{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T20:42:47Z","timestamp":1793392967891,"version":"4.5.0"},"reference-count":10,"publisher":"Bioscientifica","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["edm.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,1,1]]},"abstract":"<jats:sec>\n                    <jats:title>Summary<\/jats:title>\n                    <jats:p>Juxtaglomerular cell tumour (JGCT) is an unusually encountered clinical entity. A 33-year-old man with severe long-standing hypertension and hypokalaemia is described. The patient also suffered from polyuria, polydipsia, nocturia and severe headaches. On admission, laboratory investigation revealed hypokalaemia, kaliuresis, high aldosterone and renin levels, and the abdomen CT identified a mass of 4 cm at the right kidney. Kidney function was normal. Following nephrectomy, the histological investigation revealed the presence of a JGCT. Immunostaining was positive for CD34 as well as for smooth muscle actin and vimentin. Following surgery, a marked control of his hypertension with calcium channel blockers and normalization of the serum potassium, renin or aldosterone levels were reached. According to our findings, JGCT could be included in the differential diagnosis of secondary hypertension as it consists of a curable cause. The association of JGCT with hypertension and hypokalaemia focusing on the clinical presentation, diagnostic evaluation and management is herein discussed and a brief review of the existing literature is provided.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Learning points<\/jats:title>\n                    <jats:list list-type=\"bullet\">\n                      <jats:list-item>\n                        <jats:p>Juxtaglomerular cell tumours (JGCT), despite their rarity, should be included in the differential diagnosis of secondary hypertension as they consist of a curable cause of hypertension.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>JGCT could be presented with resistant hypertension along with hypokalaemia, kaliuresis and metabolic alkalosis. Early recognition and management can help to prevent cardiovascular complications.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>Imaging (enhanced CT scans) may be considered as the primary diagnostic tool for the detection of renal or JGCT.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>For the confirmation of the diagnosis, a histopathologic examination is needed.<\/jats:p>\n                      <\/jats:list-item>\n                    <\/jats:list>\n                  <\/jats:sec>","DOI":"10.1530\/edm-21-0042","type":"journal-article","created":{"date-parts":[[2022,1,13]],"date-time":"2022-01-13T06:35:19Z","timestamp":1642055719000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-2","source":"Crossref","is-referenced-by-count":2,"title":["Juxtaglomerular cell tumour of the kidney: a rare cause of resistant hypertension"],"prefix":"10.1530","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5350-2846","authenticated-orcid":true,"given":"Nikitas S","family":"Skarakis","sequence":"first","affiliation":[{"name":"Unit of Endocrinology and Diabetes Center, \u2018G. Gennimatas\u2019 General Hospital, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Papadimitriou","sequence":"additional","affiliation":[{"name":"Unit of Endocrinology and Diabetes Center, \u2018G. Gennimatas\u2019 General Hospital, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Labrini","family":"Papanastasiou","sequence":"additional","affiliation":[{"name":"Unit of Endocrinology and Diabetes Center, \u2018G. Gennimatas\u2019 General Hospital, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Pappa","sequence":"additional","affiliation":[{"name":"Department of Pathology, \u2018G. Gennimatas\u2019 General Hospital, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasia","family":"Dimitriadi","sequence":"additional","affiliation":[{"name":"Department of Pathology, \u2018G. Gennimatas\u2019 General Hospital, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Glykas","sequence":"additional","affiliation":[{"name":"Department of Urology, General Hospital of Athens \u2018G Gennimatas\u2019, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Ntoumas","sequence":"additional","affiliation":[{"name":"Department of Urology, General Hospital of Athens \u2018G Gennimatas\u2019, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Penelope","family":"Lampropoulou","sequence":"additional","affiliation":[{"name":"Department of Radiology, General Hospital of Athens \u2018G Gennimatas\u2019, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodora","family":"Kounadi","sequence":"additional","affiliation":[{"name":"Unit of Endocrinology and Diabetes Center, \u2018G. Gennimatas\u2019 General Hospital, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"bib1","series-title":"Acta Pathologica Japonica","first-page":"197","article-title":"A hitherto unreported vascular tumor of the kidney: a proposal of \u2018juxtaglomerular cell tumor\u2019","volume":"18","author":"Kihara","year":"1968","unstructured":"Kihara IKitamura SHoshino TSeida HWatanabe T. A hitherto unreported vascular tumor of the kidney: a proposal of \u2018juxtaglomerular cell tumor\u2019. Acta Pathologica Japonica196818197\u2013206. (https:\/\/doi.org\/10.1111\/j.1440-1827.1968.tb00048.x)"},{"key":"bib2","series-title":"Frontiers in Pediatrics","article-title":"Reninoma: an uncommon cause of renin-mediated hypertension","volume":"2","author":"Trnka","year":"2014","unstructured":"Trnka POrellana LWalsh MPool LBorzi P. Reninoma: an uncommon cause of renin-mediated hypertension. Frontiers in Pediatrics20142 89. 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