{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T13:34:22Z","timestamp":1787751262941,"version":"build-2784847793"},"reference-count":0,"publisher":"Bioscientifica","content-domain":{"domain":["edm.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,10,6]]},"abstract":"<jats:sec>\n                    <jats:title>Summary<\/jats:title>\n                    <jats:p>Despite improvements in localisation techniques and surgical advances, some patients with insulinoma will not be cured by surgery or may not be suitable for surgery. Medical management with diazoxide is an option for such cases. This case report details 27 years of successful management of insulinoma using diazoxide. It has been effective and safe, with only minor adverse effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Learning points:<\/jats:title>\n                    <jats:list list-type=\"bullet\">\n                      <jats:list-item>\n                        <jats:p>Long term diazoxide use can be a safe, effective option for insulinoma when it cannot be localised or removed surgically.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>Common adverse effects include peripheral oedema, hyperuricaemia, and hirsutism.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>\n                          <jats:sup>68<\/jats:sup>\n                          Ga-NOTA-exendin-4 PET\/CT scan should be considered for insulinoma localisation when other modalities have been unhelpful.\n                        <\/jats:p>\n                      <\/jats:list-item>\n                    <\/jats:list>\n                  <\/jats:sec>","DOI":"10.1530\/edm-20-0132","type":"journal-article","created":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T05:33:42Z","timestamp":1602135222000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-2","source":"Crossref","is-referenced-by-count":8,"title":["Successful medical management of insulinoma with diazoxide for 27 years"],"prefix":"10.1530","volume":"2020","author":[{"given":"Annabelle M","family":"Warren","sequence":"first","affiliation":[{"name":"1Department of Endocrinology and Diabetes, Alfred Health, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duncan J","family":"Topliss","sequence":"additional","affiliation":[{"name":"1Department of Endocrinology and Diabetes, Alfred Health, Melbourne, Victoria, Australia"},{"name":"2Monash University, Central Clinical School, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter Shane","family":"Hamblin","sequence":"additional","affiliation":[{"name":"1Department of Endocrinology and Diabetes, Alfred Health, Melbourne, Victoria, Australia"},{"name":"2Monash University, Central Clinical School, Melbourne, Victoria, Australia"},{"name":"3Department of Endocrinology and Diabetes, Western Health, Melbourne, Victoria, Australia"},{"name":"4Department of Medicine, Western Clinical School, The University of Melbourne, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","container-title":["Endocrinology, Diabetes &amp; Metabolism Case Reports"],"original-title":[],"link":[{"URL":"https:\/\/edm.bioscientifica.com\/view\/journals\/edm\/2020\/1\/EDM20-0132.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/edm.bioscientifica.com\/downloadpdf\/journals\/edm\/2020\/1\/EDM20-0132.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:47:28Z","timestamp":1784555248000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.bioscientifica.com\/edm\/article\/3557"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,6]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1530\/edm-20-0132","relation":{},"ISSN":["2052-0573"],"issn-type":[{"value":"2052-0573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,6]]}}}