{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:16:50Z","timestamp":1784557010342,"version":"3.55.0"},"reference-count":44,"publisher":"Bioscientifica","content-domain":{"domain":["edm.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,4,21]]},"abstract":"Summary<\/jats:title>\n The craniopharyngiomas are solid cystic suprasellar tumors that can present extension to adjacent structures, conditioning pituitary and hypothalamic dysfunction. Within hypothalamic neuroendocrine dysfunction, we can find obesity, behavioral changes, disturbed circadian rhythm and sleep irregularities, imbalances in the regulation of body temperature, thirst, heart rate and\/or blood pressure and alterations in dietary intake (like anorexia). We present a rare case of anorexia\u2013cachexia syndrome like a manifestation of neuroendocrine dysfunction in a patient with a papillary craniopharyngioma. Anorexia\u2013cachexia syndrome is a complex metabolic process associated with underlying illness and characterized by loss of muscle with or without loss of fat mass and can occur in a number of diseases like cancer neoplasm, non-cancer neoplasm, chronic disease or immunodeficiency states like HIV\/AIDS. The role of cytokines and anorexigenic and orexigenic peptides are important in the etiology. The anorexia\u2013cachexia syndrome is a clinical entity rarely described in the literature and it leads to important function limitation, comorbidities and worsening prognosis.<\/jats:p>\n \n Learning points:<\/jats:title>\n \n \n Suprasellar lesions can result in pituitary and hypothalamic dysfunction.<\/jats:p>\n <\/jats:list-item>\n \n The hypothalamic neuroendocrine dysfunction is commonly related with obesity, behavioral changes, disturbed circadian rhythm and sleep irregularities, but rarely with anorexia\u2013cachexia.<\/jats:p>\n <\/jats:list-item>\n \n Anorexia\u2013cachexia syndrome is a metabolic process associated with loss of muscle, with or without loss of fat mass, in a patient with neoplasm, chronic disease or immunodeficiency states.<\/jats:p>\n <\/jats:list-item>\n \n Anorexia\u2013cachexia syndrome results in important function limitation, comorbidities that influence negatively on treatment, progressive clinical deterioration and bad prognosis that can lead the patient to death.<\/jats:p>\n <\/jats:list-item>\n \n Anorexia\u2013cachexia syndrome should be suspected in patients with emaciation and hypothalamic lesions.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:sec>","DOI":"10.1530\/edm-17-0018","type":"journal-article","created":{"date-parts":[[2017,4,21]],"date-time":"2017-04-21T03:38:14Z","timestamp":1492745894000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-2","source":"Crossref","is-referenced-by-count":5,"title":["Anorexia\u2013cachexia syndrome-like hypothalamic neuroendocrine dysfunction in a patient with a papillary craniopharyngioma"],"prefix":"10.1530","volume":"2017","author":[{"given":"Lourdes","family":"Balc\u00e1zar-Hern\u00e1ndez","sequence":"first","affiliation":[{"name":"1Endocrinology Department"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guadalupe","family":"Vargas-Ortega","sequence":"additional","affiliation":[{"name":"1Endocrinology Department"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yelitza","family":"Valverde-Garc\u00eda","sequence":"additional","affiliation":[{"name":"2Anatomic Pathology Department, Hospital de Especialidades, Centro M\u00e9dico Nacional Siglo XXI, Colonia Doctores, Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Mendoza-Zubieta","sequence":"additional","affiliation":[{"name":"1Endocrinology Department"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baldomero","family":"Gonz\u00e1lez-Virla","sequence":"additional","affiliation":[{"name":"1Endocrinology Department"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"key20170428124627359_bib1","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1016\/j.otc.2011.06.015","article-title":"Craniopharyngioma","volume":"44","author":"Stamm","year":"2011","journal-title":"Otolaryngologic Clinics of North America"},{"key":"key20170428124627359_bib2","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/B978-0-444-59602-4.00016-2","article-title":"Craniopharyngioma","volume":"124","author":"M\u00fcller","year":"2014","journal-title":"Handbook of Clinical Neurology"},{"key":"key20170428124627359_bib3","doi-asserted-by":"publisher","first-page":"237","DOI":"10.3171\/jns.1999.90.2.0237","article-title":"Surgical treatment of craniopharyngiomas: experience with 168 patients","volume":"90","author":"Fahlbusch","year":"1999","journal-title":"Journal of Neurosurgery"},{"key":"key20170428124627359_bib4","doi-asserted-by":"publisher","first-page":"547","DOI":"10.3171\/jns.1998.89.4.0547","article-title":"The descriptive epidemiology of craniopharyngioma","volume":"89","author":"Bunin","year":"1998","journal-title":"Journal of Neurosurgery"},{"key":"key20170428124627359_bib5","first-page":"203","article-title":"Nonglial tumours","author":"Parisi","year":"1993","journal-title":"Principles and Practice of Neuropathology"},{"key":"key20170428124627359_bib6","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1227\/00006123-199412000-00001","article-title":"Craniopharyngiomas: a clinicopathological analysis of factors predictive of recurrence and functional outcome","volume":"35","author":"Weiner","year":"1994","journal-title":"Neurosurgery"},{"key":"key20170428124627359_bib7","first-page":"778e784","article-title":"Craniopharyngioma in children: Marseille experience","volume":"21","author":"Lena","year":"2005","journal-title":"Child\u2019s Nervous System"},{"key":"key20170428124627359_bib8","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.clineuro.2007.10.013","article-title":"Craniopharyngioma: surgical experience of 309 cases in China","volume":"110","author":"Shi","year":"2008","journal-title":"Clinical Neurology and Neurosurgery"},{"key":"key20170428124627359_bib9","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1016\/j.arcmed.2012.10.005","article-title":"Reply: classification systems of adult craniopharyngiomas: the need for an accurate definition of the hypothalamus-tumor relationships","volume":"43","author":"Lopez-Serna","year":"2012","journal-title":"Archives of Medical Research"},{"key":"key20170428124627359_bib10","doi-asserted-by":"publisher","first-page":"389","DOI":"10.3390\/jcm4030389","article-title":"Neuroendocrine disorders in pediatric craniopharyngioma patients","volume":"4","author":"Daubenb\u00fcchel","year":"2015","journal-title":"Journal of clinical medicine"},{"key":"key20170428124627359_bib11","doi-asserted-by":"publisher","first-page":"403","DOI":"10.3171\/2010.8.PEDS09385","article-title":"Surgical management of giant pediatric craniopharyngiomas","volume":"6","author":"Elliott","year":"2010","journal-title":"Journal of Neurosurgery-Pediatrics"},{"key":"key20170428124627359_bib12","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1111\/j.1469-8749.2004.tb00476.x","article-title":"Outcome of craniopharyngioma in children: long-term complications and quality of life","volume":"46","author":"Poretti","year":"2004","journal-title":"Developmental Medicine and Child Neurology"},{"key":"key20170428124627359_bib13","first-page":"274","article-title":"A diencephalic syndrome of emaciation in infancy and childhood","volume":"26","author":"Russell","year":"1951","journal-title":"Archives of Disease in Childhood"},{"key":"key20170428124627359_bib14","doi-asserted-by":"publisher","first-page":"3972","DOI":"10.1210\/jc.2014-1680","article-title":"Diencephalic syndrome in childhood craniopharyngioma-results of German multicenter studies on 485 long-term survivors of childhood craniopharyngioma","volume":"99","author":"Hoffmann","year":"2014","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"key20170428124627359_bib15","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/S1072-7515(03)00382-X","article-title":"Understanding and managing cancer cachexia","volume":"197","author":"MacDonald","year":"2003","journal-title":"Journal of the American College of Surgeons"},{"key":"key20170428124627359_bib16","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1016\/j.jpainsymman.2008.06.005","article-title":"Anorexia-cachexia syndrome: a systematic review of the role of dietary polyunsaturated Fatty acids in the management of symptoms, survival, and quality of life","volume":"37","author":"Mazzotta","year":"2009","journal-title":"Journal of Pain and Symptom Management"},{"key":"key20170428124627359_bib17","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1016\/j.clnu.2008.06.013","article-title":"Cachexia: a new definition","volume":"27","author":"Evans","year":"2008","journal-title":"Clinical Nutrition"},{"key":"key20170428124627359_bib18","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/S1072-7515(03)00382-X","article-title":"Understanding and managing cancer cachexia","volume":"197","author":"MacDonald","year":"2003","journal-title":"Journal of the American College of Surgeons"},{"key":"key20170428124627359_bib19","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1016\/j.jpainsymman.2008.06.005","article-title":"Anorexia-cachexia syndrome: a systematic review of the role of dietary polyunsaturated Fatty acids in the management of symptoms, survival, and quality of life","volume":"37","author":"Mazzotta","year":"2009","journal-title":"Journal of pain and symptom management"},{"key":"key20170428124627359_bib20","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/0031-9384(96)00148-5","article-title":"Anorexia induced by chronic central administration of cytokines at estimated pathophysiological concentrations","volume":"60","author":"Plata-Salaman","year":"1996","journal-title":"Physiology and Behavior"},{"key":"key20170428124627359_bib21","doi-asserted-by":"crossref","first-page":"4032","DOI":"10.1210\/endo.141.11.7778","article-title":"Leukemia inhibitory factor mediates the hypothalamic pituitary adrenal axis response to inflammation","volume":"141","author":"Chesnokova","year":"2000","journal-title":"Endocrinology"},{"key":"key20170428124627359_bib22","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1056\/NEJM198403013100915","article-title":"Demonstration of circulating leukocytic pyrogen\/interleukin-1 during fever","volume":"310","author":"Bendtzen","year":"1984","journal-title":"New England Journal of Medicine"},{"key":"key20170428124627359_bib23","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1111\/j.1749-6632.1998.tb08323.x","article-title":"A physiologic role for IL-1 beta and TNF-alpha","volume":"856","author":"Krueger","year":"1998","journal-title":"Annals of New York Academy of Sciences"},{"key":"key20170428124627359_bib24","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1016\/j.bbi.2007.01.010","article-title":"Depressive disorders and immunity: 20 years of progress and discovery","volume":"21","author":"Irwin","year":"2007","journal-title":"Brain, Behavior, and Immunity"},{"key":"key20170428124627359_bib25","first-page":"R1394","article-title":"Anorexia induced by cytokine interactions at pathophysiological concentrations","volume":"270","author":"Sonti","year":"1996","journal-title":"American Physiological Society"},{"key":"key20170428124627359_bib26","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1097\/00001756-199602290-00038","article-title":"Anorexia induced by activators of the signal transducer gp130","volume":"7","author":"Plata-Salaman","year":"1996","journal-title":"Neuroreport"},{"key":"key20170428124627359_bib27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1006\/bbrc.2001.5849","article-title":"Molecular regulation of muscle cachexia: it may be more than the proteasome","volume":"290","author":"Hasselgren","year":"2002","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"key20170428124627359_bib28","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1016\/j.physbeh.2010.03.011","article-title":"Hypothalamic mechanisms in cachexia","volume":"100","author":"Grossberg","year":"2010","journal-title":"Physiology and Behavior"},{"key":"key20170428124627359_bib29","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1016\/S0899-9007(01)00507-X","article-title":"Anorectic effects of circulating cytokines: role of the vascular blood-brain barrier","volume":"17","author":"Banks","year":"2001","journal-title":"Nutrition"},{"issue":"Supplement 1","key":"key20170428124627359_bib30","first-page":"64","article-title":"Cytokines and anorexia: a brief overview","volume":"25","author":"Plata-Salaman","year":"1998","journal-title":"Seminars in Oncology"},{"key":"key20170428124627359_bib31","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/S0361-9230(99)00203-8","article-title":"Cytokine\u2013cytokine interactions and the brain","volume":"51","author":"Turrin","year":"2000","journal-title":"Brain Research Bulletin"},{"key":"key20170428124627359_bib32","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1210\/en.2009-1135","article-title":"Arcuate nucleus proopiomelanocortin neurons mediate the acute anorectic actions of leukemia inhibitory factor via gp130","volume":"151","author":"Grossberg","year":"2010","journal-title":"Endocrinology"},{"key":"key20170428124627359_bib33","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/j.tem.2009.02.002","article-title":"Role of central melanocortin pathways in energy homeostasis","volume":"20","author":"Garfield","year":"2009","journal-title":"Trends in Endocrinology and Metabolism"},{"key":"key20170428124627359_bib34","doi-asserted-by":"publisher","first-page":"1659","DOI":"10.1172\/JCI22521","article-title":"Role of leptin and melanocortin signaling in uremia-associated cachexia","volume":"115","author":"Cheung","year":"2005","journal-title":"Journal of Clinical Investigation"},{"key":"key20170428124627359_bib35","doi-asserted-by":"publisher","first-page":"1513","DOI":"10.1210\/en.2002-221099","article-title":"Differential role of melanocortin receptor subtypes in cachexia","volume":"144","author":"Marks","year":"2003","journal-title":"Endocrinology"},{"key":"key20170428124627359_bib36","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1038\/nature02440","article-title":"AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus","volume":"428","author":"Minokoshi","year":"2004","journal-title":"Nature"},{"key":"key20170428124627359_bib37","doi-asserted-by":"publisher","first-page":"3475","DOI":"10.1172\/JCI31743","article-title":"The central melanocortin system directly controls peripheral lipid metabolism","volume":"117","author":"Nogueiras","year":"2007","journal-title":"Journal of clinical investigation"},{"key":"key20170428124627359_bib38","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.cmet.2006.06.010","article-title":"Enhanced leptin sensitivity and improved glucose homeostasis in mice lacking suppressor of cytokine signaling-3 in POMC-expressing cells","volume":"4","author":"Kievit","year":"2006","journal-title":"Cell Metabolism"},{"key":"key20170428124627359_bib39","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1007\/s11011-008-9114-5","article-title":"Neuropsychiatric disorders related to interferon and interleukins treatment","volume":"24","author":"Myint","year":"2009","journal-title":"Metabolic Brain Disease"},{"key":"key20170428124627359_bib40","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1007\/978-0-585-37970-8_12","article-title":"Anhedonic and anxiogenic effects of cytokine exposure","volume":"461","author":"Anisman","year":"1999","journal-title":"Advances in Experimental Medicine and Biology"},{"key":"key20170428124627359_bib41","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/0006-8993(95)01415-2","article-title":"Endotoxin produces a depressive-like episode in rats","volume":"711","author":"Yirmiya","year":"1996","journal-title":"Brain Research"},{"key":"key20170428124627359_bib42","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/j.cmet.2008.01.007","article-title":"Activation of Stat3 signaling in AgRP neurons promotes locomotor activity","volume":"7","author":"Mesaros","year":"2008","journal-title":"Cell Metabolism"},{"key":"key20170428124627359_bib43","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1016\/j.cmet.2009.05.003","article-title":"Leptin-dependent control of glucose balance and locomotor activity by POMC neurons","volume":"9","author":"Huo","year":"2009","journal-title":"Cell Metabolism"},{"key":"key20170428124627359_bib44","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1038\/nn1455","article-title":"Anatomy and regulation of the central melanocortin system","volume":"8","author":"Cone","year":"2005","journal-title":"Nature Neuroscience"}],"container-title":["Endocrinology, Diabetes & Metabolism Case Reports"],"original-title":[],"link":[{"URL":"https:\/\/edm.bioscientifica.com\/view\/journals\/edm\/2017\/1\/EDM17-0018.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/edm.bioscientifica.com\/downloadpdf\/journals\/edm\/2017\/1\/EDM17-0018.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:46:32Z","timestamp":1784555192000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.bioscientifica.com\/edm\/article\/3462"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,21]]},"references-count":44,"URL":"https:\/\/doi.org\/10.1530\/edm-17-0018","relation":{},"ISSN":["2052-0573"],"issn-type":[{"value":"2052-0573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,21]]}}}