{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:17:34Z","timestamp":1784557054676,"version":"3.55.0"},"reference-count":16,"publisher":"Bioscientifica","content-domain":{"domain":["edm.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,3,31]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Corticotroph adenomas are extremely rare in children and adolescents. We present a 15-year-old boy who was investigated for delayed puberty (A1P2G1, bilateral testicular volumes of 3\u2009mL each). There was no clinical or laboratory evidence suggestive of chronic illness, and the initial clinical impression was constitutional delay in puberty. Subsequently, MRI scan of the brain revealed the presence of a mixed cystic and solid pituitary lesion slightly displacing the optic chiasma. The lesion was removed by transphenoidal surgery and the biopsy confirmed the lesion to be pituitary adenoma. Furthermore, the adenoma cells also had Crooke\u2019s hyaline changes and were intensely positive for ACTH. However there was no clinical\/biochemical evidence of ACTH excess. There was a spontaneous pubertal progression twelve months after the surgery (A2P4G4, with bilateral testicular volume of 8\u2009mL). Crooke\u2019s cell adenoma is an extremely rare and aggressive variant of corticotroph adenoma that can uncommonly present as a silent corticotroph adenoma in adults. We report for the first time Crooke\u2019s cell adenoma in an adolescent boy presenting with delayed puberty.<\/jats:p>\n                  <jats:sec>\n                    <jats:title>Learning points:<\/jats:title>\n                    <jats:list list-type=\"bullet\">\n                      <jats:list-item>\n                        <jats:p>Constitutional delay of growth and puberty (CDGP) is a diagnosis of exclusion; hence a systematic and careful review should be undertaken while assessing boys with delayed puberty.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>Crooke\u2019s cell adenomas are a group of corticotroph adenomas that can rarely present in childhood and adolescence with delayed puberty.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>Crooke\u2019s cell adenomas can be clinically silent but are potentially aggressive tumours that require careful monitoring.<\/jats:p>\n                      <\/jats:list-item>\n                    <\/jats:list>\n                  <\/jats:sec>","DOI":"10.1530\/edm-16-0153","type":"journal-article","created":{"date-parts":[[2017,3,31]],"date-time":"2017-03-31T03:06:50Z","timestamp":1490929610000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-2","source":"Crossref","is-referenced-by-count":4,"title":["Silent Crooke\u2019s cell corticotroph adenoma of the pituitary gland presenting as delayed puberty"],"prefix":"10.1530","volume":"2017","author":[{"given":"Dinesh","family":"Giri","sequence":"first","affiliation":[{"name":"1Department of Paediatric Endocrinology, Alder Hey Children\u2019s NHS Foundation Trust, Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Roncaroli","sequence":"additional","affiliation":[{"name":"2Department of Histopathology, Alder Hey Children\u2019s Hospital, Liverpool UK"},{"name":"3Division of Neuroscience, University of Manchester, Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay","family":"Sinha","sequence":"additional","affiliation":[{"name":"4Department of Paediatric NeurosurgeryAlder Hey Children\u2019s Hospital, Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Didi","sequence":"additional","affiliation":[{"name":"1Department of Paediatric Endocrinology, Alder Hey Children\u2019s NHS Foundation Trust, Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Senthil","family":"Senniappan","sequence":"additional","affiliation":[{"name":"1Department of Paediatric Endocrinology, Alder Hey Children\u2019s NHS Foundation Trust, Liverpool 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