{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:17:29Z","timestamp":1784557049641,"version":"3.55.0"},"reference-count":26,"publisher":"Bioscientifica","content-domain":{"domain":["edm.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2015,6,1]]},"abstract":"Summary<\/jats:title>\n Cerebral vascular accidents are caused by vasospasm when induced by preeclampsia or by dopamine agonists. However, six arteries nourish the pituitary and prevent against vasospasm-induced damage, which up until now has not been thought to occur. Bromocriptine was used to arrest lactation in a 31-year-old with secondary amenorrhea following preeclampsia and fetal demise at 28 weeks gestation. Tests and history revealed panhypopituitarism not associated with hemorrhage or mass infarction but instead caused by vasospasm. The present study is the first report of pituitary damage from a non-hemorrhagic, vaso-occlusive event in the literature. In keeping with Sheehan's and Simon's syndromes, we have named pituitary damage resulting from vaso-occlusion as Dahan's syndrome, and a literature review suggests that it may be a common and previously overlooked disorder.<\/jats:p>\n \n Learning points<\/jats:title>\n \n \n \n Vasospasm can cause damage to the pituitary gland, although it was not previously believed to do so.<\/jats:p>\n <\/jats:list-item>\n \n Preeclampsia and the use of a dopamine agonist, particularly in the peripartum state, may trigger vasospasm.<\/jats:p>\n <\/jats:list-item>\n \n Vasospasm resulting from dopamine agonists may be a common cause of injury to the pituitary gland, and it may have been overlooked in the past.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1530\/edm-15-0001","type":"journal-article","created":{"date-parts":[[2015,6,2]],"date-time":"2015-06-02T05:24:06Z","timestamp":1433222646000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-2","source":"Crossref","is-referenced-by-count":1,"title":["Pituitary injury and persistent hypofunction resulting from a peripartum non-hemorrhagic, vaso-occlusive event"],"prefix":"10.1530","volume":"2015","author":[{"given":"Anita","family":"Kuriya","sequence":"first","affiliation":[{"name":"1 Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, McGill University Health Center, 687 Pine Avenue West F 6.58, Montreal, Quebec, Canada H3A 1A1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David V","family":"Morris","sequence":"additional","affiliation":[{"name":"2 Division of Endocrinology, McGill University Health Center, 687 Pine Avenue West F 6.58, Montreal, Quebec, Canada H3A 1A1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael H","family":"Dahan","sequence":"additional","affiliation":[{"name":"1 Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, McGill University Health Center, 687 Pine Avenue West F 6.58, Montreal, Quebec, Canada H3A 1A1"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"ref31","first-page":"409","article-title":"Delayed ischemic stroke associated with bromocriptine-induced reversible cerebral vasoconstriction syndrome","volume":"34","year":"2012","journal-title":"Neurological Sciences"},{"key":"ref201","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1080\/07435800902841306","article-title":"Empty sella may be the final outcome in lymphocytic hypophysitis","volume":"34","year":"2009","journal-title":"Endocrine Research"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1080\/07435800902841306","article-title":"Empty sella may be the final outcome in lymphocytic hypophysitis","volume":"34","year":"2009","journal-title":"Endocrine Research"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1161\/STROKEAHA.114.005129","article-title":"Acute cerebrovascular disease occurring after hospital discharge for labor and delivery","volume":"45","year":"2014","journal-title":"Stroke"},{"key":"ref151","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1161\/STROKEAHA.114.005129","article-title":"Acute cerebrovascular disease occurring after hospital discharge for labor and delivery","volume":"45","year":"2014","journal-title":"Stroke"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1472-6823-12-4","article-title":"Post-partum pituitary insufficiency and livedo reticularis presenting a diagnostic challenge in a resource limited setting in Tanzania: a case report, clinical discussion and brief review of existing literature","volume":"12","year":"2012","journal-title":"BMC Endocrine Disorders"},{"key":"ref101","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1046\/j.1365-2265.1999.00754.x","article-title":"Classical pituitary apoplexy: clinical features, management and outcome","volume":"51","year":"1999","journal-title":"Clinical Endocrinology"},{"key":"ref181","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.fertnstert.2011.05.012","article-title":"Hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome with pituitary apoplexy","volume":"96","year":"2011","journal-title":"Fertility and Sterility"},{"key":"ref191","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1472-6823-12-4","article-title":"Post-partum pituitary insufficiency and livedo reticularis presenting a diagnostic challenge in a resource limited setting in Tanzania: a case report, clinical discussion and brief review of existing literature","volume":"12","year":"2012","journal-title":"BMC Endocrine Disorders"},{"key":"ref231","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1046\/j.1365-2265.1999.00754.x","article-title":"Classical pituitary apoplexy: clinical features, management and outcome","volume":"51","year":"1999","journal-title":"Clinical Endocrinology"},{"key":"ref241","first-page":"270","article-title":"Primary empty sella (PES): a review of 175 cases","volume":"2","year":"2013","journal-title":"Pituitary"},{"key":"ref81","first-page":"72","article-title":"Pituitary autoimmune disease: nuances in clinical presentation","volume":"42","year":"2012","journal-title":"Endocrine"},{"key":"ref141","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0002-9378(00)70397-8","article-title":"Postpartum stroke: a twenty-year experience","volume":"183","year":"2000","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1007\/s13244-014-0362-0","article-title":"Pituitary apoplexy: an update on clinical and imaging features","volume":"5","year":"2014","journal-title":"Insights into Imaging"},{"key":"ref171","first-page":"822","article-title":"Puerperal hypertension, stroke, and seizures after suppression of lactation with bromocriptine","volume":"66","year":"1985","journal-title":"Obstetrics and Gynecology"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.fertnstert.2011.05.012","article-title":"Hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome with pituitary apoplexy","volume":"96","year":"2011","journal-title":"Fertility and Sterility"},{"key":"ref41","first-page":"822","article-title":"Puerperal hypertension, stroke, and seizures after suppression of lactation with bromocriptine","volume":"66","year":"1985","journal-title":"Obstetrics and Gynecology"},{"key":"ref221","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1007\/s13244-014-0362-0","article-title":"Pituitary apoplexy: an update on clinical and imaging features","volume":"5","year":"2014","journal-title":"Insights into Imaging"},{"key":"ref251","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.4158\/EP14120.OR","article-title":"Pituitary apoplexy in nonfunctioning pituitary macroadenomas: a case\u2013control study","volume":"20","year":"2014","journal-title":"Endocrine Practice"},{"key":"ref121","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.4158\/EP14120.OR","article-title":"Pituitary apoplexy in nonfunctioning pituitary macroadenomas: a case\u2013control study","volume":"20","year":"2014","journal-title":"Endocrine Practice"},{"key":"ref161","first-page":"409","article-title":"Delayed ischemic stroke associated with bromocriptine-induced reversible cerebral vasoconstriction syndrome","volume":"34","year":"2012","journal-title":"Neurological Sciences"},{"key":"ref131","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1056\/NEJMoa1311485","article-title":"Risk of thrombotic event after the 6-week postpartum period","volume":"370","year":"2014","journal-title":"New England Journal of Medicine"},{"key":"ref211","first-page":"72","article-title":"Pituitary autoimmune disease: nuances in clinical presentation","volume":"42","year":"2012","journal-title":"Endocrine"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0002-9378(00)70397-8","article-title":"Postpartum stroke: a twenty-year experience","volume":"183","year":"2000","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"ref01","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1056\/NEJMoa1311485","article-title":"Risk of thrombotic event after the 6-week postpartum period","volume":"370","year":"2014","journal-title":"New England Journal of Medicine"},{"key":"ref111","first-page":"270","article-title":"Primary empty sella (PES): a review of 175 cases","volume":"2","year":"2013","journal-title":"Pituitary"}],"container-title":["Endocrinology, Diabetes & Metabolism Case Reports"],"original-title":[],"link":[{"URL":"https:\/\/edm.bioscientifica.com\/view\/journals\/edm\/2015\/1\/EDM15-0001.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/edm.bioscientifica.com\/downloadpdf\/journals\/edm\/2015\/1\/EDM15-0001.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:46:02Z","timestamp":1784555162000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.bioscientifica.com\/edm\/article\/3217"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,1]]},"references-count":26,"URL":"https:\/\/doi.org\/10.1530\/edm-15-0001","relation":{},"ISSN":["2052-0573"],"issn-type":[{"value":"2052-0573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,1]]}}}