{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:16:58Z","timestamp":1784557018437,"version":"3.55.0"},"reference-count":20,"publisher":"Bioscientifica","license":[{"start":{"date-parts":[[2018,6,6]],"date-time":"2018-06-06T00:00:00Z","timestamp":1528243200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/deed.en_GB"}],"content-domain":{"domain":["edm.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,6,6]]},"abstract":"Summary<\/jats:title>\n \n Two pediatric patients with different causes of hyperparathyroidism are reported. First patient is a 13-year-old male with severe hypercalcemia due to left upper parathyroid gland adenoma. After successful surgery, calcium and phosphate levels normalized, but parathormone levels remained elevated. Further studies revealed a second adenoma in the right gland. The second patient is a 13-year-old female with uncommon hypercalcemia symptoms. Presence of pathogenic calcium-sensing receptor gene (\n CASR<\/jats:italic>\n ) mutation was found, resulting in diagnosis of symptomatic familial hypocalciuric hypercalcemia. Cinacalcet, a calcium-sensing agent that increases the sensitivity of the CASR, was used in both patients with successful results.\n <\/jats:p>\n \n Learning points:<\/jats:title>\n \n \n Hyperparathyroidism is a rare condition in pediatric patients. If not treated, it can cause serious morbidity.<\/jats:p>\n <\/jats:list-item>\n \n \n Genetic tests searching for\n CASR<\/jats:italic>\n or\n MEN1<\/jats:italic>\n gene mutations in pediatric patients with primary hyperparathyroidism should be performed.\n <\/jats:p>\n <\/jats:list-item>\n \n Cinacalcet has been effective for treating different causes of hyperparathyroidism in our two pediatric patients.<\/jats:p>\n <\/jats:list-item>\n \n Treatment has been well tolerated and no side effects have been detected.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:sec>","DOI":"10.1530\/edm-18-0009","type":"journal-article","created":{"date-parts":[[2018,6,6]],"date-time":"2018-06-06T10:16:05Z","timestamp":1528280165000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-2","source":"Crossref","is-referenced-by-count":3,"title":["Successful use of cinacalcet to treat parathyroid-related hypercalcemia in two pediatric patients"],"prefix":"10.1530","volume":"2018","author":[{"given":"E","family":"Mogas","sequence":"first","affiliation":[{"name":"1Department of Pediatric Endocrinology, Children\u2019s University Hospital Vall Hebron, Barcelona, Spain"},{"name":"2Autonomous University of Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Campos-Martorell","sequence":"additional","affiliation":[{"name":"1Department of Pediatric Endocrinology, Children\u2019s University Hospital Vall Hebron, Barcelona, Spain"},{"name":"2Autonomous University of Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Clemente","sequence":"additional","affiliation":[{"name":"1Department of Pediatric Endocrinology, Children\u2019s University Hospital Vall Hebron, Barcelona, Spain"},{"name":"2Autonomous University of Barcelona, Barcelona, Spain"},{"name":"3Centre for Biomedical Research Network on Rare Diseases (CIBERER), Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Casta\u00f1o","sequence":"additional","affiliation":[{"name":"3Centre for Biomedical Research Network on Rare Diseases (CIBERER), Madrid, Spain"},{"name":"4Endocrinology and Diabetes Research Group, BioCruces Health Research Institute, UPV-EHU, CIBERDEM, Cruces University Hospital, Barakaldo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Moreno-Gald\u00f3","sequence":"additional","affiliation":[{"name":"2Autonomous University of Barcelona, Barcelona, Spain"},{"name":"3Centre for Biomedical Research Network on Rare Diseases (CIBERER), Madrid, Spain"},{"name":"5Department of Pediatrics, Children\u2019s University Hospital Vall Hebron, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Yeste","sequence":"additional","affiliation":[{"name":"1Department of Pediatric Endocrinology, Children\u2019s University Hospital Vall Hebron, Barcelona, Spain"},{"name":"2Autonomous University of Barcelona, Barcelona, Spain"},{"name":"3Centre for Biomedical Research Network on Rare Diseases (CIBERER), Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Carrascosa","sequence":"additional","affiliation":[{"name":"1Department of Pediatric Endocrinology, Children\u2019s University Hospital Vall Hebron, Barcelona, Spain"},{"name":"2Autonomous University of Barcelona, Barcelona, Spain"},{"name":"3Centre for Biomedical Research Network on Rare Diseases (CIBERER), Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"ref101","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1124\/jpet.103.057273","article-title":"Pharmacodynamics of the type II calcimimetic compound cinacalcet HCl","volume":"308","year":"2004","journal-title":"Journal of Pharmacology and Experimental 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