{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:16:41Z","timestamp":1784557001724,"version":"3.55.0"},"reference-count":48,"publisher":"Bioscientifica","content-domain":{"domain":["edm.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2015,10,1]]},"abstract":"Summary<\/jats:title>\n Insulin autoimmune syndrome (IAS) is a rare cause of hyperinsulinemic hypoglycaemia, which is known to occur in association with the use of sulfhydryl-containing drugs and autoimmune disorders. We describe a patient with hitherto an unreported association of IAS with ankylosing spondylitis. We have also performed and described a simplified method of polyethylene glycol (PEG) precipitation of an insulin bound antibody in the serum.<\/jats:p>\n \n Learning points<\/jats:title>\n \n \n \n IAS should be considered in differential diagnosis of endogenous hyperinsulinemic hypoglycaemia.<\/jats:p>\n <\/jats:list-item>\n \n Ankylosing spondylitis can be associated with IAS apart from several other autoimmune diseases.<\/jats:p>\n <\/jats:list-item>\n \n Very high serum insulin levels (100\u201310\u200a000\u200a\u03bcU\/ml) are frequently seen in IAS.<\/jats:p>\n <\/jats:list-item>\n \n When faced with very high serum insulin before suspecting insulinoma, it is advisable that PEG precipitation of serum be done to identify antibody bound insulin.<\/jats:p>\n <\/jats:list-item>\n \n A clinical suspicion of IAS can avoid expensive imaging and unnecessary surgery in affected patients.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1530\/edm-15-0090","type":"journal-article","created":{"date-parts":[[2015,10,23]],"date-time":"2015-10-23T10:41:10Z","timestamp":1445596870000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-2","source":"Crossref","is-referenced-by-count":3,"title":["Rare association of insulin autoimmune syndrome with ankylosing spondylitis"],"prefix":"10.1530","volume":"2015","author":[{"given":"Nishant","family":"Raizada","sequence":"first","affiliation":[{"name":"1 Department of Endocrinology and Metabolism, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S H","family":"Rahaman","sequence":"additional","affiliation":[{"name":"1 Department of Endocrinology and Metabolism, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Kandasamy","sequence":"additional","affiliation":[{"name":"2 Department of Radiology, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V P","family":"Jyotsna","sequence":"additional","affiliation":[{"name":"1 Department of Endocrinology and Metabolism, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"ref431","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.4049\/jimmunol.111.4.1219","article-title":"Detection of antibodies and soluble antigen antibody complexes by precipitation with polyethylene glycol","volume":"111","year":"1973","journal-title":"Journal of Immunology"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.2337\/diab.44.10.1227","article-title":"Differential immunogenetic determinants of polyclonal insulin autoimmune syndrome (Hirata's disease) and monoclonal insulin autoimmune 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