{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T14:07:28Z","timestamp":1785161248545,"version":"3.55.0"},"reference-count":0,"publisher":"Bioscientifica","content-domain":{"domain":["edm.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,6,16]]},"abstract":"\n Summary<\/jats:title>\n Dupilumab an inhibitor of the interleukin (IL)-4R-alpha subunit is used for the treatment of allergic diseases. The patient was a 49-year-old man who received dupilumab for the treatment of severe atopic dermatitis. He presented hyperthyroidism with elevated thyroglobulin and anti-thyroid antibody negativity at 4 months after the initiation of therapy. On scintigraphy, the thyroid radioiodine uptake was low. Ultrasonography showed a diffuse hypoechoic area in the thyroid gland. A pathological study revealed lymphocytic infiltration. The administration of dupilumab was continued because of his atopic dermatitis that showed an excellent response. The patient`s hyperthyroidism changed to hypothyroidism 3 weeks later. Six months later his thyroid function normalized without any treatment. We herein describe the case of a patient with atopic dermatitis who developed painless thyroiditis under treatment with dupilumab. To the best of our knowledge, this is the first report of this event in the literature.<\/jats:p>\n <\/jats:sec>\n \n Learning points:<\/jats:title>\n \n \n Dupilumab, a fully human monoclonal antibody that blocks interleukin-4 and interleukin-13, has been shown to be effective in the treatment atopic dermatitis and asthma with eosinophilia.<\/jats:p>\n <\/jats:list-item>\n \n Painless thyroiditis is characterized by transient hyperthyroidism and hypothyroidism and recovery without anti-thyroid treatment.<\/jats:p>\n <\/jats:list-item>\n \n This is the first report of painless thyroiditis as an adverse effect of dupilumab, although conjunctivitis and nasopharyngitis are the main adverse effects of dupilumab.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:sec>","DOI":"10.1530\/edm-20-0030","type":"journal-article","created":{"date-parts":[[2020,6,17]],"date-time":"2020-06-17T04:06:29Z","timestamp":1592366789000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-2","source":"Crossref","is-referenced-by-count":5,"title":["Painless thyroiditis in a dupilumab-treated patient"],"prefix":"10.1530","volume":"2020","author":[{"given":"Daramjav","family":"Narantsatsral","sequence":"first","affiliation":[{"name":"1Division of Endocrinology and Metabolism, Department of Internal Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takagi","family":"Junko","sequence":"additional","affiliation":[{"name":"1Division of Endocrinology and Metabolism, Department of Internal Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iwayama","family":"Hideyuki","sequence":"additional","affiliation":[{"name":"2Department of Pediatrics, Aichi Medical University School of Medicine, Nagakute, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inukai","family":"Daisuke","sequence":"additional","affiliation":[{"name":"3Department of Otolaryngology, Aichi Medical University School of Medicine, Nagakute, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takama","family":"Hiroyuki","sequence":"additional","affiliation":[{"name":"4Department of Dermatology, Aichi Medical University School of Medicine, Nagakute, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nomura","family":"Yuka","sequence":"additional","affiliation":[{"name":"1Division of Endocrinology and Metabolism, Department of Internal Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirase","family":"Syo","sequence":"additional","affiliation":[{"name":"1Division of Endocrinology and Metabolism, Department of Internal Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morita","family":"Hiroyuki","sequence":"additional","affiliation":[{"name":"1Division of Endocrinology and Metabolism, Department of Internal Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Otake","family":"Kazuo","sequence":"additional","affiliation":[{"name":"1Division of Endocrinology and Metabolism, Department of Internal Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ogawa","family":"Tetsuya","sequence":"additional","affiliation":[{"name":"3Department of Otolaryngology, Aichi Medical University School of Medicine, Nagakute, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takami","family":"Akiyoshi","sequence":"additional","affiliation":[{"name":"5Department of Hematology, Aichi Medical University School of Medicine, Nagakute, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","container-title":["Endocrinology, Diabetes & Metabolism Case Reports"],"original-title":[],"link":[{"URL":"https:\/\/edm.bioscientifica.com\/view\/journals\/edm\/2020\/1\/EDM20-0030.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/edm.bioscientifica.com\/downloadpdf\/journals\/edm\/2020\/1\/EDM20-0030.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:47:19Z","timestamp":1784555239000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.bioscientifica.com\/edm\/article\/3353"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,16]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1530\/edm-20-0030","relation":{},"ISSN":["2052-0573"],"issn-type":[{"value":"2052-0573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,16]]}}}