{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:17:33Z","timestamp":1784557053644,"version":"3.55.0"},"reference-count":0,"publisher":"Bioscientifica","content-domain":{"domain":["edm.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,11,9]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Herein, we present a 14-year-old patient with short stature (134\u2009cm) referred from Paediatrics to our department for complementary evaluation since growth hormone (GH) treatment failed to show any improvement. He was born premature and small for gestational age. Genital examination classified the patient as Tanner I\u2013II with small penis and testicular size for his age. Biochemical analyses revealed normal GH levels with low serum insulin-like growth factor-1 (IGF-1). Molecular diagnosis confirmed several mutations in\n                    <jats:italic>IGF1R<\/jats:italic>\n                    and\n                    <jats:italic>IGFALS<\/jats:italic>\n                    , and so he was diagnosed with Laron Syndrome or GH insensibility and treated with IGF-1 substitutive therapy.\n                  <\/jats:p>\n                  <jats:sec>\n                    <jats:title>Learning points:<\/jats:title>\n                    <jats:list list-type=\"bullet\">\n                      <jats:list-item>\n                        <jats:p>Evaluation of the GH\/IGF-1 axis when short stature does not respond to conservative treatment must be included in the ordinary practice.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>Laron Syndrome real incidence should be calculated once undiagnosed cases arise, as treatment, due to lack of market, is unaffordable.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>Even when adulthood is reached, and no longitudinal growth can be achieved, still IGF-1 treatment in Laron Syndrome patients should be pursued as metabolic and protective derangements could arise.<\/jats:p>\n                      <\/jats:list-item>\n                    <\/jats:list>\n                  <\/jats:sec>","DOI":"10.1530\/edm-17-0126","type":"journal-article","created":{"date-parts":[[2017,11,9]],"date-time":"2017-11-09T02:15:40Z","timestamp":1510193740000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-2","source":"Crossref","is-referenced-by-count":4,"title":["Growth hormone insensitivity: Mexican case report"],"prefix":"10.1530","volume":"2017","author":[{"given":"I","family":"Castilla-Cortazar","sequence":"first","affiliation":[{"name":"1Escuela de Medicina, Tecnologico de Monterrey, Monterrey, M\u00e9xico"},{"name":"2Fundaci\u00f3n de Investigaci\u00f3n HM Hospitales, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J R","family":"De Ita","sequence":"additional","affiliation":[{"name":"1Escuela de Medicina, Tecnologico de Monterrey, Monterrey, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G A","family":"Aguirre","sequence":"additional","affiliation":[{"name":"1Escuela de Medicina, Tecnologico de Monterrey, Monterrey, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Garc\u00eda\u2013Magari\u00f1o","sequence":"additional","affiliation":[{"name":"1Escuela de Medicina, Tecnologico de Monterrey, Monterrey, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Mart\u00edn-Estal","sequence":"additional","affiliation":[{"name":"1Escuela de Medicina, Tecnologico de Monterrey, Monterrey, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V J","family":"Lara-Diaz","sequence":"additional","affiliation":[{"name":"1Escuela de Medicina, Tecnologico de Monterrey, Monterrey, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M I","family":"Elizondo","sequence":"additional","affiliation":[{"name":"1Escuela de Medicina, Tecnologico de Monterrey, Monterrey, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","container-title":["Endocrinology, Diabetes &amp; Metabolism Case Reports"],"original-title":[],"link":[{"URL":"https:\/\/edm.bioscientifica.com\/view\/journals\/edm\/2017\/1\/EDM17-0126.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/edm.bioscientifica.com\/downloadpdf\/journals\/edm\/2017\/1\/EDM17-0126.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:46:43Z","timestamp":1784555203000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.bioscientifica.com\/edm\/article\/3658"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,9]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1530\/edm-17-0126","relation":{},"ISSN":["2052-0573"],"issn-type":[{"value":"2052-0573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,9]]}}}