{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:17:02Z","timestamp":1784557022932,"version":"3.55.0"},"reference-count":0,"publisher":"Bioscientifica","license":[{"start":{"date-parts":[[2019,9,12]],"date-time":"2019-09-12T00:00:00Z","timestamp":1568246400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["edm.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,9,12]]},"abstract":"<jats:sec>\n                    <jats:title>Summary<\/jats:title>\n                    <jats:p>\n                      We report our experience on managing a case of florid Cushing\u2019s disease with Methicillin-resistant\n                      <jats:italic>Staphylococcus aureus<\/jats:italic>\n                      (MRSA) sepsis using intravenous etomidate in the intensive care unit of a UK district general hospital.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Learning points:<\/jats:title>\n                    <jats:list list-type=\"bullet\">\n                      <jats:list-item>\n                        <jats:p>Severe Cushing\u2019s syndrome is associated with high morbidity and mortality.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>Etomidate is a safe and effective medical therapy to rapidly lower cortisol levels even in the context of severe sepsis and immunosuppression.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>Etomidate should ideally be administered in an intensive care unit but is still feasible in a district general hospital.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>During treatment with etomidate, accumulation of serum 11\u03b2-deoxycortisol (11DOC) levels can cross-react with laboratory cortisol measurement leading to falsely elevated serum cortisol levels. For this reason, serum cortisol measurement using a mass spectrometry assay should ideally be used to guide etomidate prescription.<\/jats:p>\n                      <\/jats:list-item>\n                    <\/jats:list>\n                  <\/jats:sec>","DOI":"10.1530\/edm-19-0044","type":"journal-article","created":{"date-parts":[[2019,9,16]],"date-time":"2019-09-16T06:05:50Z","timestamp":1568613950000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-2","source":"Crossref","is-referenced-by-count":2,"title":["Etomidate in the management of severe Cushing\u2019s disease and MRSA bacteraemia in a district general hospital in the United Kingdom"],"prefix":"10.1530","volume":"2019","author":[{"given":"Stephanie Wei Ping","family":"Wong","sequence":"first","affiliation":[{"name":"1Department of Diabetes and EndocrinologySt Helens and Knowsley Teaching Hospitals NHS Trust, Prescot, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yew Wen","family":"Yap","sequence":"additional","affiliation":[{"name":"1Department of Diabetes and EndocrinologySt Helens and Knowsley Teaching Hospitals NHS Trust, Prescot, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ram Prakash","family":"Narayanan","sequence":"additional","affiliation":[{"name":"1Department of Diabetes and EndocrinologySt Helens and Knowsley Teaching Hospitals NHS Trust, Prescot, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Al-Jubouri","sequence":"additional","affiliation":[{"name":"2Department of BiochemistrySt Helens and Knowsley Teaching Hospitals NHS Trust, Prescot, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Grossman","sequence":"additional","affiliation":[{"name":"3Centre for EndocrinologyWilliam Harvey Research Institute, Barts and London School of Medicine and Dentistry, Queen Mary University of London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Daousi","sequence":"additional","affiliation":[{"name":"4Department of Diabetes and EndocrinologyAintree University Hospital NHS Foundation Trust, Liverpool, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yahya","family":"Mahgoub","sequence":"additional","affiliation":[{"name":"1Department of Diabetes and EndocrinologySt Helens and Knowsley Teaching Hospitals NHS Trust, Prescot, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","container-title":["Endocrinology, Diabetes &amp; Metabolism Case Reports"],"original-title":[],"link":[{"URL":"https:\/\/edm.bioscientifica.com\/view\/journals\/edm\/2019\/1\/EDM19-0044.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/edm.bioscientifica.com\/downloadpdf\/journals\/edm\/2019\/1\/EDM19-0044.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:47:06Z","timestamp":1784555226000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.bioscientifica.com\/edm\/article\/35395"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,12]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1530\/edm-19-0044","relation":{},"ISSN":["2052-0573"],"issn-type":[{"value":"2052-0573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,12]]}}}