{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:17:33Z","timestamp":1784557053673,"version":"3.55.0"},"reference-count":10,"publisher":"Bioscientifica","content-domain":{"domain":["edm.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,10,13]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    We report a patient with Graves\u2019 disease who remained persistently hyperthyroid after a total thyroidectomy and also developed\n                    <jats:italic>de novo<\/jats:italic>\n                    Graves\u2019 ophthalmopathy 5 months after surgery. She was subsequently found to have a mature cystic teratoma containing struma ovarii after undergoing a total hysterectomy and salpingo-oophorectomy for an incidental ovarian lesion.\n                  <\/jats:p>\n                  <jats:sec>\n                    <jats:title>Learning points:<\/jats:title>\n                    <jats:list list-type=\"bullet\">\n                      <jats:list-item>\n                        <jats:p>It is important to investigate for other causes of primary hyperthyroidism when thyrotoxicosis persists after total thyroidectomy.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>\n                          TSH receptor antibody may persist after total thyroidectomy and may potentially contribute to the development of\n                          <jats:italic>de novo<\/jats:italic>\n                          Graves\u2019 ophthalmopathy.\n                        <\/jats:p>\n                      <\/jats:list-item>\n                    <\/jats:list>\n                  <\/jats:sec>","DOI":"10.1530\/edm-17-0109","type":"journal-article","created":{"date-parts":[[2017,10,13]],"date-time":"2017-10-13T03:21:38Z","timestamp":1507864898000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-2","source":"Crossref","is-referenced-by-count":1,"title":["Persistent hyperthyroidism and de novo Graves\u2019 ophthalmopathy after total thyroidectomy"],"prefix":"10.1530","volume":"2017","author":[{"given":"Wei Lin","family":"Tay","sequence":"first","affiliation":[{"name":"1Department of Endocrinology, Singapore General Hospital, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wann Jia","family":"Loh","sequence":"additional","affiliation":[{"name":"2Department of Endocrinology, Changi General Hospital, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianne Ai Ling","family":"Lee","sequence":"additional","affiliation":[{"name":"3Department of Pathology, Sengkang Health, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiaw Ling","family":"Chng","sequence":"additional","affiliation":[{"name":"1Department of Endocrinology, Singapore General Hospital, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"key20171030103456556_bib1","doi-asserted-by":"crossref","first-page":"135","DOI":"10.3802\/jgo.2008.19.2.135","article-title":"Clinical characteristics of struma ovarii","volume":"19","author":"Yoo","year":"2008","journal-title":"Journal of Gynecologic Oncology"},{"key":"key20171030103456556_bib2","doi-asserted-by":"crossref","first-page":"883","DOI":"10.7326\/0003-4819-72-6-883","article-title":"Struma ovarii \u2013 ascitic, hyperthyroid, and asymptomatic syndromes","volume":"72","author":"Kempers","year":"1970","journal-title":"Annals of Internal 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