{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:16:42Z","timestamp":1784557002616,"version":"3.55.0"},"reference-count":11,"publisher":"Bioscientifica","content-domain":{"domain":["edm.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,12,17]]},"abstract":"Summary<\/jats:title>\n Non-Hodgkin lymphoma (NHL) is a hematological tumor caused by abnormal lymphoid proliferation. NHL can arise in any part of the body, including central nervous system (CNS). However, pituitary involvement is a quite rare presentation. The diffuse large B-cell lymphoma (DLBCL) is the most common subtype when pituitary is infiltrated. Here, we report a case of pituitary infiltration of NHL DLBCL type in a woman with hypopituitarism and an infundibulum-hypophysitis-like image on magnetic resonance imaging (MRI). A female aged 64 years, complained of dyspepsia, fatigue, weight loss and urine volume increment with thirst. Endoscopy and gastric biopsy confirmed diffuse large B-cell lymphoma. Treatment with chemotherapy using R-CHOP was initiated. During her hospitalization, hypotension and polyuria were confirmed. Hormonal evaluation was compatible with central diabetes insipidus and hypopituitarism. Simple T1 sequence of MRI showed thickening of the infundibular stalk with homogeneous enhancement. After lumbar puncture analysis, CNS infiltration was confirmed showing positive atypical lymphocytes. Pituitary and infundibular stalk size normalized after R-CHOP chemotherapy treatment. In conclusion, pituitary infiltration of NHL with infundibular-hypophysitis-like image on MRI is a rare finding. Clinical picture included hypopituitarism and central diabetes insipidus. Diagnosis should be suspected after biochemical analysis and MRI results. Treatment consists of chemotherapy against NHL and hormonal replacement for pituitary dysfunction.<\/jats:p>\n \n Learning points:<\/jats:title>\n \n \n Pituitary infiltration by lymphoma can present with signs and symptoms of panhypopituitarism and diabetes insipidus.<\/jats:p>\n <\/jats:list-item>\n \n MRI findings can resemble an autoimmune hypophysitis.<\/jats:p>\n <\/jats:list-item>\n \n Patients can recover pituitary function as well as normalization of MRI after chemotherapy treatment.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:sec>","DOI":"10.1530\/edm-16-0103","type":"journal-article","created":{"date-parts":[[2016,12,17]],"date-time":"2016-12-17T04:34:33Z","timestamp":1481949273000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-2","source":"Crossref","is-referenced-by-count":4,"title":["Infundibulo-hypophysitis-like radiological image in a patient with pituitary infiltration of a diffuse large B-cell non-Hodgkin lymphoma"],"prefix":"10.1530","volume":"2016","author":[{"given":"A","family":"Le\u00f3n-Su\u00e1rez","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism, Neuroendocrinology Clinic, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Tlalpan, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Rold\u00e1n-Sarmiento","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Neuroendocrinology Clinic, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Tlalpan, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M A","family":"G\u00f3mez-S\u00e1mano","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Neuroendocrinology Clinic, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Tlalpan, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Nava-De la Vega","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Neuroendocrinology Clinic, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Tlalpan, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V M","family":"Enr\u00edquez-Estrada","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Neuroendocrinology Clinic, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Tlalpan, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F J","family":"G\u00f3mez-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Neuroendocrinology Clinic, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Tlalpan, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Cuevas-Ramos","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Neuroendocrinology Clinic, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Tlalpan, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"key20170106143544018_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12902-015-0007-4","article-title":"A rare case of anasarca caused by infiltration of the pituitary gland by diffuse large B-cell lymphoma","volume":"15","author":"Kumabe","year":"2015","journal-title":"BMC Endocrine Disorders"},{"key":"key20170106143544018_bib2","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1016\/j.jocn.2013.10.042","article-title":"Anterior panhypopituitarism in diffuse large B-cell stage IV lymphoma","volume":"21","author":"Valeros","year":"2014","journal-title":"Journal of Clinical Neuroscience"},{"key":"key20170106143544018_bib3","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.3892\/ol.2013.1266","article-title":"Clinical features of patients with non-Hodgkin\u2019s lymphoma metastasizing to the pituitary glands","volume":"5","author":"Yang","year":"2013","journal-title":"Oncology Letters"},{"key":"key20170106143544018_bib4","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1472-6823-13-45","article-title":"Pituitary and adrenal involvement in diffuse large B-cell lymphoma, with recovery of their function after chemotherapy","volume":"13","author":"Nakashima","year":"2013","journal-title":"BMC Endocrine Disorders"},{"key":"key20170106143544018_bib5","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.beem.2011.07.003","article-title":"Pituitary incidentaloma","volume":"26","author":"Orija","year":"2012","journal-title":"Best Practice and Research Clinical Endocrinology and Metabolism"},{"key":"key20170106143544018_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3171\/foc.2004.16.4.9","article-title":"Metastases to the pituitary gland","volume":"16","author":"Fasset","year":"2004","journal-title":"Neurosurgical Focus"},{"key":"key20170106143544018_bib7","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1186\/1477-7819-10-137","article-title":"Breast cancer metastatic to the pituitary gland: a case report","volume":"10","author":"Spinelli","year":"2012","journal-title":"World Journal of Surgical Oncology"},{"key":"key20170106143544018_bib8","doi-asserted-by":"crossref","first-page":"4567","DOI":"10.1210\/jcem.86.10.7909","article-title":"Primary lymphoma of the pituitary: an emerging clinical entity","volume":"86","author":"Giustina","year":"2001","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"key20170106143544018_bib9","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/S0140-6736(76)93090-7","article-title":"Pituitary function in patients receiving intermittent cytotoxic and corticosteroid therapy for malignant lymphoma","volume":"1","author":"Naysmith","year":"1976","journal-title":"Lancet"},{"key":"key20170106143544018_bib10","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1210\/er.2004-0011","article-title":"Autoimmune hypophysitis","volume":"26","author":"Caturegli","year":"2005","journal-title":"Endocrine Reviews"},{"key":"key20170106143544018_bib11","doi-asserted-by":"crossref","first-page":"3460","DOI":"10.1210\/jc.2015-2146","article-title":"Pituitary Working Group of the German Society of Endocrinology. Treatment of primary hypophysitis in Germany","volume":"100","author":"Honegger","year":"2015","journal-title":"Journal of Clinical Endocrinology and Metabolism"}],"container-title":["Endocrinology, Diabetes & Metabolism Case Reports"],"original-title":[],"link":[{"URL":"https:\/\/edm.bioscientifica.com\/view\/journals\/edm\/2016\/1\/EDM16-0103.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/edm.bioscientifica.com\/downloadpdf\/journals\/edm\/2016\/1\/EDM16-0103.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:46:25Z","timestamp":1784555185000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.bioscientifica.com\/edm\/article\/3501"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,17]]},"references-count":11,"URL":"https:\/\/doi.org\/10.1530\/edm-16-0103","relation":{},"ISSN":["2052-0573"],"issn-type":[{"value":"2052-0573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,17]]}}}