{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:16:43Z","timestamp":1784557003031,"version":"3.55.0"},"reference-count":10,"publisher":"Bioscientifica","content-domain":{"domain":["edm.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,9,4]]},"abstract":"Markedly elevated androgen levels can lead to clinical virilization in females. Clinical features of virilization in a female patient, in association with biochemical hyperandrogenism, should prompt a search for an androgen-producing tumor, especially of ovarian or adrenal origin. We herein report the case of a 60-year-old woman of Pakistani origin who presented with the incidental finding of male pattern baldness and hirsutism. Her serum testosterone level was markedly elevated at 21\u2009nmol\/L (normal range: 0.4\u20131.7\u2009nmol\/L), while her DHEAS level was normal, indicating a likely ovarian source of her elevated testosterone. Subsequently, a CT abdomen-pelvis was performed, which revealed a bulky right ovary, confirmed on MRI of the pelvis as an enlarged right ovary, measuring 2.9\u2009\u00d7\u20092.2\u2009cm transaxially. A laparoscopic bilateral salpingo-oophorectomy was performed, and histopathological examination and immunohistochemistry confirmed the diagnosis of a Leydig cell tumor, a rare tumor accounting for 0.1% of ovarian tumors. Surgical resection led to normalization of testosterone levels.<\/jats:p>\n \n Learning points:<\/jats:title>\n \n \n Hirsutism in postmenopausal women should trigger suspicion of androgen-secreting tumor<\/jats:p>\n <\/jats:list-item>\n \n Extremely elevated testosterone level plus normal DHEAS level point toward ovarian source<\/jats:p>\n <\/jats:list-item>\n \n Leydig cell tumor is extremely rare cause of hyperandrogenicity<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:sec>","DOI":"10.1530\/edm-17-0075","type":"journal-article","created":{"date-parts":[[2017,9,3]],"date-time":"2017-09-03T05:36:10Z","timestamp":1504416970000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-2","source":"Crossref","is-referenced-by-count":2,"title":["Marked hyperandrogenicity in a 60-year-old woman"],"prefix":"10.1530","volume":"2017","author":[{"given":"Khaled","family":"Aljenaee","sequence":"first","affiliation":[{"name":"1Department of Endocrinology, Royal College of Surgeons in Ireland, Connolly Hospital Blanchardstown, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sulaiman","family":"Ali","sequence":"additional","affiliation":[{"name":"2Departments of Endocrinology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong Keat","family":"Cheah","sequence":"additional","affiliation":[{"name":"1Department of Endocrinology, Royal College of Surgeons in Ireland, Connolly Hospital Blanchardstown, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Owen","family":"MacEneaney","sequence":"additional","affiliation":[{"name":"3Histopathology, Mater Misericordiae University Hospital, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niall","family":"Mulligan","sequence":"additional","affiliation":[{"name":"3Histopathology, Mater Misericordiae University Hospital, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Hickey","sequence":"additional","affiliation":[{"name":"4Department of Radiology, Connolly Hospital Blanchardstown, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tommy Kyaw","family":"Tun","sequence":"additional","affiliation":[{"name":"1Department of Endocrinology, Royal College of Surgeons in Ireland, Connolly Hospital Blanchardstown, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seamus","family":"Sreenan","sequence":"additional","affiliation":[{"name":"1Department of Endocrinology, Royal College of Surgeons in Ireland, Connolly Hospital Blanchardstown, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John H","family":"McDermott","sequence":"additional","affiliation":[{"name":"1Department of Endocrinology, Royal College of Surgeons in Ireland, Connolly Hospital Blanchardstown, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"key20170905151246766_bib1","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1097\/00000478-198711000-00002","article-title":"Ovarian steroid cell tumors (not otherwise specified). 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