{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T17:22:33Z","timestamp":1783444953929,"version":"3.54.6"},"reference-count":7,"publisher":"Bioscientifica","license":[{"start":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T00:00:00Z","timestamp":1771200000000},"content-version":"vor","delay-in-days":2968,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/deed.en_GB"}],"content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,1,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Pheochromocytoma is a rare tumor of the adrenal gland. It often presents with the classic triad of headache, palpitations and generalized sweating. Although not described as a typical symptom of pheochromocytoma, anxiety is the fourth most common symptom reported by patients suffering of pheochromocytoma. We report the case of a 64 year old man who had severe anxiety and panic disorder as presenting symptoms of pheochromocytoma. After 13 years of psychiatric follow-up, the patient was diagnosed with malignant pheochromocytoma. After surgical resection of his pheochromocytoma and his hepatic metastases, the major panic attacks completely disappeared, the anxiety symptoms improved significantly and the psychiatric medications were stopped except for a very low maintenance dose of venlafaxine. We found in our cohort of 160 patients with pheochromocytoma 2 others cases of apparently benign tumors with severe anxiety that resolved after pheochromocytoma resection. These cases highlight that pheochromocytoma should be included in the differential diagnosis of refractory anxiety disorder.<\/jats:p>\n                  <jats:sec>\n                    <jats:title>Learning points:<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1530\/edm-17-0176","type":"journal-article","created":{"date-parts":[[2018,4,6]],"date-time":"2018-04-06T05:46:59Z","timestamp":1522993619000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-2","source":"Crossref","is-referenced-by-count":5,"title":["Unusual presentation of pheochromocytoma: thirteen years of anxiety requiring psychiatric treatment"],"prefix":"10.1530","volume":"2018","author":[{"given":"Catherine","family":"Alguire","sequence":"first","affiliation":[{"name":"Division of Endocrinology 1","department":["Department of Medicine and Research Center (CRCHUM), Centre hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al, Montreal, Qu\u00e9bec, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Chbat","sequence":"additional","affiliation":[{"name":"Division of Endocrinology 1","department":["Department of Medicine and Research Center (CRCHUM), Centre hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al, Montreal, Qu\u00e9bec, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Forest","sequence":"additional","affiliation":[{"name":"Department of Psychiatry 2","department":["Centre hospitalier Pierre-Le Gardeur, Terrebonne, Qu\u00e9bec, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariane","family":"Godbout","sequence":"additional","affiliation":[{"name":"Division of Endocrinology 1","department":["Department of Medicine and Research Center (CRCHUM), Centre hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al, Montreal, Qu\u00e9bec, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Bourdeau","sequence":"additional","affiliation":[{"name":"Division of Endocrinology 1","department":["Department of Medicine and Research Center (CRCHUM), Centre hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al, Montreal, Qu\u00e9bec, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","published-online":{"date-parts":[[2018,4,6]]},"reference":[{"key":"2026070712324489200_bib1","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1210\/jc.2014-1498","article-title":"Pheochromocytoma and paraganglioma: an endocrine society clinical practice guideline","volume":"99","author":"Lenders","year":"2014","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"2026070712324489200_bib2","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1055\/s-0031-1299707","article-title":"Metastatic pheochromocytoma and paraganglioma: focus on therapeutics","volume":"44","author":"Plouin","year":"2012","journal-title":"Hormone and Metabolic Research"},{"key":"2026070712324489200_bib3","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1016\/S0140-6736(10)61542-5","article-title":"Hidden harm","volume":"377","author":"Suzuki","year":"2011","journal-title":"Lancet"},{"key":"2026070712324489200_bib4","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.jamcollsurg.2009.09.022","article-title":"Clinical spectrum of pheochromocytoma","volume":"209","author":"Guerrero","year":"2009","journal-title":"Journal of the American College of Surgeons"},{"key":"2026070712324489200_bib5","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1007\/s12020-011-9545-3","article-title":"Pheochromocytomas and paragangliomas: assessment of malignant potential","volume":"40","author":"Korevaar","year":"2011","journal-title":"Endocrine"},{"key":"2026070712324489200_bib6","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1196\/annals.1410.081","article-title":"Pheochromocytoma: an endocrine stress mimicking disorder","volume":"1148","author":"Kantorovich","year":"2008","journal-title":"Annals of the New York Academy of Sciences"},{"key":"2026070712324489200_bib7","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/BF03343961","article-title":"Unusual clinical manifestation of pheochromocytoma in a MEN2A patient","volume":"25","author":"Guerrieri","year":"2002","journal-title":"Journal of Endocrinological Investigation"}],"container-title":["Endocrinology, Diabetes &amp; 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