{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:17:07Z","timestamp":1784557027908,"version":"3.55.0"},"reference-count":0,"publisher":"Bioscientifica","license":[{"start":{"date-parts":[[2021,1,27]],"date-time":"2021-01-27T00:00:00Z","timestamp":1611705600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["edm.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,1,27]]},"abstract":"<jats:sec>\n                    <jats:title>Summary<\/jats:title>\n                    <jats:p>\n                      Comorbidities are a risk factor for patients with COVID-19 and the mechanisms of disease remain unclear. The aim of this paper is to present a case report of an COVID-19 patient with severe hypocalcaemia. This is a report of an 81-year-old female, suffered from myalgia and fatigue for more than 3\u20134 weeks. Fever and cough appear 2 days before she presented to the emergency room. On physical examination, she was febrile with a temperature of 38.8\u00b0C, accompanied by cough, sore throat, headache, fatigue, and muscle ache. Her past medical history was remarkable with no chronic disease. She had lymphopenia. Laboratory test revealed moderate liver dysfunction, hypoalbuminemia, and severe hypocalcaemia (serum corrected calcium level: 5.7\u2009 mg\/dL). Parathyroid hormone (PTH) was 107.9 pg\/mL (range: 15\u201365) and 25(OH)2D levels was 4.5 ng\/mL (range: 25\u201380). Chest CT scan detected peripheral ground-glass opacity. Throat swab for coronavirus by RT-PCR\n                      <jats:italic\/>\n                      assay tested positive for the virus. She was treated with lopinavir\/ritonavir, third generation cephalosporin, anticoagulant, daily high-dose calcium acetate, vitamin D\n                      <jats:sub>3<\/jats:sub>\n                      , fresh frozen plasma and oxygen therapy. She was discharged after two negative throat swab tests for coronavirus by conventional RT-PCR.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Learning points:<\/jats:title>\n                    <jats:list list-type=\"bullet\">\n                      <jats:list-item>\n                        <jats:p>Comorbidities are a risk factor for patients with COVID-19.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>Laboratory findings are unspecific in COVID-19 patients; laboratory abnormalities include lymphopenia, elevated of LDH, CPK and the inflammatory markers, such as C reactive protein, ferritinemia and the erythrocyte sedimentation rate.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>In addition to inflammatory markers, in COVID-19 patients it is crucial to check the level of vitamin D and calcium.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>There may be a correlation between vitamin D deficiency and the severity of COVID-19 disease.<\/jats:p>\n                      <\/jats:list-item>\n                    <\/jats:list>\n                  <\/jats:sec>","DOI":"10.1530\/edm-20-0097","type":"journal-article","created":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T06:04:10Z","timestamp":1612159450000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-2","source":"Crossref","is-referenced-by-count":3,"title":["Severe hypocalcaemia in a COVID-19 female patient"],"prefix":"10.1530","volume":"2021","author":[{"given":"Edmond","family":"Puca","sequence":"first","affiliation":[{"name":"1Service of Infection Diseases, University Hospital Center, Tirane, Albania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Entela","family":"Puca","sequence":"additional","affiliation":[{"name":"2Service of Endocrinology, Amerikan Hospital, Tirane, Albania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pellumb","family":"Pipero","sequence":"additional","affiliation":[{"name":"1Service of Infection Diseases, University Hospital Center, Tirane, Albania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holta","family":"Kraja","sequence":"additional","affiliation":[{"name":"3Service of Anaesthesia and Reanimation, University Hospital Center, Tirane, Albania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Najada","family":"Como","sequence":"additional","affiliation":[{"name":"1Service of Infection Diseases, University Hospital Center, Tirane, Albania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","container-title":["Endocrinology, Diabetes &amp; Metabolism Case Reports"],"original-title":[],"link":[{"URL":"https:\/\/edm.bioscientifica.com\/view\/journals\/edm\/2021\/1\/EDM20-0097.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/edm.bioscientifica.com\/downloadpdf\/journals\/edm\/2021\/1\/EDM20-0097.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:47:25Z","timestamp":1784555245000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.bioscientifica.com\/edm\/article\/3320"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,27]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1530\/edm-20-0097","relation":{},"ISSN":["2052-0573"],"issn-type":[{"value":"2052-0573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,27]]}}}