{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:27:36Z","timestamp":1787318856898,"version":"build-2736575974"},"reference-count":0,"publisher":"Bioscientifica","content-domain":{"domain":["edm.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,5,29]]},"abstract":"<jats:sec>\n                    <jats:title>Summary<\/jats:title>\n                    <jats:p>Lingual thyroid (LT) gland is the most common type of ectopic thyroid tissue, but it is an extremely rare presentation. We present a case of a 41-year-old Hispanic female patient complaining of dysphonia and dysphagia. As part of the evaluation, fiber optic flexible indirect laryngoscopy (FIL) was performed which revealed a mass at the base of the tongue. The morphological examination was highly suspicious for ectopic thyroid tissue and the diagnosis was confirmed with neck ultrasound and thyroid scintigraphy. Although the patient presented subclinical hypothyroidism, levothyroxine therapy was initiated with a favorable response which included resolution of symptoms and mass size reduction. Our case portrays how thyroid hormone replacement therapy (THRT) may lead to a reduction in the size of the ectopic tissue and improvement of symptoms, thus avoiding the need for surgical intervention which could result in profound hypothyroidism severely affecting the patients\u2019 quality of life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Learning points:<\/jats:title>\n                    <jats:list list-type=\"bullet\">\n                      <jats:list-item>\n                        <jats:p>Benign LT and malignant LT are indistinguishable clinically and radiographically for which histopathology is recommended.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>THRT, radioactive iodine 131 (RAI) therapy, and surgical excision are potential management options for LT.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>THRT may lead to size reduction of the ectopic tissue and resolution of symptoms avoiding surgical intervention.<\/jats:p>\n                      <\/jats:list-item>\n                    <\/jats:list>\n                  <\/jats:sec>","DOI":"10.1530\/edm-20-0026","type":"journal-article","created":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T03:15:43Z","timestamp":1590981343000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-2","source":"Crossref","is-referenced-by-count":9,"title":["Lingual thyroid gland: it\u2019s time for awareness"],"prefix":"10.1530","volume":"2020","author":[{"given":"Nicol\u00e1s","family":"Cruz-Dard\u00edz","sequence":"first","affiliation":[{"name":"1Endocrinology Department, San Juan City Hospital, San Juan, Puerto Rico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadyeschka","family":"Rivera-Santana","sequence":"additional","affiliation":[{"name":"1Endocrinology Department, San Juan City Hospital, San Juan, Puerto Rico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Torres-Torres","sequence":"additional","affiliation":[{"name":"2Internal Medicine Department, San Juan City Hospital, San Juan, Puerto Rico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9ctor","family":"Cintr\u00f3n-Col\u00f3n","sequence":"additional","affiliation":[{"name":"2Internal Medicine Department, San Juan City Hospital, San Juan, Puerto Rico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shayanne","family":"Lajud","sequence":"additional","affiliation":[{"name":"3Otolaryngology Head and Neck Surgery, University of Puerto Rico, Medical Science Campus, San Juan, Puerto Rico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernesto","family":"Sol\u00e1-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"1Endocrinology Department, San Juan City Hospital, San Juan, Puerto Rico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Mangual-Garc\u00eda","sequence":"additional","affiliation":[{"name":"1Endocrinology Department, San Juan City Hospital, San Juan, Puerto Rico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Gonz\u00e1lez-B\u00f3ssolo","sequence":"additional","affiliation":[{"name":"1Endocrinology Department, San Juan City Hospital, San Juan, Puerto Rico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","container-title":["Endocrinology, Diabetes &amp; Metabolism Case Reports"],"original-title":[],"link":[{"URL":"https:\/\/edm.bioscientifica.com\/view\/journals\/edm\/2020\/1\/EDM20-0026.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/edm.bioscientifica.com\/downloadpdf\/journals\/edm\/2020\/1\/EDM20-0026.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:47:18Z","timestamp":1784555238000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.bioscientifica.com\/edm\/article\/3289"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,29]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1530\/edm-20-0026","relation":{},"ISSN":["2052-0573"],"issn-type":[{"value":"2052-0573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,29]]}}}