{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T23:17:52Z","timestamp":1784848672556,"version":"3.55.0"},"reference-count":20,"publisher":"Bioscientifica","license":[{"start":{"date-parts":[[2018,7,26]],"date-time":"2018-07-26T00:00:00Z","timestamp":1532563200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/deed.en_GB"}],"content-domain":{"domain":["edm.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,7,26]]},"abstract":"Summary<\/jats:title>\n Laugier\u2013Hunziker syndrome (LHS) is a rare, benign and acquired disorder characterized by hyperpigmentation of the oral cavity and lips along with longitudinal melanonychia. No underlying systemic abnormalities or malignant predisposition is associated with it. In everyday clinical practice, an endocrinologist encounters certain endocrine conditions (e.g. Addison\u2019s disease, McCune\u2013Albright syndrome) that present with, inter alia, mucocutaneous hyperpigmentation. Even though LHS is easily distinguished from endocrine entities mentioned earlier, diagnostic evaluation usually requires skilled and thorough practitioner. Since it is the diagnosis of exclusion, a number of systemic conditions must be ruled out prior to making the final diagnosis. However, its major differential diagnosis is primarily Peutz-Jeghers syndrome, which carries an increased risk of cancer. Here, we report a case of a young woman who was referred to the endocrinologist for diagnostic evaluation of dark-colored lesions of the oral cavity and nails. All performed laboratory tests were within reference range. Endoscopic gastrointestinal evaluation did not reveal neoplastic formations. Owing to an adult-onset, asymptomatic clinical course and negative diagnostic findings, we made a final diagnosis. In this case, target diagnostic evaluation notably reduced the need for additional expensive and invasive procedures and treatments.<\/jats:p>\n \n Learning points:<\/jats:title>\n \n \n Laugier\u2013Hunziker syndrome is a rare, acquired cause of asymptomatic, benign mucocutaneous hyperpigmentation.<\/jats:p>\n <\/jats:list-item>\n \n Prior to making a final diagnosis, certain medical entities with overlapping clinical features must be excluded.<\/jats:p>\n <\/jats:list-item>\n \n Endocrine conditions that usually present with the hyperpigmentation of the skin and mucous membranes (e.g. Addison\u2019s disease, McCune\u2013Albright syndrome) can be easily ruled out based on clinical and laboratory findings.<\/jats:p>\n <\/jats:list-item>\n \n Its major differential diagnosis, Peutz-Jeghers syndrome is characterized by melanotic macules of the face and mouth, intestinal polyposis and significantly increased risk of different types of cancer, especially gastrointestinal.<\/jats:p>\n <\/jats:list-item>\n \n Anamnesis, physical examination and target diagnostic evaluation reduce the need for additional invasive and expensive procedures and treatment.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:sec>","DOI":"10.1530\/edm-18-0025","type":"journal-article","created":{"date-parts":[[2018,7,27]],"date-time":"2018-07-27T01:12:20Z","timestamp":1532653940000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-2","source":"Crossref","is-referenced-by-count":4,"title":["Laugier\u2013Hunziker syndrome in endocrine clinical practice"],"prefix":"10.1530","volume":"2018","author":[{"given":"Tanja","family":"Mili\u010devi\u0107","sequence":"first","affiliation":[{"name":"1Departments of Endocrinology, Diabetes and Metabolic Diseases"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"\u017daja","sequence":"additional","affiliation":[{"name":"2Departments of Gastroenterology and Hepatology, University Hospital Center Split, University of Split Medical School, Split, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"De\u0161a","family":"Te\u0161anovi\u0107","sequence":"additional","affiliation":[{"name":"3Departments of University of Split Medical School, Split, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maja","family":"Radman","sequence":"additional","affiliation":[{"name":"1Departments of Endocrinology, Diabetes and Metabolic Diseases"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"ref121","first-page":"751","article-title":"Do you know this syndrome?","volume":"85","year":"2010","journal-title":"Anais Brasileiros de Dermatologia"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"253","DOI":"10.2165\/00128071-200102040-00006","article-title":"Drug-induced skin pigmentation. 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