{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:17:53Z","timestamp":1784557073240,"version":"3.55.0"},"reference-count":5,"publisher":"Bioscientifica","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["edm.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,3,1]]},"abstract":"<jats:sec>\n                    <jats:title>Summary<\/jats:title>\n                    <jats:p>Central diabetes insipidus (DI) is characterized by decreased release of antidiuretic hormone, resulting in a variable degree of polyuria. The etiologies are variable, with the vast majority of cases either being idiopathic or resulting from primary or secondary tumors. Such tumors include craniopharyngioma, Langerhans cell histiocytosis, or a variety of inflammatory, vascular, or granulomatous diseases. It is exceptionally rare for pituitary adenomas to present with DI. We describe a young patient who first presented with symptoms consistent with DI. He was tested for DI and found to have panhypopituitarism due to a metastatic pineal germ cell tumor causing thickening of his pituitary stalk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Learning points<\/jats:title>\n                    <jats:list list-type=\"bullet\">\n                      <jats:list-item>\n                        <jats:p>New onset central diabetes insipidus requires dedicated pituitary MRI for determination of etiology.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>Germ cell tumors in the pineal and suprasellar regions most commonly cause central diabetes insipidus.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>Determining the etiology of new-onset central diabetes insipidus can radically affect treatment.<\/jats:p>\n                      <\/jats:list-item>\n                    <\/jats:list>\n                  <\/jats:sec>","DOI":"10.1530\/edm-21-0021","type":"journal-article","created":{"date-parts":[[2022,3,10]],"date-time":"2022-03-10T05:42:56Z","timestamp":1646890976000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-2","source":"Crossref","is-referenced-by-count":1,"title":["Panhypopituitarism in a patient with a hypothalamic and pineal germ cell tumor"],"prefix":"10.1530","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0808-6465","authenticated-orcid":true,"given":"Adam","family":"Puchalski","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Lahey Hospital and Medical Center, Burlington, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Elias","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Lahey Hospital and Medical Center, Burlington, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"bib1","series-title":"Proceedings","first-page":"43","article-title":"Intracranial germinoma","volume":"28","author":"Reddy","year":"2015","unstructured":"Reddy MPSaad AFDoughty KEArmstrong DMelguizo-Gavilanes ICheek BSOpatowsky MJ. Intracranial germinoma. Proceedings20152843\u201345. (https:\/\/doi.org\/10.1080\/08998280.2015.11929183)"},{"key":"bib2","series-title":"Endocrine Practice","doi-asserted-by":"publisher","first-page":"1458","DOI":"10.4158\/EP-2020-0192","article-title":"Pituitary dysfunction in patients with intracranial germ cell tumors treated with radiotherapy","volume":"26","author":"Xiang","year":"2020","unstructured":"Xiang BZhu XHe MWu WPang HZhang ZYang YLi YWang YWang YPituitary dysfunction in patients with intracranial germ cell tumors treated with radiotherapy. Endocrine Practice2020261458\u20131468. (https:\/\/doi.org\/10.4158\/EP-2020-0192)10.4158\/EP-2020-0192"},{"key":"bib3","series-title":"Acta Oncologica","doi-asserted-by":"publisher","first-page":"3","DOI":"10.3109\/0284186X.2011.586000","article-title":"Intracranial germ cell tumours. A review with special reference to endocrine manifestations","volume":"51","author":"Jorsal","year":"2012","unstructured":"Jorsal TR\u00f8rth M. Intracranial germ cell tumours. A review with special reference to endocrine manifestations. Acta Oncologica2012513\u20139. (https:\/\/doi.org\/10.3109\/0284186X.2011.586000)10.3109\/0284186X.2011.586000"},{"key":"bib4","series-title":"Acta Endocrinologica","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1530\/acta.0.1200337","article-title":"Endocrine disturbances in suprasellar germinomas","volume":"120","author":"Buchfelder","year":"1989","unstructured":"Buchfelder MFahlbusch RWalther MMann K. Endocrine disturbances in suprasellar germinomas. Acta Endocrinologica1989120337\u2013342. (https:\/\/doi.org\/10.1530\/acta.0.1200337)10.1530\/acta.0.1200337"},{"key":"bib5","series-title":"Endocrine Journal","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1507\/endocrj.41.287","article-title":"Effects of therapy on anterior pituitary functions in patients with primary intracranial germ cell tumor","volume":"41","author":"Kumanogoh","year":"1994","unstructured":"Kumanogoh AKasayama SKouhara HKoga MArita NHayakawa TKishimoto TSato B. Effects of therapy on anterior pituitary functions in patients with primary intracranial germ cell tumor. Endocrine Journal199441287\u2013292. (https:\/\/doi.org\/10.1507\/endocrj.41.287)10.1507\/endocrj.41.287"}],"container-title":["Endocrinology, Diabetes &amp; Metabolism Case Reports"],"original-title":[],"link":[{"URL":"https:\/\/edm.bioscientifica.com\/view\/journals\/edm\/2022\/1\/EDM21-0021.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/edm.bioscientifica.com\/downloadpdf\/journals\/edm\/2022\/1\/EDM21-0021.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/edm.bioscientifica.com\/downloadpdf\/journals\/edm\/2022\/1\/EDM21-0021.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:47:37Z","timestamp":1784555257000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.bioscientifica.com\/edm\/article\/3378"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,1]]},"references-count":5,"URL":"https:\/\/doi.org\/10.1530\/edm-21-0021","relation":{},"ISSN":["2052-0573"],"issn-type":[{"value":"2052-0573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,1]]}}}