the interesting case of a young female patient who presented with secondary hypothyroidism and hyperprolactinaemia. She was treated successfully for pituitary TB. We also highlight and discuss some interesting (and hitherto unreported) endocrine issues. Radiological and histological features and treatment of pituitary TB are discussed using this case as an example.<\/jats:p>\n                  <jats:sec>\n                    <jats:title>Learning points<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Intrasellar TB continues to be a rare presentation, but incidence and prevalence are expected to grow with increasing numbers of multidrug-resistant TB and shrinking geographical boundaries across the world.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Pituitary TB can present with features of a typical adenoma, but has certain radiological and histological features that help to differentiate from an adenoma.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Patients can present with a variety of endocrine abnormalities at different times.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>The presence of an intrasellar mass in individuals at a high risk of developing TB, or with a previous history of systemic TB, should prompt the diagnosis of pituitary TB. In such individuals, it may be worth considering a trial of anti-tuberculous therapy, before considering surgery.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1530\/edm-14-0091","type":"journal-article","created":{"date-parts":[[2015,1,19]],"date-time":"2015-01-19T06:39:23Z","timestamp":1421649563000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-2","source":"Crossref","is-referenced-by-count":1,"title":["Tuberculosis in the pituitary fossa: a common pathology in an uncommon site"],"prefix":"10.1530","volume":"2014","author":[{"given":"K","family":"Majumdar","sequence":"first","affiliation":[{"name":"University College London Hospitals NHS Foundation Trust, Diabetes and Endocrinology, 250 Euston Road, London NW1 2PG, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Barnard","sequence":"additional","affiliation":[{"name":"1 Whittington Hospital, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Ramachandra","sequence":"additional","affiliation":[{"name":"1 Whittington Hospital, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Berovic","sequence":"additional","affiliation":[{"name":"1 Whittington Hospital, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Powell","sequence":"additional","affiliation":[{"name":"2 National Hospital for Neurology and Neurosurgery, Neurosurgery, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"ref31","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1136\/bmj.1.3313.1127","article-title":"Tuberculoma of the pituitary body","volume":"1","year":"1924","journal-title":"BMJ"},{"key":"ref111","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/S0303-8467(00)00063-9","article-title":"Intrasellar tuberculomas \u2013 an enigmatic pituitary infection: a series of 18 cases","volume":"102","year":"2000","journal-title":"Clinical Neurology and Neurosurgery"},{"key":"ref21","first-page":"679","article-title":"Tuberculomas of the brain in Britain","volume":"48","year":"1972","journal-title":"Journal of Postgraduate Medicine"},{"key":"ref91","first-page":"679","article-title":"Tuberculomas of the brain in Britain","volume":"48","year":"1972","journal-title":"Journal of Postgraduate Medicine"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1212\/WNL.31.9.1133","article-title":"Intracranial tuberculoma: case report and review of the literature","volume":"31","year":"1981","journal-title":"Neurology"},{"key":"ref01","article-title":"Global Report","year":"2012","journal-title":"World Health Organization Tuberculosis"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1023\/A:1023352813641","article-title":"Pituitary tuberculoma: an unusual lesion of sellar region","volume":"5","year":"2002","journal-title":"Pituitary"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s11102-006-5420-2","article-title":"Suprasellar tubercular abscess presenting as panhypopituitarism: a common lesion in an uncommon site with a brief review of literature","volume":"9","year":"2006","journal-title":"Pituitary"},{"key":"ref101","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1136\/bmj.1.3313.1127","article-title":"Tuberculoma of the pituitary body","volume":"1","year":"1924","journal-title":"BMJ"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1212\/WNL.31.9.1133","article-title":"Intracranial tuberculoma: case report and review of the literature","volume":"31","year":"1981","journal-title":"Neurology"},{"key":"ref121","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1023\/A:1023352813641","article-title":"Pituitary tuberculoma: an unusual lesion of sellar region","volume":"5","year":"2002","journal-title":"Pituitary"},{"key":"ref131","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s11102-006-5420-2","article-title":"Suprasellar tubercular abscess presenting as panhypopituitarism: a common lesion in an uncommon site with a brief review of literature","volume":"9","year":"2006","journal-title":"Pituitary"},{"key":"ref71","article-title":"Global Report","year":"2012","journal-title":"World Health Organization Tuberculosis"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/S0303-8467(00)00063-9","article-title":"Intrasellar tuberculomas \u2013 an enigmatic pituitary infection: a series of 18 cases","volume":"102","year":"2000","journal-title":"Clinical Neurology and Neurosurgery"}],"container-title":["Endocrinology, Diabetes &amp; Metabolism Case Reports"],"original-title":[],"link":[{"URL":"https:\/\/edm.bioscientifica.com\/view\/journals\/edm\/2014\/1\/EDM14-0091.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/edm.bioscientifica.com\/downloadpdf\/journals\/edm\/2014\/1\/EDM14-0091.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:46:00Z","timestamp":1784555160000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.bioscientifica.com\/edm\/article\/3016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,1]]},"references-count":14,"URL":"https:\/\/doi.org\/10.1530\/edm-14-0091","relation":{},"ISSN":["2052-0573"],"issn-type":[{"value":"2052-0573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,1]]}}}