{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T19:17:32Z","timestamp":1789586252979,"version":"build-2803163510"},"reference-count":18,"publisher":"Bioscientifica","content-domain":{"domain":["edm.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2015,8,1]]},"abstract":"Summary<\/jats:title>\n A 55-year-old female patient presented to the endocrine clinic with Grave's disease. She was initially treated with carbimazole. After an early relapse, a decision was made to proceed with radioactive iodine therapy. Four days after radioiodine administration, she presented to the emergency department with chest tightness and dyspnea due to heart failure. Biochemistry revealed thyrotoxicosis and significantly elevated Troponin-T. There was ST segment elevation on electrocardiography. However, coronary angiography was normal. Ventricular function was fully restored after 6 weeks of supportive medical management. A diagnosis of stress cardiomyopathy following radioactive iodine therapy was made. This is the second case reported in the literature so far to the best of our knowledge.<\/jats:p>\n \n Learning points<\/jats:title>\n \n \n \n Stress cardiomyopathy in the context of radiation thyroiditis is a rare complication following radioiodine therapy.<\/jats:p>\n <\/jats:list-item>\n \n A degree of awareness is essential because the approach is multidisciplinary. Management is mainly supportive and cardiac dysfunction is completely reversible in most cases.<\/jats:p>\n <\/jats:list-item>\n \n The pathogenesis of this condition remains unclear. Post-menopausal women and susceptible individuals appear to be pre-disposed.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1530\/edm-15-0053","type":"journal-article","created":{"date-parts":[[2015,8,18]],"date-time":"2015-08-18T04:10:51Z","timestamp":1439871051000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-2","source":"Crossref","is-referenced-by-count":5,"title":["Stress cardiomyopathy (Takotsubo) following radioactive iodine therapy"],"prefix":"10.1530","volume":"2015","author":[{"given":"Anastasia","family":"Dimakopoulou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karunakaran","family":"Vithian","sequence":"additional","affiliation":[{"name":"2 Colchester Hospital University NHS Foundation Trust, Colchester, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Gannon","sequence":"additional","affiliation":[{"name":"2 Colchester Hospital University NHS Foundation Trust, Colchester, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan","family":"Harkness","sequence":"additional","affiliation":[{"name":"2 Colchester Hospital University NHS Foundation Trust, Colchester, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"ref41","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1056\/NEJM200102153440707","article-title":"Thyroid hormone and the cardiovascular system","volume":"344","year":"2001","journal-title":"New England Journal of Medicine"},{"key":"ref51","article-title":"- type cardiomyopathy due to multivessel spasm InClinical Aspect of Myocardial From Ischemia to Heart Failure Kagakuhyouronsha","author":"Sato","year":"1990","journal-title":"Injury"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1056\/NEJMct1007101","article-title":"Radioiodine therapy for hyperthyroidism","volume":"364","year":"2011","journal-title":"New England Journal of Medicine"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"126","DOI":"10.3810\/pgm.2009.05.2012","article-title":"An association between Takotsubo cardiomyopathy and thyroid storm","volume":"121","year":"2009","journal-title":"Postgraduate Medicine"},{"key":"ref131","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1056\/NEJM200102153440707","article-title":"Thyroid hormone and the cardiovascular system","volume":"344","year":"2001","journal-title":"New England Journal of Medicine"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.ijcard.2015.02.058","article-title":"Can thyroid break your heart? 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Role of thyroid in Takotsubo cardiomyopathy: a single center retrospective study","volume":"184","year":"2015","journal-title":"International Journal of Cardiology"},{"key":"ref91","first-page":"350","article-title":"Takotsubo cardiomyopathy following radioiodine therapy for toxic multinodular goitre","volume":"67","year":"2009","journal-title":"Netherlands Journal of Medicine"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1210\/jc.2012-3459","article-title":"Comparison of mortality in hyperthyroidism during periods of treatment with thionamides and after radioiodine","volume":"98","year":"2013","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref161","article-title":"College of Physicians Radioiodine in the management of benign thyroid disease : clinical guidelines Report of a Working Party","author":"London","year":"2007","journal-title":"Royal"},{"key":"ref171","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1210\/jc.2012-3459","article-title":"Comparison of mortality in hyperthyroidism during periods of treatment with thionamides and after radioiodine","volume":"98","year":"2013","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref111","doi-asserted-by":"crossref","first-page":"858","DOI":"10.7326\/0003-4819-141-11-200412070-00010","article-title":"Systematic review: transient left ventricular apical ballooning: a syndrome that mimics ST-segment elevation myocardial infarction","volume":"141","year":"2004","journal-title":"Annals of Internal Medicine"}],"container-title":["Endocrinology, Diabetes & Metabolism Case Reports"],"original-title":[],"link":[{"URL":"https:\/\/edm.bioscientifica.com\/view\/journals\/edm\/2015\/1\/EDM15-0053.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/edm.bioscientifica.com\/downloadpdf\/journals\/edm\/2015\/1\/EDM15-0053.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:46:08Z","timestamp":1784555168000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.bioscientifica.com\/edm\/article\/3051"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8,1]]},"references-count":18,"URL":"https:\/\/doi.org\/10.1530\/edm-15-0053","relation":{},"ISSN":["2052-0573"],"issn-type":[{"value":"2052-0573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,1]]}}}