{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:17:31Z","timestamp":1784557051051,"version":"3.55.0"},"reference-count":10,"publisher":"Bioscientifica","content-domain":{"domain":["edm.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,5,21]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Struma ovarii is a rare ovarian teratoma characterized by the presence of thyroid tissue as the major component. Malignant transformation of the thyroidal component (malignant struma ovarii) has been reported in approximately 5% of struma ovarii. The management and follow-up of this unusual disease remain controversial. We report the case of a woman with a history of autoimmune thyroiditis and a previous resection of a benign struma ovarii that underwent hystero-annexiectomy for malignant struma ovarii with multiple papillary thyroid cancer foci and peritoneal involvement. Total thyroidectomy and subsequent radioiodine treatment lead to complete disease remission after 104 months of follow-up. The diagnosis and natural progression of malignant struma ovarii are difficult to discern, and relapses can occur several years after diagnosis. A multidisciplinary approach is mandatory; after surgical excision of malignant struma, thyroidectomy in combination with\n                    <jats:sup>131<\/jats:sup>\n                    I therapy should be considered after risk stratification in accordance with a standard approach in differentiated thyroid cancer patients.\n                  <\/jats:p>\n                  <jats:sec>\n                    <jats:title>Learning points<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Malignant struma ovarii is a rare disease; diagnosis is difficult and management is not well defined.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Predominant sites of metastasis are adjacent pelvic structures.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>\n                            Thyroidectomy and\n                            <jats:sup>131<\/jats:sup>\n                            I therapy should be considered after risk stratification in accordance with standard approaches in DTC patients.\n                          <\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1530\/edm-16-0030","type":"journal-article","created":{"date-parts":[[2016,5,23]],"date-time":"2016-05-23T11:17:14Z","timestamp":1464002234000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-2","source":"Crossref","is-referenced-by-count":2,"title":["Metastatic malignant struma ovarii with coexistence of Hashimoto\u2019s thyroiditis"],"prefix":"10.1530","volume":"2016","author":[{"given":"Marco","family":"Russo","sequence":"first","affiliation":[{"name":"1Endocrinology, Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilenia","family":"Marturano","sequence":"additional","affiliation":[{"name":"2Endocrinology, Department of Clinical and Experimental Medicine, University of Catania, Garibaldi-Nesima Hospital, Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romilda","family":"Masucci","sequence":"additional","affiliation":[{"name":"3Surgical Oncology, Garibaldi-Nesima Hospital, Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melania","family":"Caruso","sequence":"additional","affiliation":[{"name":"4Gynecology and Obstetrics, Garibaldi-Nesima Hospital, Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Concetta","family":"Fornito","sequence":"additional","affiliation":[{"name":"5Nuclear Medicine, Garibaldi-Nesima Hospital, Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dario","family":"Tumino","sequence":"additional","affiliation":[{"name":"2Endocrinology, Department of Clinical and Experimental Medicine, University of Catania, Garibaldi-Nesima Hospital, Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Tavarelli","sequence":"additional","affiliation":[{"name":"2Endocrinology, Department of Clinical and Experimental Medicine, University of Catania, Garibaldi-Nesima Hospital, Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastiano","family":"Squatrito","sequence":"additional","affiliation":[{"name":"2Endocrinology, Department of Clinical and Experimental Medicine, University of Catania, Garibaldi-Nesima Hospital, Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Pellegriti","sequence":"additional","affiliation":[{"name":"6Endocrinology, Garibaldi-Nesima Hospital, Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"key20160526145438563_bib1","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1007\/978-1-4419-0489-8_16","article-title":"Germ cell tumors of the ovary.","volume-title":"Blaustein\u2019s Pathology of the Female Genital Tract","author":"Talerman","year":"2011","edition":"edn 3"},{"key":"key20160526145438563_bib2","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/j.ygyno.2004.06.003","article-title":"Struma Ovarii with a focus of papillary thyroid cancer: a case report and review of the literature","volume":"94","author":"Makani","year":"2004","journal-title":"Gynecologic Oncology"},{"key":"key20160526145438563_bib3","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1089\/thy.2014.0328","article-title":"Malignant struma ovarii: a population-level analysis of a large series of 68 patients","volume":"25","author":"Goffredo","year":"2015","journal-title":"Thyroid"},{"issue":"4","key":"key20160526145438563_bib4","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/ncpendmet0887","article-title":"Malignant struma ovarii","volume":"2008","author":"Yassa","year":"2008","journal-title":"Nature Clinical Practice Endocrinology & Metabolism"},{"key":"key20160526145438563_bib5","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1097\/00004347-199310000-00008","article-title":"Proliferative and histologically malignant struma ovarii: a clinicopathologic study of 54 cases","volume":"12","author":"Devaney","year":"1993","journal-title":"International Journal of Gynecologic Pathology"},{"key":"key20160526145438563_bib6","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1055\/s-2007-973853","article-title":"A special case of bilateral ovarian metastases in a woman with papillary carcinoma of the thyroid","volume":"115","author":"Brogioni","year":"2007","journal-title":"Experimental and Clinical Endocrinology & Diabetes"},{"key":"key20160526145438563_bib7","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/S0090-8258(03)00141-0","article-title":"Malignant struma ovarii: a case report and analysis of cases reported in the literature with focus on survival and I131 therapy","volume":"89","author":"DeSimone","year":"2007","journal-title":"Gynecologic Oncology"},{"issue":"5","key":"key20160526145438563_bib8","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1186\/1752-1947-5-572","article-title":"Struma ovarii presenting with Hashimoto\u2019s thyroiditis: a case report","volume":"2011","author":"Bozkurt","year":"2011","journal-title":"Journal of Medical Case Reports"},{"key":"key20160526145438563_bib9","doi-asserted-by":"crossref","first-page":"41","DOI":"10.3109\/09513599809024969","article-title":"Hashimoto\u2019s disease in a papillary carcinoma of the thyroid originating in a teratoma of the ovary (malignant struma ovarii)","volume":"12","author":"Doldi","year":"1998","journal-title":"Gynecological Endocrinology"},{"key":"key20160526145438563_bib10","doi-asserted-by":"crossref","first-page":"109","DOI":"10.14310\/horm.2002.1261","article-title":"Autoimmunity in differentiated thyroid cancer: Significance and related clinical problems","volume":"9","author":"Feldt-Rasmussen","year":"2010","journal-title":"Hormones"}],"container-title":["Endocrinology, Diabetes &amp; Metabolism Case Reports"],"original-title":[],"link":[{"URL":"https:\/\/edm.bioscientifica.com\/view\/journals\/edm\/2016\/1\/EDM16-0030.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/edm.bioscientifica.com\/downloadpdf\/journals\/edm\/2016\/1\/EDM16-0030.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:46:18Z","timestamp":1784555178000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.bioscientifica.com\/edm\/article\/3152"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,21]]},"references-count":10,"URL":"https:\/\/doi.org\/10.1530\/edm-16-0030","relation":{},"ISSN":["2052-0573"],"issn-type":[{"value":"2052-0573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,21]]}}}