{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T05:21:04Z","timestamp":1784092864897,"version":"3.55.0"},"reference-count":13,"publisher":"Bioscientifica","license":[{"start":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T00:00:00Z","timestamp":1771200000000},"content-version":"vor","delay-in-days":2968,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/deed.en_GB"}],"content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,1,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>IgG4-related hypophysitis is an important diagnostic consideration in patients with a pituitary mass or pituitary dysfunction and can initially present with headaches, visual field deficits and\/or endocrine dysfunction. Isolated IgG4-related pituitary disease is rare, with most cases of IgG4-related disease involving additional organ systems. We report the case of a teenage female patient with isolated IgG4-related hypophysitis, diagnosed after initially presenting with headaches. Our patient had no presenting endocrinologic abnormalities. She was treated with surgical resection, prednisolone and rituximab with no further progression of disease and sustained normal endocrine function. This case, the youngest described patient with isolated IgG4-related hypophysitis and uniquely lacking endocrinologic abnormalities, adds to the limited reports of isolated pituitary disease. The use of rituximab for isolated pituitary disease has never been described. While IgG4-related hypophysitis has been increasingly recognized, substantial evidence concerning the appropriate treatment and follow-up of these patients is largely lacking.<\/jats:p>\n                  <jats:sec>\n                    <jats:title>Learning points:<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1530\/edm-18-0135","type":"journal-article","created":{"date-parts":[[2019,1,2]],"date-time":"2019-01-02T06:16:50Z","timestamp":1546409810000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-2","source":"Crossref","is-referenced-by-count":12,"title":["Rituximab treatment for isolated IgG4-related hypophysitis in a teenage female"],"prefix":"10.1530","volume":"2018","author":[{"given":"Danielle R","family":"Bullock","sequence":"first","affiliation":[{"name":"Division of Rheumatology 1","department":["Department of Pediatrics"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley S","family":"Miller","sequence":"additional","affiliation":[{"name":"Division of Endocrinology 2","department":["Department of Pediatrics"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H Brent","family":"Clark","sequence":"additional","affiliation":[{"name":"Division of Neuropathology 3","department":["Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia M","family":"Hobday","sequence":"additional","affiliation":[{"name":"Division of Rheumatology 1","department":["Department of Pediatrics"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","published-online":{"date-parts":[[2018,12,28]]},"reference":[{"key":"2026070712345858900_bib1","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1056\/NEJMra1104650","article-title":"IgG4-related disease","volume":"366","author":"Stone","year":"2012","journal-title":"New England 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